Eye drop of deproteinized calf blood extractive

A technology of eye drops and calf blood, which is applied in the direction of drug combination, drug delivery, active ingredients of hydroxyl compounds, etc., can solve the problems of unsatisfactory stability and unsuitability for ophthalmic preparations, and achieve easy control of the production process and clear appearance , low irritation effect

Active Publication Date: 2010-07-21
SHENYANG XINGQI PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Although calf blood deproteinized extract injection is currently used clinically in China, the inventors found that this injection with Tween-80 is not suitable as an ophthalmic preparation because of its unsatisfactory stability. used as eye drops

Method used

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  • Eye drop of deproteinized calf blood extractive
  • Eye drop of deproteinized calf blood extractive
  • Eye drop of deproteinized calf blood extractive

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] prescription:

[0028] Calf blood deproteinized extract 200ml

[0029] Phenoxyethanol 5.0g

[0030] Benzalkonium Chloride 0.1g

[0031] Oligochitosan 0.5g

[0032] Appropriate amount of water for injection

[0033]

[0034] Full volume 1000ml

[0035] Preparation Process:

[0036] Weigh the prescribed amount of phenoxyethanol, benzalkonium chloride, and chitosan oligosaccharide under sterile conditions, heat and dissolve with an appropriate amount of water for injection, cool to room temperature, and add calf blood deproteinized extract and water for injection to the full amount. First filter with a 0.45 μm microporous membrane, then filter and sterilize with a 0.22 μm microporous membrane, and fill to obtain eye drops. The molecular weight of chitosan oligosaccharide used in this embodiment is below 5000.

Embodiment 2

[0038] prescription:

[0039] Calf blood deproteinized extract 200ml

[0040] Phenoxyethanol 5.0g

[0041] Ethylparaben 0.1g

[0042] Oligochitosan 0.5g

[0043] Appropriate amount of water for injection

[0044]

[0045] Full volume 1000ml

[0046] Preparation Process:

[0047] Weigh the prescribed amount of phenoxyethanol, ethylparaben, and chitosan oligosaccharide under sterile conditions, heat and dissolve with an appropriate amount of water for injection, cool to room temperature, and add calf blood deproteinized extract and water for injection to the full amount. First filter with a 0.45 μm microporous membrane, then filter and sterilize with a 0.22 μm microporous membrane, and fill to obtain eye drops. The molecular weight of chitosan oligosaccharide used in this embodiment is below 3000.

Embodiment 3

[0049] prescription:

[0050] Calf blood deproteinized extract 200ml

[0051] Chlorobutanol 1.0g

[0052] Benzalkonium Chloride 0.1g

[0053] Oligochitosan 1.0g

[0054] Appropriate amount of water for injection

[0055]

[0056] Full volume 1000ml

[0057] Preparation Process:

[0058] Weigh the prescribed amount of chlorobutanol, benzalkonium chloride, and chitosan oligosaccharide under sterile conditions, heat and dissolve with an appropriate amount of water for injection, cool to room temperature, and add calf blood deproteinized extract and water for injection to the full amount. First filter with a 0.45 μm microporous membrane, then filter and sterilize with a 0.22 μm microporous membrane, and fill to obtain eye drops. The molecular weight of chitosan oligosaccharide used in this embodiment is below 1500.

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Abstract

The invention provides an eye drop, which comprises an effective treatment amount of deproteinized calf blood extractive, chitosan and water. The eye drop of the invention is stable and can be used for curing keratonosus, conjunctival lesion and dry eye syndrome.

Description

Technical field: [0001] The invention relates to an eye drop containing calf blood deproteinized extract. Background technique: [0002] Calf blood deproteinized extract is a biological preparation researched and invented by German scholar Professor Jaeger. It is made from the blood of healthy and vigorously developed calves within six months of birth, and the molecular weight is less than 6000, which is made by membrane filtration technology. Deproteinized blood extract. This deproteinized blood extract contains electrolytes, trace essential elements, nucleic acid derivatives, amino acids, oligosaccharides, low-molecular-weight polypeptides, glycolipids, and intermediate products of lipid metabolism. Calf blood protein-free extract can promote the uptake and utilization of glucose and oxygen by cell mitochondria at the cellular level (independent of insulin), increase ATP synthesis, increase cell energy, and activate various enzyme activities. In the case of low blood oxy...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/14A61K47/16A61P27/02A61K31/722
CPCA61K31/05A61K31/085A61K9/0048A61K35/14A61K47/36A61K31/722A61K31/00A61P27/02A61K2300/00
Inventor 刘继东艾立诚杨宇春
Owner SHENYANG XINGQI PHARM CO LTD
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