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Simple method for preparing hydroxyapatite nanocrystals

A technology of hydroxyapatite and nanocrystals, which is applied in the field of material chemistry, can solve the problems of unfavorable industrial production, reduced product purity, and increased production cost, and achieve the effects of fast reaction, high product purity, and easy operation

Inactive Publication Date: 2010-07-21
HENAN NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the addition of dispersant not only increases the production cost, but also reduces the purity of the product.
Above-mentioned method is all unfavorable for industrialized production

Method used

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  • Simple method for preparing hydroxyapatite nanocrystals
  • Simple method for preparing hydroxyapatite nanocrystals
  • Simple method for preparing hydroxyapatite nanocrystals

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach 1

[0017] (1) Add 0.04mol calcium nitrate to 250ml water and stir quickly to dissolve to obtain Ca 2+ solution;

[0018] (2) will contain 0.027mol PO 4 3- Pour 110mL of ammonia water-potassium dihydrogen phosphate buffer system (pH=7) into the prepared 250ml of calcium nitrate solution, and stir at 200 rpm for 72 hours at 10°C at 1 atmospheric pressure;

[0019] (3) The product was separated by suction filtration and dried. The transmission electron microscope photo of the obtained hydroxyapatite nanocrystals is shown in figure 1 , X-ray diffraction pattern see figure 2 , and the EDS energy spectrum see image 3 .

Embodiment approach 2

[0021] (1) Add 0.045mol calcium nitrate to 250ml water and stir rapidly to dissolve Ca 2+ solution;

[0022] (2) will contain 0.030mol PO 4 3- 110mL ammonia water-ammonium dihydrogen phosphate buffer system (pH=11) was poured into the prepared 250ml calcium nitrate solution, and stirred at 800 rpm for 48 hours at 1 atmosphere pressure and 25°C;

[0023] (3) The product was separated by suction filtration and dried. The transmission electron microscope photo of the obtained hydroxyapatite nanocrystals is shown in figure 1 , X-ray diffraction pattern see figure 2 , and the EDS energy spectrum see image 3 .

Embodiment approach 3

[0025] (1) Add 0.9mol calcium nitrate to 500ml water and stir quickly to dissolve Ca 2+ solution;

[0026] (2) will contain 0.6mol PO 4 3- Pour 1500mL of ammonia water-diammonium hydrogen phosphate buffer system (pH=14) into the prepared 500ml calcium nitrate solution, and stir at 1400 rpm for 24 hours at 40°C under 1 atmosphere pressure;

[0027] (3) The product was separated by suction filtration and dried. The transmission electron microscope photo of the obtained hydroxyapatite nanocrystals is shown in figure 1 , X-ray diffraction pattern see figure 2 , and the EDS energy spectrum see image 3 .

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Abstract

The invention relates to a simple method for preparing hydroxyapatite nanocrystals, comprising the following steps: preparing the hydroxyapatite nanocrystals through one-step reaction of calcium ion solution in a buffer solution system (PH=7-14) containing phosphate anions under one atmospheric pressure and at the temperature of 10-40 DEG C. The preparation method does not need special device nor special reaction condition nor heating nor calcining nor adding organic substrate as dispering agent or stabilizing agent. The method has the characteristics of simple technology, low energy consumption, high yield, environmental protection, and the like, and is applied to large-scale industrial production.

Description

technical field [0001] The invention belongs to the technical field of material chemistry and relates to a simple preparation method of hydroxyapatite nanocrystals. Background technique [0002] Hydroxyapatite is a bioactive material that provides cells with a microenvironment similar to natural bone, which is conducive to the adhesion and proliferation of osteoblasts, and is mainly used for the repair and replacement of biological hard tissues. At present, there are many preparation methods for hydroxyapatite nanocrystals, but most of the preparation methods are carried out under high temperature calcination, microwave, hydrothermal, ultrasonic and other conditions, and the harsh reaction conditions make the production cost relatively high. In addition, there is also a method of adding a dispersant to the reaction system. However, the addition of dispersant not only increases the production cost, but also reduces the purity of the product. Above-mentioned method is all un...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C30B29/14C30B7/14C01B25/32
Inventor 杨林王魁王华杰姚文广仉华王菲菲曹莹
Owner HENAN NORMAL UNIV
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