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Spray for treating radioactive xerostomia and preparation method thereof

A technology of spray and xerostomia, which is applied in the field of spray and its preparation for the treatment of radioactive xerostomia, which can solve the problems of inconvenience and inability for patients to enjoy, and achieve the effect of maintaining oral hygiene and preventing oral infection

Active Publication Date: 2012-06-13
GUILIN NATURAL INGREDIENTS CORP +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

A number of studies have confirmed that artificial saliva can significantly improve the dry mouth symptoms of patients, but the main components of existing artificial saliva are carboxymethylcellulose, polyethylene oxide or animal mucin, etc., which are tasteless when sprayed in the mouth and cannot be used. Bring the enjoyment of taste to patients; in addition, it is necessary to ensure a very high frequency of use throughout the day (including night), which also brings inconvenience to patients

Method used

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  • Spray for treating radioactive xerostomia and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0079] 1. The spray for treating radioactive xerostomia consists of the following components by weight percentage:

[0080] Menthol 0.01%, Mogroside V (purity 98%) 0.015%, Stevioside A (purity 99%) 0.008%, Nasturtium flower water extract 0.5%, Wild chrysanthemum flower water extract 0.3%, Licorice root water extract 0.3% %, perilla water extract 0.15%, lactoferrin 0.008%, lactic acid peroxidase 0.0015%, bovine colostrum extract 0.06%, egg yolk immunoglobulin 0.006%, potassium chloride 0.058%, sodium chloride 0.09% , magnesium chloride 0.007%, calcium chloride 0.025%, dipotassium hydrogen phosphate 0.07%, potassium dihydrogen phosphate 0.02%, sodium fluoride 0.00045%, vitamin B 2 0.015%, vitamin C 0.04%, lysozyme 0.008%, sodium benzoate 0.15%, sodium propyl p-hydroxybenzoate 0.06%, and the balance is distilled water.

[0081] in,

[0082] The preparation method of nasturtium water extract: get 1 kilogram of dried nasturtium (crushed to 40 orders) and add 10 times of medicina...

Embodiment 2

[0089] 1. The spray for treating radioactive xerostomia consists of the following components by weight percentage:

[0090] Menthol 0.03%, mogroside V (purity 99.5%) 0.005%, stevioside A (purity 98.7%) 0.015%, nasturtium flower water extract 0.35%, wild chrysanthemum flower water extract 0.2%, licorice water extract 0.5% %, perilla water extract 0.3%, lactoferrin 0.15%, lactic acid peroxidase 0.0008%, bovine colostrum extract 0.04%, egg yolk immunoglobulin 0.004%, potassium chloride 0.065%, sodium chloride 0.08% , magnesium chloride 0.005%, calcium chloride 0.01%, dipotassium hydrogen phosphate 0.09%, potassium dihydrogen phosphate 0.04%, sodium fluoride 0.0005%, vitamin B 2 0.008%, vitamin C 0.06%, lysozyme 0.012%, sodium benzoate 0.2%, sodium propyl p-hydroxybenzoate 0.04%, and the balance is distilled water.

[0091] in,

[0092] The preparation method of nasturtium water extract: get 1 kilogram of dried nasturtium plus 7 times the amount of medicinal materials in water a...

Embodiment 3

[0099] 1. The spray for treating radioactive xerostomia consists of the following components by weight percentage:

[0100] Menthol 0.02%, mogroside V (purity 95.2%) 0.01%, stevioside A (purity 98.7%) 0.01%, nasturtium flower water extract 0.4%, wild chrysanthemum flower water extract 0.3%, licorice water extract 0.4% %, perilla water extract 0.2%, lactoferrin 0.01%, lactic acid peroxidase 0.001%, bovine colostrum extract 0.05%, yolk immunoglobulin 0.005%, potassium chloride 0.062%, sodium chloride 0.087% , magnesium chloride 0.006%, calcium chloride 0.017%, dipotassium hydrogen phosphate 0.08%, potassium dihydrogen phosphate 0.03%, sodium fluoride 0.00044%, vitamin B 2 0.01%, vitamin C 0.05%, lysozyme 0.01%, sodium benzoate 0.15%, sodium propyl p-hydroxybenzoate 0.05%, and the balance is distilled water.

[0101] in,

[0102] The preparation method of the aqueous extract of Trollius chinensis: take 1 kilogram of dried Trollius chinensis plus 8 times the amount of medicinal ...

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Abstract

The invention discloses a spray for treating radioactive xerostomia and a preparation method thereof. The spray is prepared by adding a plurality of plant extracts based on the conventional artificial saliva and has a cool sweet taste and a plurality of effects, such as diminish inflammation, antibiosis, tooth cleaning, whistle wetting and the like. Compared with the conventional artificial saliva, the spray of the invention has the advantages that: because menthol, momordica glycosides V and stevioside A are added in the formula of the spray, the product has the cool sweet taste and patients enjoy in mouthfeel, and by fully meeting the requirements of the patients with diabetes, obesity and the like, disadvantageous consequences probably caused by a sweetener contained in the product are avoided; because a Chinese globeflower extract, a liquorice root water extract, a wild chrysanthemum water extract and a perilla water extract are added in the spray, the product has the cool sweet taste and also the plurality of effects, such as diminish inflammation, antibiosis, tooth cleaning, whistle wetting and the like, and contributes to the maintenance of oral hygiene and the prevention of oral infection; and because the using times is a few, the spray contributes to the effective remission of thirst.

Description

technical field [0001] The invention relates to a spray, in particular to a spray for treating radiation xerostomia and a preparation method thereof. Background technique [0002] Malignant tumors of the head and neck are a large class of clinically common tumors. According to statistics, there are about 500,000 newly diagnosed patients in the world every year. This type of disease has a high incidence rate, involves many diseases, and the lesions are mostly local infiltration. Therefore, radiotherapy aimed at improving the local control rate has become an important choice for the clinical treatment of head and neck malignant tumors. However, while obtaining good long-term local control and survival effects for patients, radiation-induced salivary gland injury, a side effect of radiation therapy, has inevitably become a difficult problem for radiation therapists and has attracted widespread clinical attention. [0003] Radiation induced xerostomia usually refers to the dam...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K39/395A61K36/71A61K47/10A61K47/28A61K47/26A61K9/12A61P1/02A61K31/375A61K38/40A61K38/44A61K35/20A61K33/14A61K33/06A61K33/42A61K33/16A61K38/47A61K31/192A61K31/235A61K31/525
Inventor 孙步祥汤凌志陆玮陈振鹏易永基吴柏峰
Owner GUILIN NATURAL INGREDIENTS CORP
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