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Anti-fatigue agent comprising amino acid composition

An anti-fatigue agent and amino acid technology, applied in the direction of anti-toxic agents, medical preparations containing active ingredients, drug combinations, etc., can solve the problems of preparation trouble, cost increase, insufficient research, etc., and reduce the trouble of preparation and reduce the variety Effect

Inactive Publication Date: 2010-09-22
MEIJI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0020] As mentioned above, in the existing amino acid composition, the improvement of exercise performance is the main purpose, and the research based on the anti-fatigue or anti-fatigue effect is insufficient
In addition, although there are technologies that specifically claim the effect of recovering from fatigue or preventing fatigue, research based on the effect of preventing both muscle fatigue and nerve fatigue is insufficient, and it is difficult to say that it has been solved.
In addition, in these existing amino acid compositions, it is necessary to provide a variety of amino acids in a large amount as a composition, and there is a problem that the preparation is troublesome and the cost will inevitably increase.

Method used

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  • Anti-fatigue agent comprising amino acid composition
  • Anti-fatigue agent comprising amino acid composition
  • Anti-fatigue agent comprising amino acid composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～4 and comparative example 1

[0136] Mice (male, 8-week-old, C57BL / 6N, feeding environment: 23±3°C, 12-hour light-dark cycle) were grouped as evenly as possible in each group, and divided into experimental groups consisting of 3 to 4 mice per group. Sample group (embodiment) and control group (comparative example). These mice were not fasted, but were forcibly orally administered the anti-fatigue agent of the present invention (sample) or physiological saline (control). One hour after the administration, an exercise load was applied by a treadmill test (25 m / min, 60 minutes).

[0137] Each sample was administered to mice so as to achieve 500 mg / kg body weight in terms of amino acid (10 µL / g body weight for the suspension (5% by weight)). Here, the amino acid composition of the administered anti-fatigue agent of the present invention is shown in Table 1 (the numerical value of the amino acid composition is expressed in parts by weight).

[0138] (Test 1: Measurement of activity level when fatigued)

[01...

Embodiment 5

[0149] (Test 3: Anti-fatigue effect verification test)

[0150] Next, human beings are subjected to an acceleration pulse test and a blood test that can be measured in a manner that does not impose unnecessary psychological and physical pain on the subject, and can objectively evaluate muscle fatigue and nerve fatigue during fatigue load. , urine test, saliva test and physical examination (physical exam), to further verify the anti-fatigue effect of the anti-fatigue agent of the present invention.

[0151] (1) Subjects

[0152] The subjects were healthy adult men and women (12 males, 6 females, 18 in total) who were judged by the physician in charge of the experiment to be suitable for participating in this experiment and agreed to participate in this experiment. This trial was carried out in accordance with the purpose of the Declaration of Helsinki on the basis of approval by the Institutional Review Board (IRB).

[0153] (2) Test food

[0154] The test food used in this ...

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PUM

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Abstract

Conventional amino acid compositions are primarily intended to improve athletic performance or to promote fat-burning. Provided is an anti-fatigue agent which can prevent both of muscle fatigue and nerve strain concurrently. An anti-fatigue agent which comprises an amino acid composition composed of specific amino acids in specified amounts can prevent both of muscle fatigue and nerve strain concurrently. As for the types and the ratio of the amounts of the amino acids contained in the amino acid composition, the amino acid composition preferably contains 30 to 200 parts by weight of proline, 60 to 140 parts by weight of glycine, 50 to 260 parts by weight of alanine, 50 to 130 parts by weight of lysine, 30 to 75 parts by weight of tryptophan and 20 to 40 parts by weight of histidine, more preferably further comprises 3 to 75 parts by weight of tyrosine and 15 to 45 parts by weight of arginine, still more preferably further contains 30 to 55 parts by weight of valine, 35 to 60 parts by weight of leucine and 25 to 60 parts by weight of isoleucine.

Description

technical field [0001] The present invention relates to an anti-fatigue agent containing an amino acid composition composed of specific types and specific amounts of amino acids. Background technique [0002] For human beings living in modern society, the phenomenon of "fatigue" has become a condition that cannot be ignored. According to survey results in recent years, nearly 60% of all Japanese citizens feel tired, and nearly 40% of them say that they have felt tired for more than 6 months. If this is converted into the employed population, nearly 30 million workers are engaged in work with constant fatigue. In addition, when it is severe chronic fatigue, it can also bring obstacles to daily life. Furthermore, the economic loss caused by these fatigues is estimated to be in the range of hundreds of billions of yen to one trillion yen if costs related to recovery measures are included. [0003] When fatigue is classified according to its manifestations, it is broadly divi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/198A23L1/305A61K31/401A61K31/405A61K31/4172A61P3/02A61P43/00
CPCA23V2002/00A23L1/3051A61K31/4172A61K31/405A61K31/401A61K31/198A23L33/175A61P21/00A61P25/00A61P3/02A61P39/00A61P43/00A23V2250/064A23V2250/0622A23V2250/0604A23V2250/063A23V2250/065A23V2250/0624A23V2250/0652A23V2250/0606A23V2250/0654A23V2250/0628A23V2250/0626A23V2200/322
Inventor 斋藤真人有田宏行高村政范
Owner MEIJI CO LTD
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