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Novel medical powder injection rubber plug and manufacturing method thereof

A technology for rubber stopper and powder injection, which is applied in the field of new medical powder injection preparation rubber stopper and its manufacturing method, can solve the problems of single vulcanizing agent for medicinal rubber stopper, excessive insolubility, poor chemical resistance, etc., and achieves chemical resistance. Excellent performance, long scorch time and high cleanliness

Active Publication Date: 2010-10-06
SHANDONG PHARMA GLASS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a medical rubber stopper formula to solve the shortcomings of single medical rubber stopper vulcanizing agent, high pollution degree, short cross-linking bond type, low bond energy, heat aging resistance, and poor chemical resistance, and solve the problems of the current powder injection. There are quality problems in preparations, medicines and rubber stoppers, such as acupuncture chipping and insolubility issues exceeding the standard.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-4

[0036] Examples 1-4: Formulation

[0037] Table 1: Formula table of embodiment 1-4 (unit: parts by weight)

[0038]

[0039] The raw materials used in the above formula are all commercially available products, for example: butyl rubber is a product with a model number of 2211, the carbon black is a common precipitated silica, the vulcanizing agent is a product model SU95AF, and the carbon black masterbatch product model is CBM- 02.

Embodiment 5

[0040] Embodiment 5: method for making, comprises the following steps

[0041] 1. Mixing: Mix all kinds of raw materials and various auxiliary materials;

[0042] 2. Forming: Generally, there are two types: one is to directly fill the mixed rubber into the mold and heat and press to form (without punching); the other is to press into large pieces first, and then put the pressed film into the mold. Molding is usually produced at 195±3°C for about 3-4 minutes.

[0043] 3. Then it is selection and punching. Selection is to cut off bad rubber plugs (pollution, deformation, etc.), and punching is to punch out the formed rubber plugs from the film to become individual rubber plugs.

[0044] 4. Finally, it is cleaning, drying and packaging.

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PUM

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Abstract

The invention discloses a novel medical powder injection rubber plug and a manufacturing method thereof, which belong to the technical field of medical packaging materials. The invention is characterized in that the rubber plug is manufactured by using the following raw materials in part by weight: halogenated butyl rubber 50-60, argil 30-40, carbon black 0.5-1.0, magnesium oxide 2.0-3.0, vulcanizing agent 0.1-0.3, titanium white 0.5-2.5, and carbon black master batch 0.2-1.0. The halogenated butyl rubber may be chlorinated butyl rubber or brominated butyl rubber. The rubber plug of the invention has high chemical resistance, high chemical compatibility, high biological safety and good chemical properties.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical packaging materials, and in particular relates to a novel medical powder injection rubber stopper and a preparation method thereof. Background technique [0002] At present, there are different degrees of compatibility problems in the storage of medicines in domestic medical rubber stoppers. Some pharmaceutical manufacturers require medical rubber stopper manufacturers to improve product quality and stability. Area, so as to solve the problem of compatibility between the rubber plug and the drug, and effectively ensure the efficacy of the drug. Due to the diversity of drugs in pharmaceutical preparation factories, it is impossible to satisfy all the rubber stoppers with one formula. As for which rubber stopper is suitable for which drug, it requires the joint efforts of the pharmaceutical factory and the rubber stopper factory to find a more suitable formula. [0003] Butyl rubber is widel...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L23/28C08K3/00A61J1/00
Inventor 扈永刚晁祥庆郑述玲逯纪伟
Owner SHANDONG PHARMA GLASS
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