Application of ginsenoside Rb3 in preparing medicines for treating depressive disorder

A technology of ginsenoside and depression, which is applied in the field of medicine to achieve the effect of making full use of resources, reducing waste, and avoiding treatment

Inactive Publication Date: 2010-10-13
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Chinese patent 200610027507.1 discloses that protopanaxadiol can be used as an active ingredient in the preparation of antidepressant drugs. Subsequently, in order to further study and improve the application of this type of compound in the preparation of antidepressant drugs, the application number 200610116353.3 further discloses a class of protopanaxadiol Alcohol derivatives have antidepressant activity when applied as a single component. Compared wit

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  • Application of ginsenoside Rb3 in preparing medicines for treating depressive disorder
  • Application of ginsenoside Rb3 in preparing medicines for treating depressive disorder
  • Application of ginsenoside Rb3 in preparing medicines for treating depressive disorder

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1 Mice Behavior Despair Experiment Determination of Antidepressant Activity of Ginsenoside Rb3

[0032] Two models of behavioral hopelessness and depression were used, namely the mouse forced swimming model and the tail suspension model. Determination of time to explore the antidepressant effect of ginsenoside Rb3. In addition, before the establishment of the behavioral hopelessness model, the determination of the locomotor activity of the mice was performed to rule out the possibility of false positive results due to increased excitability.

[0033] Among them, the open-field measurement experiment of the spontaneous activity of mice, the forced swimming experiment and the tail suspension experiment were all carried out according to the general pharmacological method.

[0034] Select male NIH mice, SPF grade, 18-20 g, purchased from the Guangdong Provincial Experimental Animal Center, license number: SCXK (Guangdong) 2008-0002; they were randomly divided into ...

Embodiment 2

[0041] Example 2 Determination of antidepressant activity of ginsenoside Rb3 by mouse acquired helplessness experiment

[0042] The acquired helplessness experiment in mice used in this example was carried out according to general pharmacological methods.

[0043]Male NIH mice, SPF grade, 18-20 g, were purchased from Guangdong Experimental Animal Center, license number: SCXK (Guangdong) 2008-0002; they were randomly divided into 6 groups, with at least 10 mice in each group, and pressed once a day. 0.1ml / 10g body weight orally administered. Wherein the blank control group (No Inescapable Shock, NIS), the model control group (Inescapable Shock, IS) mice were given distilled water, and the administration group was respectively high concentration ginsenoside Rb3 group (IS+150mg / kg Rb3), medium concentration ginsenoside Rb3 group (IS+75mg / kg Rb3), low concentration ginsenoside Rb3 group (IS+30mg / kg Rb3), positive drug fluoxetine hydrochloride group (IS+10mg / kgFluooxetine). In th...

Embodiment 3

[0046] Example 3 Determination of antidepressant activity of ginsenoside Rb3 by mouse chronic mild unpredictable stimulation model experiment

[0047] This example establishes a chronic mild unpredictable stress model in mice according to general pharmacological methods, and on this basis, explores the effects of ginsenosides on the basis of the determination of mouse body weight, autonomous activity, sugar water preference rate, and novelty-inhibited feeding latency. The antidepressant effect of Rb3, and through the determination of the proportion of hippocampus and the relative content of BDNF in the prefrontal cortex and hippocampus of mice in each group, its mechanism of action was analyzed.

[0048] Male NIH mice, SPF grade, 18-20 g, were purchased from the Guangdong Provincial Experimental Animal Center, license number: SCXK (Guangdong) 2008-0002; except for 7 blank control groups, the rest of the mice were housed in single cages. Do model building. The modeling process...

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Abstract

The invention belongs to the field of medicine or natural medicine chemistry, and particularly relates to application of a natural product-ginsenoside Rb3 in preparing a medicine for treating depressive disorder. In the application, ginsenoside Rb3 is directly extracted and obtained from panax notoginseng, ginseng or American ginseng; the dosage is 3.0-20.0mg per kilo of weight each day. Through organically regulating in vivo neurotransmitter and neural network balance and actions of multiple ways and multiple targets such as promoting nerve growth and the like, ginsenoside Rb3 is applied in preparing medicine for treating depressive disorder, so that obvious anti-depression effect is obtained. In addition, ginsenoside Rb3 can be extracted and obtained through traditional Chinese medicine or natural plants, and can be supplied for patients with depressive disorder to be continuously taken for a long period. The ginsenoside Rb3 has clear effective substance, obvious therapeutic effect, small toxic or side effect and definite action mechanism, and is in favor of radically treating depressive disorder and avoiding recurrence of depressive disorder.

Description

technical field [0001] The invention belongs to the field of medicine or natural medicinal chemistry, and in particular relates to the application of a natural product in the preparation of medicines for treating depression. Background technique [0002] Depression is a common mental illness. The so-called Depressive Disorder refers to a mood disorder syndrome characterized by low mood. It usually manifests as long-term low mood, grief, and loss of interest. , self-blame and low self-esteem, slow thinking, slow action, listlessness, loss of appetite, and even extreme self-harm thoughts such as suicide in severe cases. Depression is a disease with high incidence, high recurrence rate, high disability rate and high burden rate. According to the statistics of the World Health Organization, depression has become the fourth largest disease in the world, and it is predicted that by 2020, it may become the second largest disease in the world after coronary heart disease. Depressi...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61P25/24
Inventor 项辉崔继红杨斌
Owner SUN YAT SEN UNIV
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