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Method for preparing nano diflubenzuron microcapsules

A technology of diflubenzuron and microcapsules, applied in the field of preparation of diflubenzuron sustained-release microcapsules, achieving good application prospects, mild reaction conditions, and good reproducibility

Inactive Publication Date: 2010-10-27
迟德富 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] However, the damage brought by chemical pesticides to human beings has also gradually emerged. Due to the extensive use of chemical pesticides, the air, water, soil and food have been polluted, and poisoning has occurred frequently due to the accumulation of poisons in domestic animals and human bodies. Two million people were poisoned by the use of chemical pesticides, and about 40,000 of them died. Moreover, long-term use of certain chemical pesticides will also cause pests to develop resistance. There are currently 417 species of resistant pests. Beginning of a complete ban on the use of organochlorine pesticides, despite this, past accumulations of pesticides are still effective for a considerable period of time
Is there a new type of pesticide that only deals with pests and diseases and has no side effects on humans? In recent years, in agricultural production, it has gradually become a trend to use biological pesticides instead of chemical pesticides. Countries around the world have developed A series of biological pesticides with strong selectivity, high efficiency, low cost, no pollution, and harmless to humans and animals

Method used

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  • Method for preparing nano diflubenzuron microcapsules
  • Method for preparing nano diflubenzuron microcapsules
  • Method for preparing nano diflubenzuron microcapsules

Examples

Experimental program
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Effect test

Embodiment 1

[0024] (1) Crystal recrystallization of diflubenzuron original drug: Dissolve 0.1g diflubenzuron original drug in 50mL acetone, stir magnetically for 1h, and add 200mL containing 0.025% m / v hydroxypropyl methylcellulose immediately after the dissolution is complete (HPMC) deionized water, magnetic stirring, use probe-type ultrasonic to adjust the crystal particle size of diflubenzuron pesticide, the ultrasonic time is 3 minutes, the particle size is 0.1 micron, and the recrystallized crystal of diflubenzuron original drug is obtained,

[0025] (2) Nanodiflubenzuron was prepared by layer-by-layer self-assembly method: disperse 10 mg of recrystallized crystals of the obtained diflubenzuron in 500 μL deionized water, add 1 mL of chitosan with a concentration of 1.6 mg / mL, and ultrasonically adsorb for 5 min. After two cycles of centrifugation-removal of supernatant-washing-oscillation, 1 mL of sodium alginate with a concentration of 1.5 mg / mL was added, and the adsorption was perf...

Embodiment 2

[0027] (1) Crystal recrystallization of diflubenzuron original drug: Dissolve 0.3g diflubenzuron original drug in 50ml of isopropanol, stir magnetically for 1 hour, and immediately add 200mL of diflubenzuron containing 0.025% m / v hydroxypropylmethyl Cellulose (HPMC) deionized water, magnetic stirring, use probe-type ultrasonic to adjust the crystal particle size of diflubenzuron pesticide, the ultrasonic time is 6 minutes, the particle size is 20 microns, and the recrystallized crystal of diflubenzuron original drug is obtained,

[0028] (2) Prepare nano diflubenzuron by layer-by-layer self-assembly method: disperse 30 mg of recrystallized crystals of diflubenzuron in 500 μL of deionized water, add 1 mL of polyarginine with a concentration of 1.8 mg / mL, and ultrasonically adsorb for 10 min After two cycles of centrifugation-removal of supernatant-water washing-oscillation, 1 mL of dextran sulfate with a concentration of 1 mg / mL was added, and the adsorption was performed for 10...

Embodiment 3

[0030] (1) Crystal recrystallization of diflubenzuron original drug: Dissolve 0.5g diflubenzuron original drug in 50ml methanol, stir magnetically for 1 hour, and add 200mL containing 0.025% m / v hydroxypropyl methylcellulose immediately after the dissolution is complete (HPMC) deionized water, magnetic stirring, use probe-type ultrasonic to adjust the particle size of diflubenzuron pesticide crystals, the ultrasonic time is 10 minutes, the particle size is 100 microns, and the recrystallized crystals of diflubenzuron original drug are obtained.

[0031] (2) Preparation of nano-diflubenzuron by layer-by-layer self-assembly method: disperse 100 mg of recrystallized crystals of diflubenzuron in 500 μL of deionized water, add 1 mL of cationic dextran with a concentration of 4.5 mg / mL, and ultrasonically adsorb for 15 min After two cycles of centrifugation-removal of supernatant-washing-oscillation, 1 mL of sodium carboxymethyl cellulose with a concentration of 3 mg / mL was added, an...

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Abstract

The invention relates to a method for preparing nano diflubenzuron microcapsules, which is characterized by (1) re-separating out the raw pesticides in the form of crystals and adjusting the particle size by adopting a probe type ultrasonic method or a vibration method, (2) using diflubenzuron as the template particles, using two biocompatible macromolecules with opposite charges as the wall materials and forming an extremely thin protective outer film on the surface of diflubenzuron, thus obtaining the diflubenzuron microcapsules. The method is simple in process, mild in reaction conditions, easy in operation and good in repeatability, provides material base and technical support for developing the efficient green pesticides and has good application prospect.

Description

technical field [0001] The invention belongs to the field of novel pesticide preparations, in particular to a preparation method of diflubenzuron sustained-release microcapsules. Background technique [0002] At present, chemical pesticides are effective drugs developed by humans to eliminate pests and diseases. Since the use of chemical pesticides, human beings have felt the benefits of chemical pesticides to human beings, such as increasing crop production, preventing and controlling human infectious diseases. According to the survey data of the Food and Agriculture Organization of the United Nations, the grains that are taken away by diseases and insect pests account for 20% of the global harvest every year. %-30%, thus, the economic loss caused reaches 120 billion U.S. dollars. In order to deal with pests and diseases, more than 2 million tons of various chemical pesticides will be produced every year, and its sales volume is as high as 10 billion U.S. dollars every year...

Claims

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Application Information

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IPC IPC(8): A01N47/34A01N25/28A01P7/04
Inventor 迟德富关桦楠宇佳田可
Owner 迟德富
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