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Dark-skinned chicken dispersible tablet and preparation process thereof

A black-bone chicken, white phoenix, and preparation technology, applied to medical preparations containing active ingredients, plant/algae/fungus/moss ingredients, plant raw materials, etc.

Active Publication Date: 2010-10-27
JIANGXI POZIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Among the main traditional Chinese medicines of Wuji Baifeng, except Salvia miltiorrhiza, the rest of more than ten traditional Chinese medicines are all water extracts. When large doses of water extracts are combined with traditional low-substituted hydroxypropyl cellulose, sodium carboxymethyl starch, Conventional disintegrants such as cross-linked polyvinylpyrrolidone, cross-linked carmellose sodium, microcrystalline cellulose, povidone and other conventional disintegrants have adopted various optimized combinations, but in the initial process of disintegration of dispersible tablets in water, There is always a layer of traditional Chinese medicine film wrapped on the surface of the dispersible tablet. This film-like substance is the bottleneck that restricts the further rapid disintegration of the dispersible tablet, especially the rapid dissolution of active ingredients of traditional Chinese medicine represented by paeoniflorin.

Method used

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  • Dark-skinned chicken dispersible tablet and preparation process thereof
  • Dark-skinned chicken dispersible tablet and preparation process thereof
  • Dark-skinned chicken dispersible tablet and preparation process thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0136] Embodiment 1: a kind of preparation technology of black-bone chicken Baifeng dispersible tablet, wherein: the weight ratio of each component is: black-bone chicken (depilled claw sausage) 540g, salvia miltiorrhiza 108g, rehmannia glutinosa 216g, Cyperus cyperi (made from vinegar) 108g, ginseng 108g , white peony root 108g, oyster (calcined) 40g, antler cream 40g, silver bupleurum 22g, licorice 27g, astragalus 27g, turtle shell (made) 54g, papain 13.5g, paraffin 250g;

[0137]Preparation method: Cut the black-bone chicken into pieces, add 4 times the water and cook for 1 hour, add paraffin while it is hot, stir to melt, let it stand overnight, discard the upper layer of paraffin and solid fat, beat it into a homogenate, add papain and stir, Adjust the pH to 6-7, hydrolyze at 50°C for 5 hours, boil for 5 minutes, centrifuge, concentrate the supernatant under reduced pressure to a thick paste with a relative density of 1.30-1.35 (80°C), set aside; Soak in ethanol overnight...

Embodiment 2

[0138] Embodiment 2: (adding inside and outside) a kind of preparation technology of black-bone chicken Baifeng dispersible tablet, wherein: the weight ratio of each component is: black-bone chicken (depilled claw sausage) 540g, salvia miltiorrhiza 108g, rehmannia glutinosa 216g, Cyperus cyperi (made from vinegar) 108g, 108g ginseng, 108g white peony, 40g oyster (calcined), 40g antler cream, 22g silver bupleurum, 27g licorice, 27g astragalus, 54g turtle shell (manufactured), 13.5g papain, 250g paraffin;

[0139] Preparation method: Cut the black-bone chicken into pieces, add 4 times the water and cook for 1 hour, add paraffin while it is hot, stir to melt, let it stand overnight, discard the upper layer of paraffin and solid fat, beat it into a homogenate, add papain and stir, Adjust the pH to 6-7, hydrolyze at 50°C for 5 hours, boil for 5 minutes, centrifuge, concentrate the supernatant under reduced pressure to a thick paste with a relative density of 1.30-1.35 (80°C), set as...

Embodiment 3

[0140] Embodiment 3: (additional) a preparation process of black-bone chicken Baifeng dispersible tablets, wherein: the weight ratio of each component is: black-bone chicken (hairless claw sausage) 540g, salvia miltiorrhiza 108g, rehmannia glutinosa 216g, Cyperus cyperi (made from vinegar) 108g , ginseng 108g, white peony root 108g, oyster (calcined) 40g, antler cream 40g, silver bupleurum 22g, licorice 27g, astragalus 27g, turtle shell (manufactured) 54g, papain 13.5g, paraffin wax 250g;

[0141] Preparation method: Cut the black-bone chicken into pieces, add 4 times the water and cook for 1 hour, add paraffin while it is hot, stir to melt, let it stand overnight, discard the upper layer of paraffin and solid fat, beat it into a homogenate, add papain and stir, Adjust the pH to 6-7, hydrolyze at 50°C for 5 hours, boil for 5 minutes, centrifuge, concentrate the supernatant under reduced pressure to a thick paste with a relative density of 1.30-1.35 (80°C), set aside; Soak in e...

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PUM

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Abstract

The invention relates to a dark-skinned chicken dispersible tablet which comprises the following components in proportions by weight: 540g of dark-skinned chicken of which the feathers, claws and intestine are removed, 108g of salvia miltiorrhiza, 216g of radix rehmanniae, 108g of rhizoma cyperi prepared by vinegar, 108g of ginseng, 108g of white peony root, 40g of calcined oyster, 40g of cornu cervi degelatinatum, 22g of starwort, 27g of licorice, 27g of milk vetch, 54g of prepared turtle shell, 13.5g of papain and 250g of paraffin. In the dark-skinned chicken dispersible tablet of the invention, a large amount of conventional disintegrants such as traditional microcrystalline cellulose, low-substituted hydroxypropyl cellulose, sodium carboxymethyl starch, crospolyvinylpyrrolidone, croscarmellose sodium, povidone and the like are optimized and screened, thereby obtaining the effects of quick disintegration and quick dissolution; and a proper amount and proportion of sodium bicarbonate and citric acid are used for rupture of membranes, and the process of internal and external addition is combined to obtain more excellent effects of quick disintegration and quick dissolution.

Description

technical field [0001] The invention relates to the technical field of medicine dispersible tablets, in particular to a dispersible tablet of black-bone chicken and white phoenix and a preparation process thereof. Background technique [0002] It is well known that Wuji Baifeng Pills is a representative of traditional Chinese medicine with large doses. Over the years, the high dosage of Wuji Baifeng Pills has left a deep impression on people. At the same time, the exact curative effect of Wuji Baifeng Pills has also left a deep impression . In order to meet the requirements of high dosage and fast disintegration, the transformation of large-dose traditional Chinese medicine compound represented by Wuji Baifeng into dispersible tablets is more difficult than the process of transforming traditional small-dose traditional Chinese medicine compound into dispersible tablets. Much more. [0003] The main traditional Chinese medicine raw material of Wuji Baifeng is characterized ...

Claims

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Application Information

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IPC IPC(8): A61K36/8905A61K9/20A61K35/56A61K35/32A61K35/12A61K35/57A61K35/586A61K35/618
Inventor 付生平钱建平
Owner JIANGXI POZIN PHARMA