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Compound walnut and linseed oil fat emulsion intravenous injection and preparation method thereof

A technology of intravenous injection and linseed oil, which is applied in the field of medicine and can solve problems such as imbalanced proportions

Inactive Publication Date: 2010-11-10
王京南
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Daily consumption of the above-mentioned vegetable oils supplements a large amount of omega-6 series linoleic acid, while omega-3 series linolenic acid is very little; long-term single supplementation of omega-3 or omega-6 series fatty acids will cause omega-6 series fatty acids in the body. If the ratio of omega-3 and omega-6 fatty acids is out of balance, the human body is vulnerable to many diseases, leading to the occurrence of related diseases

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Recipe: 100g of refined walnut oil, 100g of linseed oil, 12g of medicinal lecithin, 21g of medicinal glycerin, 0.5g of medicinal vitamin E, appropriate amount of dilute sodium hydroxide solution, and add water for injection to 1000ml.

[0038] 1. Prepare the oil phase liquid: take the medicinal refined walnut oil, linseed oil, medicinal lecithin and medicinal vitamin E in the prescribed amount, and under the protection of nitrogen, heat to 80°C and stir to dissolve into the oil phase liquid for later use;

[0039] 2. Prepare the aqueous phase liquid: take the medicinal glycerin and water for injection of the formula and stir evenly to form an aqueous phase liquid for later use;

[0040] 3. Colostrum emulsion: Under the protection of nitrogen, under the high-speed stirring of the water phase liquid, slowly drop the oil phase liquid into the water phase liquid. After the dripping, use a high-speed shear agitator to colostrumize for 15 minutes;

[0041] 4. Adjust the pH: u...

Embodiment 2

[0047]Recipe: 80g of refined walnut oil, 120g of linseed oil, 13g of medicinal lecithin, 18g of medicinal glycerin, 5g of hydroxypropyl-β-cyclodextrin, appropriate amount of dilute sodium hydroxide solution, and add water for injection to 1000ml.

[0048] 1. Prepare the oil phase liquid: take the medicinal refined walnut oil, linseed oil and medicinal lecithin in the prescribed amount, and under the protection of nitrogen, heat to 80°C and stir to dissolve into the oil phase liquid for later use;

[0049] 2. Preparation of aqueous phase liquid: Take the formula amount of hydroxypropyl-β-cyclodextrin, add water for injection and stir to dissolve, then add medicinal glycerin

[0050] 3. Stir evenly to form an aqueous phase liquid for later use;

[0051] 4. Colostrumization: Under the protection of nitrogen, under the high-speed stirring of the water phase liquid, slowly drop the oil phase liquid into the water phase liquid. After the addition, use a high-speed shear agitator to ...

Embodiment 3

[0058] Recipe: Refined walnut oil 50g, linseed oil 150g, medicinal lecithin 8g, poloxamer 5g, medicinal glycerin 20g, hydroxypropyl-β-cyclodextrin 2g, hydroxypropylmethylcellulose 3g, acetic acid Appropriate amount of sodium dilute solution, add water for injection to 1000ml.

[0059] 1. Preparation of oil phase liquid: take the prescribed amount of medicinal refined walnut oil and linseed oil, add medicinal lecithin and poloxamer, and under the protection of nitrogen, heat to 80°C and stir to dissolve into oil phase liquid for later use;

[0060] 2. Prepare the aqueous phase liquid: take the formula amount of hydroxypropyl-β-cyclodextrin and hydroxypropyl methylcellulose, add water for injection and stir to dissolve, then add medicinal glycerin and stir evenly to form an aqueous phase liquid for later use;

[0061] 3. Colostrumization: Under the protection of nitrogen, under the high-speed stirring of the water phase liquid, slowly drop the oil phase liquid into the water pha...

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PUM

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Abstract

The invention provides a compound walnut and linseed oil fat emulsion intravenous injection and a preparation method thereof. The compound walnut and linseed oil fat emulsion intravenous injection comprises the raw materials of walnut oil, linseed oil, lecithin, glycerol, sterile pure water, antioxidants, stabilizing agents, pH regulating agents and the like. The preparation method comprises the following steps of: under the protection of nitrogen, heating, dissolving and mixing the walnut oil, the linseed oil and the lecithin into an oil phase; mixing the glycerol, the antioxidants, the stabilizing agents and the sterile pure water into a water phase, slowly adding the oil phase in the violently stirred water phase and then shearing in high speed to form a primary emulsion; and regulating the pH of the primary emulsion to 6.5-8.5 by using a few pH regulating agents, emulsifying by using a high-pressure viscolizer, filtering by using a microporous membrane, and then filling, sealing and sterilizing to obtain the compound walnut and linseed oil fat emulsion intravenous injection, wherein the total oil content of the intravenous injection is 1%-50%. The compound walnut and linseed oil fat emulsion intravenous injection and the preparation method thereof are used in the fields of medical treatment and health, and the compound walnut and linseed oil fat emulsion intravenous injection can be administrated through abenteric intravenous injection or intestinal tube feeding or oral feeding and can be used as a nutritional and therapeutic medicament.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a compound intravenous injection of walnut linseed oil fat emulsion and a manufacturing method thereof. The invention comprises walnut oil, linseed oil, an emulsifier, and sterile pure water. Below 800 nanometers, chylomicrons are formed and made into compound walnut linseed oil fat emulsion intravenous injection for parenteral administration via intravenous injection; or for enteral administration via tube feeding or oral administration. [0002] The compound walnut linseed oil fat emulsion intravenous injection contains high content of omega-6 polyunsaturated fatty acid and omega-3 polyunsaturated fatty acid at the same time, which is used to provide and supplement various essential fatty acids in the body, as a nutritional auxiliary treatment for critically ill patients , or for the prevention and treatment of various diseases such as hyperlipidemia, hyperglycemia, nephritis, inflammation,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/55A61K9/107A61P3/02
Inventor 王京南王孝荣
Owner 王京南
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