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Method for preparing chitosan-based composite dressing for medical use

A chitosan and medical technology, applied in the medical field, can solve the problems of weak ability to absorb exudate and poor stability, and achieve the effects of improving the quality of wound healing, not easy to fall off, and easy to operate.

Inactive Publication Date: 2010-11-10
SOUTHWEST UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, at present, this type of biological dressing still has disadvantages such as poor stability and weak ability to absorb exudate, and at the same time, the antibacterial property still needs to be further improved.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0023] Add 0.1g of chitosan powder to 10ml of pure water, then add 0.2g of glacial acetic acid to it, stir quickly until the chitosan is completely dissolved; dilute 20g of honey with 10ml of pure water, and then pour it into the chitosan solution , stir well; at the same time, add 15g of gelatin to 15ml of pure water, heat it at 40°C to dissolve completely, then pour it into the chitosan / honey mixed solution, add 30ml of pure water to 100%, stir evenly, and obtain a transparent mixed fluid; On the next day, the measured pH value was 6.5, and the viscosity was stabilized at 1000-1200mpa.s; the fluid was sterilized to obtain a composite medical fluid dressing.

example 2

[0025] Add 1g of chitosan powder to 25ml of pure water, then add 1g of glacial acetic acid, stir quickly until the chitosan is completely dissolved; dilute 15g of honey with 10ml of pure water, then pour it into the chitosan solution, stir Evenly; at the same time, add 25g of gelatin to 25ml of pure water, heat it at 40°C to dissolve completely, then pour it into the chitosan / honey mixed solution, add pure water to 100% while stirring, stir evenly, and let stand; measure the pH value 6.2; the hydrogel is sterilized to obtain a composite medical hydrogel dressing.

example 3

[0027] Add 0.5g of chitosan powder to 20ml of pure water, then add 0.5g of glacial acetic acid, stir quickly until the chitosan is completely dissolved; dilute 30g of honey with 20ml of pure water, and then pour it into the chitosan solution , stir well; at the same time, add 15g of gelatin into 15ml of pure water, heat it at 40°C to dissolve completely, then pour it into the chitosan / honey mixed solution, add pure water to 100% while stirring, stir evenly, and let stand; measure The pH value is 6.0; the cream body is sterilized to obtain a compound medical cream dressing.

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PUM

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Abstract

The invention provides a method for preparing a chitosan-based composite dressing for medical use. Chitosan, honey, gelatin and other biological materials as the raw materials are subjected to a series of processes to be dissolved into a whole, thus obtaining chitosan-based composite fluid dressings, hydrogel dressings and emulsion dressings for medical use. According to in-vitro antibacterial tests, toxicological tests, skin irritation tests, in-vitro degradation tests and other tests, the antibacterial activity of the product is higher than 99%; the biocompatibility thereof is good; the absorption capacity and seepage thereof are high; the skin-friendliness thereof is good; and the curative effect thereof can be improved, while compared with the prior art, the consumption of chitosan can be greatly reduced, and the cost can be greatly reduced.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to a preparation method of a chitosan composite medical dressing. Background technique [0002] An ideal wound dressing should have good biocompatibility, antibacterial properties, skin affinity, exudate absorption capacity, anti-inflammatory and analgesic functions, etc., which can not only prevent wound infection, shorten the treatment time, but also improve the quality of wound healing. Easy to store and easy to use. Biological dressings show more outstanding advantages than traditional medical dressings (usually gauze), especially for the treatment of large area wounds. [0003] Allogeneic tissue biological dressings are mainly derived from animal skins. Currently, pigskin, amniotic membrane, and fish skin are used for research. The United States, Britain, Japan and other countries have commercialized pigskin supply, mainly including glutaraldehyde cross-linked pigskin and ir...

Claims

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Application Information

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IPC IPC(8): A61L15/40A61L15/32A61L15/28A61L15/44
Inventor 汪涛张同华朱小康
Owner SOUTHWEST UNIVERSITY
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