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Tiamulin fumarate effervescent granules for treating pneumonia and dysentery of livestock and poultry

A technology of tiamulin fumarate and effervescent granules is applied in the directions of antibacterial drugs, respiratory diseases, pharmaceutical formulations, etc., to achieve the effects of good taste, rapid onset of action and definite curative effect

Inactive Publication Date: 2010-11-24
SRICK TIANJIN BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] In the entire veterinary pharmaceutical industry in my country, veterinary drug preparations are a weak link. Existing veterinary drug forms include tablets, oral liquids, powders, etc., which are far from meeting the needs of the absorption and efficacy of certain drugs in veterinary clinics. Therefore, , strengthen the research and development of new dosage forms, realize the characteristics of timing, positioning, fixed speed and continuous action of drugs according to different requirements, continuously improve the curative effect of drugs, and reduce toxic and side effects are the direction of our efforts in the research and development of dosage forms in the future

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] A tiamulin fumarate effervescent granule for treating pneumonia and dysentery for livestock and poultry, the raw materials, auxiliary materials and parts by weight are respectively:

[0021] Tiamulin fumarate: 80 parts; citric acid: 100 parts; sodium bicarbonate: 150 parts; polyethylene glycol 6000: 20 parts; dextrin: 190 parts; sucrose: 360 parts,

[0022] Preparation method, the steps are:

[0023] (1) Take raw materials and auxiliary materials according to parts by weight, and pulverize them to a particle size of 100 mesh, and set aside;

[0024] (2) Take pulverized tiamulin fumarate, citric acid, polyethylene glycol 6000, dextrin, and sucrose of 1 / 2 of the total amount and mix them uniformly in a tank mixer, add purified water to make a soft material, and prepare granules, dried, whole granules;

[0025] (3) Take the pulverized sodium bicarbonate, put the remaining polyethylene glycol 6000, dextrin, and sucrose into the tank mixer and mix evenly, add purified wate...

Embodiment 2

[0030] A tiamulin fumarate effervescent granule for treating pneumonia and dysentery for livestock and poultry, the raw materials, auxiliary materials and parts by weight are respectively:

[0031] Tiamulin fumarate: 100 parts; citric acid: 120 parts; sodium bicarbonate: 160 parts; polyethylene glycol 6000: 30 parts; dextrin: 200 parts; sucrose: 380 parts.

[0032] Preparation method, the steps are:

[0033] (1) All the raw and auxiliary materials are pulverized to a particle size of 110 mesh, and set aside;

[0034] (2) Take pulverized tiamulin fumarate, citric acid, polyethylene glycol 6000, dextrin, and sucrose of 1 / 2 of the total amount and mix them uniformly in a tank mixer, add purified water to make a soft material, and prepare granules, dried, whole granules;

[0035] (3) Take the pulverized sodium bicarbonate, put the remaining polyethylene glycol 6000, dextrin, and sucrose into the tank mixer and mix evenly, add purified water to make a soft material, granulate, dr...

Embodiment 3

[0038] A tiamulin fumarate effervescent granule for treating pneumonia and dysentery for livestock and poultry, the raw materials and parts by weight are respectively:

[0039] Tiamulin fumarate: 120 parts: citric acid: 140 parts; sodium bicarbonate: 170 parts; polyethylene glycol 6000: 40 parts; dextrin: 230 parts; sucrose: 400 parts.

[0040] Preparation method, the steps are:

[0041] (1) All the raw and auxiliary materials are crushed to a particle size of 120 mesh, and set aside;

[0042] (2) Take pulverized tiamulin fumarate, citric acid, polyethylene glycol 6000, dextrin, and sucrose of 1 / 2 of the total amount and mix them uniformly in a tank mixer, add purified water to make a soft material, and prepare granules, dried, whole granules;

[0043] (3) Take the pulverized sodium bicarbonate, put the remaining polyethylene glycol 6000, dextrin, and sucrose into the tank mixer and mix evenly, add purified water to make a soft material, granulate, dry, and granulate;

[00...

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Abstract

The invention relates to tiamulin fumarate effervescent granules for treating pneumonia and dysentery of livestock and poultry, which comprise the following raw materials and auxiliary materials in part by weight: 80 to 120 parts of tiamulin fumarate, 100 to 140 parts of citric acid, 150 to 170 parts of sodium bicarbonate, 20 to 40 parts of polyethylene glycol 6000, 190 to 230 parts of dextrin and 360 to 400 parts of sucrose. A method for preparing the tiamulin fumarate effervescent granules comprises the following steps of: grinding the raw materials and the auxiliary materials, respectively mixing the ground raw materials and the ground auxiliary materials, drying the mixture, pelletizing the dried mixture and sufficiently mixing the products. The tiamulin fumarate effervescent granules prepared by the method are used for diseased livestock and poultry in an oral administration mode, have the advantages of good taste and stable quality and are an ideal preparation for treating mycoplasma pneumonia, actinomycotic pleuropneumonia and treponema dysentery of the livestock and poultry currently.

Description

technical field [0001] The invention belongs to the field of veterinary drug preparations, in particular to effervescent tiamulin fumarate granules for livestock and poultry. Background technique [0002] In the entire veterinary pharmaceutical industry in my country, veterinary drug preparations are a weak link. Existing veterinary drug forms include tablets, oral liquids, powders, etc., which are far from meeting the needs of the absorption and efficacy of certain drugs in veterinary clinics. Therefore, , strengthen the research and development of new dosage forms, realize the characteristics of timing, positioning, fixed speed and continuous action of drugs according to different requirements, continuously improve the curative effect of drugs, and reduce toxic and side effects are our future efforts in research and development of dosage forms. [0003] Effervescent granules are a novel dosage form. The difference between them and ordinary granules is that they contain effe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/46A61K31/22A61K47/36A61P11/00A61P31/00A61P31/04
Inventor 王洪杰苏永鹏黄健刘志辉
Owner SRICK TIANJIN BIO TECH
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