Salbutamol sulfate sustained-release aerosol of micropowder for inspiration and preparation method thereof
A technology of albuterol sulfate and inhalation powder spray, which is applied in the field of salbutamol sulfate sustained-release inhalation powder spray and its preparation, and can solve the problems that there are no research reports on salbutamol sulfate pulmonary sustained-release preparations.
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Embodiment 1
[0063] Get salbutamol sulfate 0.12g, chitosan 0.1g, mannitol 1.48g and leucine 0.3g to be dissolved in 100mL water, spray dry. The conditions were that the inlet temperature was 100° C., the outlet temperature was 65° C., and the nozzle air flow rate was 800 ml / min. Obtain white salbutamol sulfate powder, measure the salbutamol sulfate content, and pack in hard capsules. In vitro release curve see Figure 4 .
Embodiment 2
[0065] 0.12 g of salbutamol sulfate, 0.2 g of sodium hyaluronate, 1.4 g of lactose and 0.28 g of threonine were dissolved in 100 mL of water, and spray-dried. The conditions were that the inlet temperature was 110° C., the outlet temperature was 70° C., and the nozzle air flow rate was 800 ml / min. Obtain white salbutamol sulfate powder, measure the salbutamol sulfate content, and pack in hard capsules. In vitro release curve see Figure 5 .
Embodiment 3
[0067] Get salbutamol sulfate 0.12g, mannitol 1.26g, leucine 0.32g to be dissolved in 80ml water, phospholipid 0.3g is dissolved in 20ml ethanol, after two solutions are mixed, spray dry. The spray drying inlet temperature is 100°C and the outlet temperature is 60°C. The nozzle air flow rate is 800ml / min. Obtain white salbutamol sulfate powder, measure the salbutamol sulfate content, and pack in hard capsules. In vitro release curve see Figure 6 .
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