Low molecular weight peptide of shark cartilage angiogenesis inhibiting factor, production purifying method and application thereof

Abstract

The invention discloses low molecular weight peptide of a shark cartilage angiogenesis inhibiting factor, a production purifying method and application thereof. The amino acid sequence of the low molecular weight peptide of the shark cartilage angiogenesis inhibiting factor is shown as SEQ ID NO: 1, and the DNA sequence for coding the low molecular weight peptide is shown as SEQ ID NO:2. The low molecular weight peptide of the shark cartilage angiogenesis inhibiting factor can inhibit generation or growth of vessels or vascular endothelial cells, can inhibit proliferation of tumor cells, can be used for preparing related medicaments for inhibiting generation or growth of the vessels or preparing anti-tumor medicaments.

Description

A small molecular polypeptide of shark cartilage angiogenesis inhibitory factor and its production and purification method and application technical field The invention relates to the field of small molecule peptides, in particular to a small molecule polypeptide of shark angiogenesis inhibitory factor and its production and purification method and application. Background technique Sharks are one of the marine animals that rarely suffer from malignant tumors, and the incidence rate is one in a million. American scientist Luer injected a high dose of aflatoxin B1, a strong carcinogen, into sharks, but it could not induce cancer in sharks. Inoculating sharks with cancer cells also failed to induce cancer. This suggests that sharks have a unique anti-tumor mechanism (He Lihong 1, Huang Jianhua 2, Shen Songdong et al., Marine Science / 2005 / Volume 29 / Period 11: 63-66). Over the years, researchers from all over the world have mostly studied shark cartilage tissue, and isolated...

AI Technical Summary

Problems solved by technology

The purpose of the present invention is to provide a shark angiogenesis inhibitor small molecular polypeptide that is easy to absorb according to the problems in the prior art that the purity of substances separated and extracted from shark tissues is not equal, and the molecular weight is relatively large and is not easily absorbed by cells.

Images