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Quetiapine fumarate tablet and preparation method thereof

A technology of quetiapine tablets and quetiapine, which is applied in the directions of pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, to achieve the effects of improving bioavailability and solving poor dissolution

Inactive Publication Date: 2011-01-12
ZHEJIANG HUAHAI PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The invention provides a new quetiapine tablet, which can be rapidly dissolved by adding one or more specific acids into the prescription, and the drug dissolution rate can reach 15 minutes, or even 10 minutes. More than 85%, which solves the problem of poor dissolution of the insoluble drug quetiapine in the preparation, improves the bioavailability, and thus achieves the therapeutic effect

Method used

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  • Quetiapine fumarate tablet and preparation method thereof
  • Quetiapine fumarate tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～3

[0037]

Embodiment 1

[0040] Example 1: Put quetiapine fumarate, lactose, microcrystalline cellulose, sodium carboxymethyl starch, and povidone K30 into a fluidized bed for mixing, add purified water to granulate, then dry, and granulate to obtain dry granules , adding sodium stearyl fumarate to the dry granules, mixing evenly, compressing to obtain tablets, and coating the tablets.

Embodiment 2

[0041] Embodiment 2: Mix quetiapine fumarate, fumaric acid, lactose, microcrystalline cellulose, sodium carboxymethyl starch, povidone K30, add purified water to granulate and then dry, and granulate to obtain dry granules. Sodium stearyl fumarate is added to the dry granules, mixed evenly, compressed into tablets to obtain tablets, and the tablets are coated.

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PUM

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Abstract

The invention provides a quetiapine fumarate tablet which comprises active ingredient quetiapine fumarate or pharmaceutically acceptable salt, and at least one pharmaceutic adjuvant; the quetiapine fumarate tablet also comprises one or more specific acids which can promote a medicine to be rapidly dissolved out; and fumaric acid is preferentially selected. The invention also relates to a preparation method of the quetiapine fumarate tablets. By the invention, the product which can be rapidly dissolved out and has good stability can be acquired, and the quality of the product can be improved.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to quetiapine tablets and a preparation method thereof. Background technique [0002] Quetiapine is an atypical antipsychotic. Its structure is similar to that of clozapine. It belongs to dibenzodiazepine derivatives. Cell deficiency, obesity, anticholinergic and other adverse reactions. Now with (SEROQUEL) is marketed under the trade name Seroquel as monotherapy or as an adjunctive therapy to lithium or divalproex (Divalproex) for the treatment of schizophrenia and acute mania associated with bipolar I disorder seizure treatment. [0003] US4879288 discloses a synthesis method of quetiapine, and quetiapine tablets are also disclosed in the examples, including common excipients lactose, povidone, sodium ethoxide starch, pregelatinized starch, corn starch, magnesium stearate and the like. [0004] CN200710043404 discloses quetiapine fumarate slow (controlled) release p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/28A61K31/554A61K47/12A61K47/20A61K47/04A61K47/38A61P25/18
Inventor 葛光华李巧霞彭俊清胡功允顾喜燕
Owner ZHEJIANG HUAHAI PHARMA CO LTD
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