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Chinese loropetalum leaf total flavonol extract and medical application thereof

A technology based on total flavonols and following wood leaves is applied in pharmaceutical formulations, medical preparations containing active ingredients, and drug combinations to achieve the effects of inhibiting myocardium, inhibiting the formation of thrombus, and reducing toxic and side effects.

Active Publication Date: 2011-01-12
湖南药圣堂中药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

After searching, there is no literature report on the treatment of diabetic retinopathy, coronary heart disease, angina pectoris and cerebral infarction with the total flavonols of Jijiye

Method used

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  • Chinese loropetalum leaf total flavonol extract and medical application thereof
  • Chinese loropetalum leaf total flavonol extract and medical application thereof
  • Chinese loropetalum leaf total flavonol extract and medical application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Take 100kg of succulent leaves, add 50% ethanol to reflux extraction twice, each time for 1 hour, add 800kg50% ethanol for the first time, add 600kg50% ethanol for the second time, filter, combine the extracts, and recover the extracts Ethanol and concentrated to a dilute extract with a relative density of 1.05, this dilute extract was passed through D101 macroporous adsorption resin, first eluted to colorless with 20% ethanol, the 20% ethanol eluate was discarded, and then washed with 80 % ethanol is eluted to colorless, the 80% ethanol eluate is collected, the ethanol is recovered and concentrated into a thick paste with a relative density of 1.25, and vacuum-dried to obtain the total flavonoid alcohol extract containing 50% of total flavonol .

Embodiment 2

[0029] Take 100kg of succulent leaves, add 70% ethanol to reflux and extract twice, each time for 1.5 hours, add 700kg of 70% ethanol for the first time, add 600kg of 70% ethanol for the second time, filter, combine the extracts, and recover the extracts Ethanol and concentrated to a dilute extract with a relative density of 1.08, this dilute extract was passed through AB-8 macroporous adsorption resin, first eluted to colorless with 30% ethanol, the 30% ethanol eluate was discarded, and then Elute with 70% ethanol until it is colorless, collect the 70% ethanol eluate, recycle the ethanol and concentrate it into a clear paste with a relative density of 1.10, and spray dry to obtain the total flavonols containing 70% of the total flavonols Extract.

Embodiment 3

[0031] Take 100kg of succulent leaves, add 90% ethanol to reflux and extract twice, each time for 2 hours, add 800kg90% ethanol for the first time, add 600kg90% ethanol for the second time, filter, combine the extracts, and recover the extracts Ethanol and concentrated to a dilute extract with a relative density of 1.10, this dilute extract was passed through D201 macroporous adsorption resin, first eluted with water until colorless, discarded the water eluent, and then eluted with 90% ethanol to Colorless, collect the 90% ethanol eluate, recover the ethanol, and dry it in vacuum to obtain the dry extract. Add 5 times the amount of water to the dry extract to suspend, extract 4 times with ethyl acetate, each time the amount of ethyl acetate is equal to the sample volume, combine the ethyl acetate layers, recover ethyl acetate, and vacuum dry, that is The total flavonol extract containing 90% of total flavonol is obtained.

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Abstract

The invention discloses a Chinese loropetalum leaf total flavonol extract, which is characterized in that: the total flavonol content is over 50 percent, and the Chinese loropetalum leaf total flavonol extract is extracted and refined from a traditional Chinese medicine, namely Chinese loropetalum leaves. Pharmacodynamic and toxicological tests prove that the Chinese loropetalum leaf total flavonol has the advantages of obviously improving the diabetic retinopathy of rats caused by streptozotocin, expanding coronary arteries and peripheral vessels, increasing the blood flow of the coronary arteries, inhibiting cardiac muscles, reducing the heart rate and the aggregation of blood platelets, inhibiting the formation of thrombi, and obviously protecting cerebral ischemia, along with small toxic and side effects. The invention also discloses medical application of the Chinese loropetalum leaf total flavonol extract.

Description

Technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and relates to an effective part extracted from the leaves of a traditional Chinese medicine, and also relates to a preparation method of the effective part and its medical application. Background technique [0002] Diabetic retinopathy (Diabetic retinopathy, DR) is one of the main chronic complications of diabetes, which can lead to irreversible blindness in both eyes, and is the third leading disease of blindness. Therefore, DR has attracted more and more attention. At present, the main treatment measures for diabetic retinopathy are laser photocoagulation and vitrectomy, but this kind of eye surgery cannot completely control the development of the disease and reduce the blindness rate; meanwhile, there is no special drug for the treatment of diabetic retinopathy. [0003] Cardiovascular and cerebrovascular diseases are the first type of diseases that cause human death. With...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P9/10A61K127/00
Inventor 周小江
Owner 湖南药圣堂中药科技有限公司
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