In-vitro dynamic simulation test apparatus for biodegradation performance of magnesium alloy medical equipment

A medical device, biodegradation technology, applied in the direction of instruments, measuring devices, scientific instruments, etc., can solve the problems of difficult to accurately predict the biodegradation performance of materials/device in vivo, unavoidable shearing action, clinical reference value discount, etc., to improve R&D efficiency, improvement of R&D quality, and effect of ensuring controllability

Inactive Publication Date: 2012-08-08
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this method is simple and easy to implement, it has the following main disadvantages: 1) It ignores the important influence of the relative motion of the material / medium on the corrosion degradation behavior of the material except convection
The biomedical application of magnesium alloy is just around the corner, especially when it is used as a coronary stent, it will inevitably be sheared by flowing body fluids such as blood, tissue fluid, etc.; It is difficult to accurately predict the in vivo biodegradability of materials / devices, which greatly reduces its clinical reference value, thus losing the due significance of in vitro research

Method used

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  • In-vitro dynamic simulation test apparatus for biodegradation performance of magnesium alloy medical equipment
  • In-vitro dynamic simulation test apparatus for biodegradation performance of magnesium alloy medical equipment
  • In-vitro dynamic simulation test apparatus for biodegradation performance of magnesium alloy medical equipment

Examples

Experimental program
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Effect test

Embodiment 1

[0023] Taking the dynamic simulation test of the biodegradability of high-purity magnesium and magnesium alloys AZ91D, AM60B and WE43 by using the present invention as an example, the usage of the present invention is introduced in detail: the equipment is cleaned as a whole; the pre-configured test medium such as Hank's simulated body fluid, etc. Inject the test chamber 1 through the adjustment hole 7 of the test chamber 1; cover all the sealing plugs; turn on the power switch of the constant temperature bath 4, preset the temperature, heat the test medium and keep it at a constant temperature; process and carry the sample head 12 on the sample The matched sample hole is pretreated by metallographic grinding, ultrasonic degreasing or / and surface modification such as anodic / micro-arc oxidation, bionic passivation, etc. to measure the area and weigh the mass; screw the sample into the upper sample holder 3 Sample loading head 12; pull out the sealing plug in the operation hole 6...

Embodiment 2

[0025] Except that the speed of the slider 5 was changed to 7.0 mm / s, the others were the same as in Example 1, and rich and comprehensive information on material corrosion degradation was also obtained, such as mass change, phase composition of degradation products, elemental composition, and microscopic morphology.

Embodiment 3

[0027] Except that the stroke of slider 5 was changed to 21 cm, the others were the same as in Example 1, and rich and comprehensive information on material corrosion degradation was also obtained, such as mass change, phase composition of degradation products, elemental composition, and microscopic morphology.

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Abstract

The invention discloses an in-vitro dynamic simulation test apparatus for biodegradation performance of magnesium alloy medical equipment. The apparatus comprises a test cabin, a horizontal movement platform, an upper sample loader and a constant temperature oven, wherein the horizontal movement platform is fixed above the inside of the test cabin to provide horizontal movement; the upper sample loader is vertically fixed on a horizontal movement output unit of the horizontal movement platform; and the test cabin is arranged in the constant temperature oven. By using the apparatus, the horizontal movement of a sample can be realized in a medium according to a designated track and speed; the influence of the relative movement speed between the biological medical material, the conventional engineering material, the military material and the like and the mediums such as body fluid, seawater and the like, the medium components, temperature and pH value and the like on the medium corrodibility and the material degradability can be evaluated quickly and accurately; and the invention has important value to the development of new material / equipment and application technology thereof and great significance on the improvement of the research and development efficiency and quality and the reduction of the research and development cost.

Description

technical field [0001] The invention belongs to the field of material performance testing technology and equipment, and relates to equipment for dynamic simulation testing and evaluation of material corrosion degradation performance in a fluid medium. Background technique [0002] For materials serving in a liquid environment, such as medical devices implanted in the human body, ships in seawater, etc., the relative motion between them and the medium has a very important impact on their corrosion degradation behavior. Studies have shown that this relative movement can not only change the corrosion degradation rate of the material / device, but also change its corrosion degradation type and its mechanism. Therefore, simulating the actual service conditions, especially the relative movement between the environmental medium and the material / device, is of great significance for revealing the true law of the degradation and erosion of the medium and the corrosion degradation behavi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N17/00
Inventor 张永君刘通王治平耿利红
Owner SOUTH CHINA UNIV OF TECH
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