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Method for preparing ketoprofen slow release preparation

A slow-release preparation, ketoprofen technology, applied in the field of medicine, can solve the problems of undisclosed prescriptions and preparation methods, and achieve the effect of stable blood drug concentration and reduced valley value

Active Publication Date: 2011-04-06
SICHUAN QILI PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

None of the above-mentioned sustained-release preparations has disclosed the prescription and preparation method

Method used

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  • Method for preparing ketoprofen slow release preparation
  • Method for preparing ketoprofen slow release preparation
  • Method for preparing ketoprofen slow release preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Embodiment 1 is prepared according to CN1203787A embodiment 1.

[0048] Ketoprofen 75g

[0049] Hydroxypropyl Methyl Cellulose 15g

[0050] Lactose 45g

[0051] Dextrin 35g

[0052] Appropriate amount of HPMC solution

[0053] Magnesium Stearate 0.5%

[0054]

[0055] Makes 1000 pieces

[0056] Each tablet contains 75 mg of the main drug, and the in vitro dissolution reaches 90% in 7 hours, that is, a 12-hour sustained-release preparation, which needs to be taken twice a day.

Embodiment 2

[0058] Ketoprofen 200g

[0059] Hydroxypropyl Methyl Cellulose 60g

[0060] Lactose 45g

[0061] Dextrin 35g

[0062] Appropriate amount of HPMC solution

[0063] Magnesium Stearate 0.5%

[0064]

[0065] Makes 1000 pieces

[0066] Each tablet contains 200 mg of the main drug, and the resulting in vitro dissolution reaches 80% in 10 hours, that is, a 12-hour sustained-release preparation, which needs to be taken twice a day.

Embodiment 3

[0068] Ketoprofen 200g

[0069] Hydroxypropyl Methyl Cellulose K4M 90g

[0070] Sucrose 10g

[0071] Lactose 45g

[0072] Aqueous solution

[0073] Magnesium Stearate Appropriate amount

[0074] Micropowder silica gel amount

[0075] Appropriate amount of talcum powder

[0076]

[0077] Makes 1000 pieces

[0078] The in vitro dissolution of this prescription does not meet the requirements, and the dissolution is too low.

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Abstract

The invention belongs to the field of medicines, and particularly relates to a method for preparing a ketoprofen slow release preparation. The method for preparing the ketoprofen slow release preparation realizes steady blood concentration after administration and can also realize the purpose of steadily releasing ketoprofen within 24h. The ketoprofen slow release preparation mainly comprises the following components in parts by weight: 200 parts of ketoprofen and 110-120 parts of slow release skeleton matrix, wherein the ketoprofen is used as a main ingredient, and the slow release skeleton matrix consists of hydroxymethyl propyl cellulose K4M and hydroxymethyl propyl cellulose K100M in the ratio of 5: 1. The method for preparing the ketoprofen slow release preparation comprises the following steps of: A, mixing the ketoprofen and the slow release skeleton matrix; and B, adding pharmaceutically-acceptable accessories to prepare the slow release preparation. By applying the ketoprofen slow release preparation, long-acting slow release is realized, the peak value and the valley value of blood concentration are reduced, the blood concentration is more steady, the half-life period is eliminated up to 11h; and the ketoprofen slow release preparation can especially satisfy steady release within 24h and just needs to be taken once a day.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a preparation method of a ketoprofen sustained-release preparation. Background technique [0002] Ketoprofen (Ketoprofen), its chemical name α-methyl-3-benzoyl-phenylacetic acid, its structural formula is as follows: [0003] [0004] Ketoprofen is a non-steroidal anti-inflammatory and analgesic drug with the basic structure of aryl alkanoic acid. The anti-inflammatory effect is strong and the adverse reaction is less and milder than that of ibuprofen and indomethacin, and has the advantages of small dose, high curative effect and low toxicity. It can be used clinically for postoperative pain relief, chronic cancer pain, stomatology pain for mild and moderate toothache, primary dysmenorrhea and postpartum pain relief, acute visceral pain (such as biliary colic, renal colic), acute low back pain and sciatica, etc. . [0005] The current situation of ketoprofen: "Chinese P...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K9/22A61K9/52A61K31/192A61K47/38A61P29/00
Inventor 毛兴荣杜宗涛刘嘉徐成思花蕾文娟
Owner SICHUAN QILI PHARM CO LTD