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Amoxicillin soluble powder as well as preparation method and application thereof

An amoxicillin and soluble technology, applied in the field of amoxicillin soluble powder and its preparation, can solve the problems of easy deterioration and low solubility of amoxicillin, and achieve the effects of enhancing stability and improving solubility

Active Publication Date: 2011-04-13
QINGDAO VLAND BIOTECH INC +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The invention provides a soluble powder of amoxicillin and its preparation method and application, which can solve the problems in the prior art that the solubility of amoxicillin itself in water is relatively low and it is easy to deteriorate in water

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] (1) Crushing and sieving: respectively pulverize amoxicillin and polyethylene glycol 4000, and pass through a 120-mesh sieve.

[0024] (2) Mixing, fine grinding or pulverization: after mixing amoxicillin and polyethylene glycol 4000 according to the mass ratio of 1:4, pulverization;

[0025] (3) Pass through a 120-mesh sieve, and then pack.

Embodiment 2

[0027] (1) Crushing and sieving: respectively pulverize amoxicillin and polyethylene glycol 6000, and pass through a 120-mesh sieve.

[0028] (2) Mixing, fine grinding or pulverization: after mixing amoxicillin and polyethylene glycol 6000 according to the mass ratio of 1:5, pulverization;

[0029] (3) Pass through a 120-mesh sieve, and then pack.

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PUM

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Abstract

The invention provides an amoxicillin soluble powder as well as a preparation method and application thereof, which can solve the problem in the prior art that amoxicillin has low solubility in water and has big possibility of deteriorating in water. The invention adopts the following technical scheme: the amoxicillin soluble powder comprises the following components in percentage by weight: 1-50 wt% of amoxicillin and 50-99 wt% of polyethylene glycol. The invention also provides the preparation method and application of the amoxicillin soluble powder. With respect to the amoxicillin soluble powder prepared by the invention, the solubility of amoxicillin in water is increased and the stability of amoxicillin in water is improved.

Description

technical field [0001] The invention belongs to the field of new medicine technology, in particular, relates to a soluble powder of amoxicillin and its preparation method and application. Background technique [0002] Amoxicillin is a penicillin antibiotic, which is effective against aerobic Gram-positive cocci such as Streptococcus pneumoniae, hemolytic Streptococcus, non-penicillinase-producing Staphylococcus, Enterococcus faecalis, Escherichia coli, Proteus mirabilis, Salmonella Non-β-lactamase-producing strains of aerobic Gram-negative bacteria such as Bacteria spp., Haemophilus influenzae, and Neisseria gonorrhoeae and Helicobacter pylori have good antibacterial activity. Amoxicillin exerts a bactericidal effect by inhibiting the synthesis of bacterial cell walls, and can rapidly dissolve and rupture bacteria into spheroids. [0003] Amoxicillin is suitable for the following infections caused by sensitive bacteria (non-beta-lactamase-producing strains): 1. Otitis media...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K31/43A61K47/34A61P31/04A61P11/00A61K47/10
Inventor 林扬郝智慧贾德强王春元邱梅
Owner QINGDAO VLAND BIOTECH INC
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