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Novel modified polysaccharide biomaterial used for eye administration and preparation process thereof

A technology for eye drug delivery and biomaterials, which is applied in the field of new modified polysaccharide biomaterials and its preparation technology, can solve the problems of low drug solubility, low drug utilization, and short ocular residence time, so as to reduce the frequency of medication , the effect of prolonging the action time

Inactive Publication Date: 2011-04-27
SUZHOU MEDISTAR BIOTECH
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Problems solved by technology

[0008] In order to overcome the deficiencies in the prior art, the object of the present invention is to provide a novel modified polysaccharide biomaterial for eye administration, which solves the problems of low drug solubility, short retention time in the eye, and The problem of low utilization

Method used

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  • Novel modified polysaccharide biomaterial used for eye administration and preparation process thereof
  • Novel modified polysaccharide biomaterial used for eye administration and preparation process thereof
  • Novel modified polysaccharide biomaterial used for eye administration and preparation process thereof

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Embodiment Construction

[0034]

[0035] The general structural formula of the dihydroxyl ring-opening starch derivative dihydroxyl ring-opening starch lipid is:

[0036]

[0037] In the structural formula of dihydroxy ring-opened starch lipid, R is OCOCH 3 , the structural formula represents dihydroxy-ring-opened starch acetate. In the structural formula of dihydroxy ring-opened starch lipid, R is OCOCH 2 CH 3 , the structural formula represents dihydroxy-ring-opened starch propionate.

[0038] combine figure 1 , a preparation process for making the above-mentioned novel modified polysaccharide biomaterial for ocular administration, comprising the following steps:

[0039] (1) Using natural polysaccharides such as starch shown in formula (a) as starting material, generate dialdehyde starch (hereinafter referred to as DAS) shown in formula (b) through sodium periodate oxidation reaction;

[0040] (2) the dialdehyde-based starch obtains dihydroxy ring-opened starch (hereinafter referred to a...

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Abstract

The invention discloses a novel modified polysaccharide biomaterial used for eye administration and a preparation process thereof, and the novel modified polysaccharide biomaterial comprises double hydroxyl open-loop starch and double hydroxyl open-loop starch lipid. The preparation process adopts starch as a raw material and comprises the steps of obtaining the double hydroxyl open-loop starch through a sodium periodate oxidation reaction and a sodium borohydride reduction reaction and then obtaining the double hydroxyl open-loop starch lipid through esterification. The double hydroxyl open-loop starch and the double hydroxyl open-loop starch lipid which is the derivate of the double hydroxyl open-loop starch in the invention have appropriate surface tension, appropriate rheological behaviour, appropriate viscosity and an appropriate drug release curve when being used in ophthalmic administration and mucous membrane administration, thus reducing irritant effect, improving solubility of lipid soluble drugs, improving stability of drugs and increasing bioavailability of drugs.

Description

technical field [0001] The invention relates to the field of ophthalmic drugs, in particular to a novel modified polysaccharide biomaterial for ocular administration and a preparation process thereof. Background technique [0002] The eye disease market is a growing market. According to authoritative data, the overall size of my country's eye disease market is 10 billion RMB. With the changes in people's working and living environments, many eye diseases are showing a rapid growth trend. Nowadays, the popularization of Internet and computer office has led to an increasing demand for eye drops to relieve visual fatigue, which is increasing at a rate of 25% per year; and the number of patients with severe eye diseases such as cataracts and glaucoma is also increasing with aging. The phenomenon and the use of many modern technological electronic products have led to an increase in the number of patients every year by millions. These phenomena will once again give rise to the hu...

Claims

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Application Information

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IPC IPC(8): C08L3/10C08L3/06C08B31/18C08B31/02A61K47/36
Inventor 刘伟鹏
Owner SUZHOU MEDISTAR BIOTECH
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