Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Production method of benzofuranone

A technology of benzofuranone and its production method, which is applied in the direction of organic chemistry, can solve the problems of large investment in factory equipment, difficult recovery of catalysts, environmental problems, etc., and achieve the effects of reducing product loss, reducing equipment investment, and simplifying post-processing

Active Publication Date: 2011-05-04
JIANGSU CHANGLONG AGROCHEM CO LTD
View PDF2 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In these reports, liquid acid catalysts such as p-toluenesulfonic acid, sulfuric acid and P 2 o 3 Cl 4 , these acids not only strongly corrode the equipment, resulting in large investment in factory equipment, but also the catalyst is not easy to recover, and the acid dissolved in the product needs to be washed with a large amount of water, causing environmental problems

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Production method of benzofuranone
  • Production method of benzofuranone

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Put 200 g o-hydroxyphenylacetic acid, 500 mL toluene and 2 g D001 macroporous strongly acidic cation exchange resin (produced by Shanghai Huizhi Resin Factory) into a 1000 mL reaction bottle, start stirring, heat to reflux, and separate the generated water in the water separator. After about 6 hours, when the content of o-hydroxyphenylacetic acid is lower than 1%, it is cooled, centrifugally filtered, and the filtered resin is reused. Toluene was removed from the filtrate to obtain 179 g of benzofuranone with a content of 96.5% and a yield of 98.0%.

Embodiment 2

[0022] Put 200 g of o-hydroxyphenylacetic acid, 500 mL of cyclohexane and 10 g of 001*7 (732) strongly acidic cation exchange resin (produced by Shanghai Huizhi Resin Factory) into a 1000 mL reaction bottle, start stirring, heat to reflux, and The resulting water is separated. When the content of o-hydroxyphenylacetic acid is lower than 1%, it is cooled, centrifugally filtered, and the filtered resin is reused. Toluene was removed from the filtrate to obtain 178 g of benzofuranone with a content of 96.5% and a yield of 97.4%.

Embodiment 3

[0024] Put 200 g of o-hydroxyphenylacetic acid, 500 mL of chlorobenzene and 2 g of 00X7 (732) cation exchange resin (Changzhou Tehua Trading Co., Ltd.) into a 1000 mL reaction bottle, start stirring, heat to reflux, and separate the generated in the water separator water. When the content of o-hydroxyphenylacetic acid is lower than 1%, it is cooled, centrifugally filtered, and the filtered resin is reused. Toluene was removed from the filtrate to obtain 177 g of benzofuranone with a content of 97% and a yield of 97.4%.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a production method of benzofuranone, which is characterized in that o-Hydroxyphenylacetic acid is subject to azeotropic dehydration with a solvent only in the presence of commercial catalyst of cationic resins to generate benzofuranone, wherein the reaction temperature is 60-150 DEG C; the dosage of the catalyst is 0.1-20%; and the solvent accounts for 5-80% of the o-Hydroxyphenylacetic acid. The reacted solvent is no need of special treatment, and the filtered solvent is dehydrated to obtain the benzofuranone with concentration being above 96% in high yield.

Description

technical field [0001] The invention relates to a production method of benzofuranone. Benzofuranone is an important raw material for producing the fungicide azoxystrobin and belongs to the technical field of chemical manufacturing. Background technique [0002] Azoxystrobin is the first methoxyacrylate fungicide discovered and commercialized by Zeneca. Its mechanism of action is to inhibit mitochondrial respiration by blocking electron transfer between cytochromes. Because of its high-efficiency and broad-spectrum characteristics, it can prevent and control almost all fungal diseases (Oomycetes, Phycomycetes, Ascomycetes and Deuteromycetes). Germination and mycelial growth. It can be used for stem and leaf treatment, seed treatment, and soil treatment. [0003] Benzofuranone is an important intermediate for the preparation of azoxystrobin, and a lot of research has been done on its preparation method. Wherein the manufacture method with o-hydroxyphenylacetic acid as the...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07D307/83
Inventor 陆明若田庆海张中泽刘飞刘梅闻金
Owner JIANGSU CHANGLONG AGROCHEM CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com