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Gatifloxacin dispersible tablets and preparation method thereof

A technology for gatifloxacin and dispersible tablets, applied in the field of gatifloxacin dispersible tablets and their preparation, can solve the problems of large volume and troublesome gatifloxacin tablets, and achieve good fluidity, compressibility, and disintegration. good effect

Inactive Publication Date: 2011-05-11
华北制药集团制剂有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the large size of the existing gatifloxacin tablets, it is often necessary to take multiple tablets at a time, which is especially troublesome for the elderly, young and patients who have difficulty swallowing solids

Method used

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  • Gatifloxacin dispersible tablets and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] (a) Weigh raw materials and auxiliary materials according to the following weight ratios:

[0020] 200g of gatifloxacin, 40g of crospovidone, 140g of microcrystalline cellulose, 30g of hydroxypropyl cellulose, 7g of stevioside, 4.5g of magnesium stearate, an appropriate amount of 4% povidone K30 ethanol solution;

[0021] (b) Get the gatifloxacin, hydroxypropyl cellulose, microcrystalline cellulose, stevioside and crospovidone of the above-mentioned weight portion ratio, pass through 80 mesh sieves respectively, and cross 60 mesh sieves to mix evenly, Use 4% povidone K30 ethanol solution to make soft material, pass through a 30 mesh sieve to granulate, blow dry at 55°C, and then pass the dry granules through a 24 mesh sieve for granulation, then add the prescribed amount of crospovidone and hard Magnesium fatty acid is mixed and compressed into tablets to make dispersible tablets containing 200 mg gatifloxacin in each tablet.

Embodiment 2～6

[0023] (a) Weigh raw materials and auxiliary materials according to the following weight ratios:

[0024] Gatifloxacin 200g, stevioside 7g, magnesium stearate 4.5g, 4% povidone K30 ethanol solution in an appropriate amount; the disintegrants are shown in Table 1.

[0025] (b) Pass gatifloxacin, hydroxypropyl cellulose, microcrystalline cellulose, stevioside and crospovidone respectively through a 80-mesh sieve, then pass through a 60-mesh sieve, mix evenly, and use 4% povidone Ketone K30 ethanol solution is made into soft material, passed through a 30-mesh sieve to granulate, and air-dried at 60°C. The dried granules are then passed through a 24-mesh sieve for sizing, and then the prescribed amount of crospovidone and magnesium stearate are added. After mixing, compress into tablets to make dispersible tablets containing 400 mg of gatifloxacin in each tablet.

[0026] Table 1 The selection of disintegrants in different embodiments (mg)

[0027]

[0028] (c) Get the gatifl...

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Abstract

The invention discloses gatifloxacin dispersible tablets and a preparation method thereof. The dispersible tablets are prepared from the following raw materials and auxiliary materials in part by weight: 200 to 260 parts of gatifloxacin, 40 to 50 parts of crospovidone, 140 to 180 parts of microcrystalline cellulose, 30 to 40 parts of hydroxy propyl cellulose, 7 to 10 parts of stevia, 4.5 to 8 parts of magnesium stearate, and a proper amount of ethanol solution of povidoneK30; and the preparation method comprises the following steps of: taking the gatifloxacin, the microcrystalline cellulose, the hydroxy propyl cellulose, the stevia and the crospovidone according to the weight part ratio, respectively sieving by using a 80-mesh sieve, sieving by using a 60-mesh sieve, uniformly mixing, and preparing into a soft material by using the 4 percent ethanol solution of povidoneK30; sieving by using a 30-mesh sieve for granulation, performing forced air drying at the temperature of between 55 and 60 DEG C, and finishing the dry granules by using a 24-mesh sieve; and adding the crospovidone and the magnesium stearate according to the prescription, mixing, and tabletting. The tablets provided by the invention have good disintegration effect; and the granules prepared by the method have high fluidity and compressibility.

Description

technical field [0001] The invention relates to a preparation method of medicines and pharmaceutical preparations, in particular to gatifloxacin dispersible tablets and a preparation method thereof. Background technique [0002] Gatifloxacin is a new fluoroquinolone antibacterial drug listed in the late 1990s. It is another fluoroquinolone antibacterial drug developed by Kyorin Pharmaceutical Co., Ltd. of Japan. The introduction of 3-methylpiperazinyl at the 7-position enhances the antibacterial activity against Gram-positive bacteria, and also has antibacterial effects against anaerobic bacteria and mycoplasma. Certain activity, the introduction of the 8-methoxy group reduces the phototoxicity. The drug has a wide antibacterial spectrum and strong antibacterial activity. It not only maintains the good antibacterial activity of ciprofloxacin and other third-generation quinolones against Gram-negative bacteria, but also enhances the antibacterial activity against Gram-positi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/496A61K47/38A61P31/04
Inventor 路玉锋王志良刘书睿
Owner 华北制药集团制剂有限公司
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