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Method for improving fatty oil Chinese medicinal extract condensation efficiency and increasing concentration of concentrated solution

A technology for extracting liquid and concentrated liquid, which is used in pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc. and other problems, to achieve the effect of increasing specific gravity and concentration, shortening concentration time, and reducing the amount of adhesion

Active Publication Date: 2011-05-25
JIANGYIN TIANJIANG PHARMA
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AI Technical Summary

Problems solved by technology

[0003] However, due to the wide variety of traditional Chinese medicines, the properties of Chinese medicine extracts are quite different, especially in the preparation process of traditional Chinese medicine formula granules, single-flavored Chinese medicine decoction pieces are used as raw materials for extraction, so the property differences of Chinese medicine extracts are more significant. Traditional Chinese medicine varieties may have the problem of low concentration efficiency and inability to proceed smoothly
Especially for seeds, fruits, rhizomes and other traditional Chinese medicine varieties containing more fatty oil, due to the evaporation of water during the concentration process, the concentration and viscosity of the medicine solution increase significantly, so that the medicine solution is easy to adhere to the wall of the tube heater. Increase the thermal resistance, affect the evaporation, cause the specific gravity of the concentrated liquid to increase to a certain extent, it is difficult to continue to increase, and the concentration efficiency is low
The low specific gravity of the concentrated solution will affect the properties of the subsequent spray-dried extract powder, that is, the obtained extract powder has a small particle size, a small bulk density, and a low powder collection rate. Slow feeding, low processing speed and low granulation efficiency

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Take 2000Kg of fried Suanzaoren extract (solid content 3%), add 1.2Kg of sucrose monofatty acid lipid, dissolve evenly, and place in a concentration tank for concentration. The specific gravity of the concentrated solution has increased by 8%, the concentration time has been shortened by 33%, the yield of solids in the concentrated solution has increased by 30%, and the bulk density of the extract powder after spray drying has increased by 25%.

Embodiment 2

[0024] Take 2000Kg of cypress kernel extract (solid content 3%), add polysorbate 20 or 0.6Kg of hydroxylated phospholipid, dissolve evenly, and place it in a concentration tank for concentration. The specific gravity of the concentrated solution is increased by 5%, the concentration time is shortened by 20%, the yield of solids in the concentrated solution is increased by 25%, and the bulk density of the extract powder after spray drying is increased by 20%.

Embodiment 3

[0026] Take 2000Kg of Trichosanthes alba seed extract (solid content 3%), add polysorbate 80 and sorbitan fatty acid ester 60 mixed emulsifier (wherein the mass percentage of polysorbate 80 in the mixed emulsifier is 70%) 2.4g , after dissolving evenly, place it in the concentrated solution for concentration, the specific gravity of the concentrated solution increases by 10%, the concentration time shortens by 30%, the yield of solids in the concentrated solution increases by 20%, and the bulk density of the extract powder increases after spray drying 30%.

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Abstract

The invention relates to a method for improving fatty oil Chinese medicinal extract condensation efficiency and increasing the concentration of concentrated solution, which belongs to the technical field of Chinese medicine preparations. The method comprises the following steps of: adding an emulsifier in an amount which is 0.1 to 3 weight percent of the solid content of Chinese medicinal extract to be concentrated into the Chinese medicinal extract to be concentrated, and performing concentration, wherein the emulsifier has a lipophile balance value of 8 to 18, comprises a single polysorbate, hydroxylated lecithin or sucrose fatty acid ester emulsifier, and further comprises a mixed emulsifier consisting of hydroxylated lecithin or sucrose fatty acid ester and glyceryl monostearate, and the mixed emulsifier consisting of the polysorbate and dehydrated sorbitan fatty acid ester. The method can shorten the condensation time, improve the condensation efficiency, and increase the utilization rate of medicinal materials and the proportion and concentration of the concentrated solution, and is favorable for increasing the powder collection rate of spray drying and improving the dry granulation efficiency.

Description

technical field [0001] The invention relates to a method for concentrating a traditional Chinese medicine extract. It belongs to the technical field of traditional Chinese medicine preparations. Background technique [0002] Concentration of traditional Chinese medicine is one of the important unit operations in the production process of traditional Chinese medicine. It is to use appropriate technology and method to vaporize or separate and remove part of the solvent in the solution to increase the concentration of the solution or make the solution saturated to precipitate the solute. process. The use of thin film evaporation to concentrate traditional Chinese medicine extracts is widely used in the concentration of dilute solutions in the pharmaceutical industry. This method of concentration is to make the liquid form a thin film when it evaporates to increase the vaporization surface for evaporation. It is characterized by fast concentration of the leachate and short heat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/00A61K47/14A61K47/24A61K47/26A61K47/34A61K125/00A61K131/00
Inventor 陈盛君过科家周嘉琳王元清
Owner JIANGYIN TIANJIANG PHARMA
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