Opiates painkiller and opiate receptor antagonist-containing medicinal composition

An opioid receptor and composition technology, which is applied in the field of pharmaceutical compositions containing opioid analgesics and opioid receptor antagonists and the field of preparation thereof, can solve the problems of no improvement in analgesic activity of analgesics, and reduce adverse reactions. , enhance the effect of analgesic effect
CN102068697AActive Publication Date: 2011-05-25YICHANG HUMANWELL PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
YICHANG HUMANWELL PHARMA
Publication Date
2011-05-25

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Abstract

The invention provides an opiates painkiller and opiate receptor antagonist-containing medicinal composition. In the medicinal composition, an opiates painkiller is fentanyl, remifentanil, sufentanil, alfentanil and pharmaceutically acceptable salts thereof; and an opiate receptor antagonist is naloxone, naltrexone, nalmefene and pharmaceutically acceptable salts thereof. The medicinal composition has a pharmacological effect on analgesia. Compared with using the opiates painkiller singly, the composition can prevent and / or lighten side effects in pain treatment, reduce abuse and improve adaptability, and has a reinforcing effect on an analgesic effect of the opiates painkiller.
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Description

technical field

[0001] The invention relates to the technical field of medicine, and more specifically relates to a pharmaceutical composition containing an opioid analgesic and an opioid receptor antagonist, a preparation method and application thereof. Background technique

[0002] Opioid analgesics play an important role in pain management, and fentanyl, remifentanil, sufentanil, and alfentanil are commonly used opioid analgesics. However, after long-term intake, patients suffering from pain must take higher and higher doses to relieve pain, which is prone to drug dependence and addiction.

[0003] An opioid receptor antagonist refers to a substance that binds to an opioid receptor with high affinity, but does not cause a decrease in pain reception, and thus counteracts the action of an opioid agonist. Commonly used are naloxone, naltrexone, and nalmefene.

[0004] There has long been a need for a method that can both enhance the analgesic (suppressive) effects of opioi...

Claims

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