Method for separating ginkgolide B from ginkgolide mixture

A technology of ginkgolides and mixtures, applied in the field of chemical engineering, can solve the problems of large equipment investment, high equipment requirements, and large solvent consumption, and achieve the effects of less consumption, low cost, and less environmental pollution

Inactive Publication Date: 2011-05-25
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Compared with column chromatography, this method has a higher yield, and the simulated moving bed process is a continuous process, but this method has higher requirements for equipment

Method used

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  • Method for separating ginkgolide B from ginkgolide mixture

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Example Embodiment

[0041] Example 1

[0042] The commercially available ginkgolide mixture (wherein the weight percentages of ginkgolide A, ginkgolide B, ginkgolide C are respectively 60%, 26% and 10%) and ethyl acetate are made into a raw material solution of 20 g / L , with N-ethylpyridinium bromide ([EPy]Br)-water mixed solvent as extractant ([EPy]Br weight fraction is 70%), with ethyl acetate as detergent, extractant, detergent, raw material liquid The flow ratio of the three is 3:2.7:1, and the fractional extraction is carried out in the fractional extraction device at 40°C. The fractional extraction is divided into an extraction section and a washing section. The extractant enters the fractional extraction system from the first stage of the extraction section. The last stage of the extraction section enters the fractionation extraction system, the detergent enters the fractionation extraction system from the first stage of the washing section, and the raw material liquid is combined in the l...

Example Embodiment

[0043] Example 2

[0044] The commercially available ginkgolide mixture (wherein the total weight percent of ginkgolide A, ginkgolide B, and ginkgolide C is 96%) and butyl acetate are made into a raw material solution of 0.5 g / liter, using 1-butyl acetate -3-Dimethylimidazolium tetrafluoroborate ionic liquid ([BMIm][BF 4 ]) is the extractant, and butyl acetate is used as the detergent, and the flow ratio of the extractant, the detergent, and the raw material liquid is 2: 4.2: 1, and the fractional extraction is carried out in the fractional extraction device at 20 ° C. The fractional extraction is divided into: In the extraction section and the washing section, the extractant enters the fractionation extraction system from the first stage of the extraction section, the raw material liquid enters the fractionation extraction system from the last stage of the extraction section, and the detergent enters the fractionation extraction system from the first stage of the washing sect...

Example Embodiment

[0045] Example 3

[0046] The Ginkgo biloba extract is subjected to the general steps of extraction, precipitation, solvent evaporation, etc., to separate and obtain ginkgolide A, ginkgolide B, and ginkgolide C. The total weight percentage of solids is 42%, and the obtained solids are combined with n-butyl alcohol. The alcohol was made into a 100 g / L raw material solution, and tributylammonium chloride ([HNBu 3 ]Cl)-water mixed solvent as extractant ([HNBu 3 ]Cl weight fraction is 95%) as extractant, with n-butanol as detergent, the flow ratio of extractant, detergent and raw material liquid is 13:1.7:1, and fractional distillation is carried out in the fractional distillation extraction device at 70°C Extraction, fractional extraction is divided into extraction section and washing section. The extractant enters the fractionation extraction system from the first stage of the extraction section, the raw material liquid enters the fractionation extraction system from the last s...

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Abstract

The invention discloses a method for separating ginkgolide B from a ginkgolide mixture. The method comprises the following steps: by using an ionic liquid or a binary mixed solvent composed of ionic liquid and water as the extracting agent, and efficiently separating ginkgolide B from a mixture, which contains ginkgolide A, ginkgolide B, ginkgolide C and other ginkgolide homologues, through a fractional extraction process. The method has the advantages that the method has high separation efficiency, low solvent consumption, high safety, environmental protection and the like and is suitable for industrial production, etc.

Description

technical field [0001] The invention relates to a method for separating ginkgolide B, which belongs to the technical field of chemical engineering, in particular to a method for separating ginkgolide B from a mixture of ginkgolides. Background technique [0002] Ginkgolide is a kind of main active ingredient in Ginkgo biloba. It is a strong platelet-activating factor (platelet-activating factor, PAF) receptor antagonist. , Antibacterial and anti-inflammatory, anti-tumor, anti-rejection in organ transplantation and other curative effects. Ginkgolide has a twelve-carbon skeleton structure and is divided into ginkgolide A (ginkgolide A, GA), ginkgolide B (ginkgolide B, GB), ginkgolide C (ginkgolide C, GC) according to different substituents. Ginkgolide M (ginkgolide M, GM) and ginkgolide J (ginkgolide J, GJ), in addition to bilobalide (bilobalide, BB). The activity of ginkgolides is closely related to the chemical structure, among which ginkgolide B has the strongest antagoni...

Claims

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Application Information

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IPC IPC(8): C07D493/22
Inventor 邢华斌曹义风杨启炜苏宝根杨亦文苏云张芮菡倪晓蕾任其龙
Owner ZHEJIANG UNIV
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