Preparation method of sodium alginate nanofiber

A technology of sodium alginate and nanofibers, applied in fiber treatment, spinning solution preparation, fiber chemical characteristics, etc., can solve the problem of lack of entanglement, achieve the effect of increasing the strength of the solution and controlling the diameter of the fiber

Inactive Publication Date: 2011-05-25
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Due to the hydrogen bonds in the molecule and the rigid molecular chain containing carboxylic acid groups, the molecular chain is stretched in its aque

Method used

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  • Preparation method of sodium alginate nanofiber
  • Preparation method of sodium alginate nanofiber
  • Preparation method of sodium alginate nanofiber

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] 1) preparation concentration is the aqueous solution of the ethanol of 40wt%, the aqueous solution of preparation 20wt% DMF;

[0021] 2) Disperse the sodium alginate SA powder into 40wt% ethanol solution, the SA concentration is 4wt%, stir until the SA is completely dissolved, let it stand until the bubbles escape;

[0022] 3) Add 0.1wt% CaCl to the above SA solution 2 Aqueous to CaCl 2 The content is 2wt% of SA, stir while adding dropwise, let it stand after the dropwise addition is completed, and wait for the bubbles to escape. At this time, the concentration of SA solution is 2.2wt%;

[0023] 4) Add 20wt% N,N-dimethylformamide aqueous solution to SA spinning solution, the mass ratio of N,N-dimethylformamide solution and ethanol solution is 0.5, add water to adjust the concentration of SA to be 1.5wt % as spinning solution;

[0024] 5) Add the prepared spinning solution with a concentration of 1.5wt% into the syringe, adjust the voltage to 25kV, the distance from t...

Embodiment 2

[0026] 1) preparation concentration is the aqueous solution of the ethanol of 40wt%, the aqueous solution of preparation 20wt% DMF;

[0027] 2) Disperse the sodium alginate SA powder into a 40wt% ethanol solution, the SA concentration is 6wt%, stir until the SA is completely dissolved, and let it stand until the bubbles escape;

[0028] 3) Add 0.1wt% CaCl to the above SA solution 2 Aqueous to CaCl 2 The content is 2wt% of SA, stir while adding dropwise, let it stand after the dropwise addition is completed, and wait for the bubbles to escape. At this time, the concentration of SA solution is 2.72wt%;

[0029] 4) Add 20wt% N,N-dimethylformamide aqueous solution to SA spinning solution, the mass ratio of N,N-dimethylformamide solution and ethanol solution is 0.5, add water to adjust the concentration of SA to be 2wt% as a spinning solution;

[0030] 5) Add the prepared spinning solution with a concentration of 2wt% into the syringe, adjust the voltage to 25kV, the distance fr...

Embodiment 3

[0032] 1) preparation concentration is the aqueous solution of the ethanol of 20wt%, the aqueous solution of preparation 10wt% DMF;

[0033] 2) Disperse the sodium alginate SA powder into a 20wt% ethanol solution, the SA concentration is 4wt%, stir until the SA is completely dissolved, and let it stand until the bubbles escape;

[0034] 3) Add 0.1wt% CaCl to the above SA solution 2 Aqueous to CaCl 2 The content is 2wt% of SA, stir while adding dropwise, let it stand after the dropwise addition is completed, and wait for the bubbles to escape. At this time, the concentration of SA solution is 2.2wt%;

[0035] 4) Add 10wt% N,N-dimethylformamide aqueous solution to SA spinning solution, the mass ratio of N,N-dimethylformamide solution and ethanol solution is 0.5, add water to adjust the concentration of SA to be 1.5wt % as spinning solution;

[0036]5) Add the prepared spinning solution with a concentration of 1.5wt% into the syringe, adjust the voltage to 25kV, the distance f...

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Abstract

The invention relates to a preparation method of a sodium alginate nanofiber, belonging to the field of natural biological polymer materials. The preparation method comprises the following steps: dispersing sodium alginate powder in an ethanol solution, and adding water to regulate the concentration to 4-6 wt%; dropwise adding a crosslinking agent while stirring, and then standing, wherein the content of the crosslinking agent is 1-3 wt% of the sodium alginate; after bubbles emerge, dropwise adding a N,N-dimethyl formamide water solution while stirring, and then standing, thereby obtaining a sodium alginate spinning solution the concentration of which is 0.5-2 wt% after the bubbles emerge; adding the spinning solution into an injector, regulating the voltage to 10-25kV, regulating the distance between a sprayer and a receiver to 5-25cm, and regulating the flow rate to 0.1-1 ml/h; and starting a spinning device. The invention aims at the complicated after-treatment processes of crosslinking, washing, drying and the like for obtaining a pure SA (sodium alginate) nanofiber at present. The method can be used for directly preparing a slightly-crosslinked SA nanofiber, and a solvent can sufficiently volatilize in the spinning process.

Description

technical field [0001] The invention belongs to the technical field of natural biopolymer materials, and relates to a preparation method of sodium alginate nanofiber membranes. Background technique [0002] Alginate (Sodium Alginate, SA) is a natural polymer present in brown algae, a natural polysaccharide extracted from brown algae or bacteria, and has good biocompatibility. Alginic acid is composed of two structural units of guluronic acid (denoted as G segment) and its stereoisomer mannuronic acid (denoted as M segment), which are formed in three ways (MM segment, GG segments and MG segments) are linked by α-1,4 glycosidic bonds to form an unbranched linear block copolymer. Because SA has good biocompatibility and non-toxicity, it has broad application prospects in drug release and tissue engineering. Alginic acid is easily combined with some divalent cations to form a gel. According to literature reports (Biomaterials 2000, 21, 1921; Macromolecules 2004, 37, 6153), wh...

Claims

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Application Information

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IPC IPC(8): D01F9/04D01F1/10D01D1/02D01D5/00
Inventor 马贵平聂俊方大为畅文凯
Owner BEIJING UNIV OF CHEM TECH
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