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Preparation of water-soluble crosslinked chitosan and application thereof

A cross-linked chitosan, water-soluble technology, applied in other chemical processes, flocculation/sedimentation water/sewage treatment, anti-toxic agents, etc., can solve the problems of chitosan's easy dissolution and loss, unfavorable recovery of heavy metal ions, etc.

Inactive Publication Date: 2011-06-01
GENERAL HOSPITAL OF THE SECOND ARTILLERY OF CHINESE PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, because chitosan is easy to dissolve and lose under acidic conditions, which is not conducive to repeated use and recovery of heavy metal ions, chemical cross-linking methods are often used to prepare chitosan adsorbents.

Method used

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  • Preparation of water-soluble crosslinked chitosan and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The preparation of embodiment 1 copper ion template glyoxal cross-linked chitosan resin

[0033] Weigh 10 g of chitosan and suspend in 75 ml of 10% CuSO 4 Stir in the middle for 2h, soak overnight, filter to remove the solution, wash with water until NaS 2 method (5gNaS 2 Dissolved in 20ml distilled water) No Cu can be detected 2+ After pressing dry, suspend it in 60ml of water, add 3.75ml of 50% glyoxal, stir at room temperature for 3h to make it cross-linked, filter off the liquid, and wash the solid with ethanol and ether once respectively. Then use 0.1mol / l hydrochloric acid solution to dissolve Cu 2+ Elution, then washed with water to neutral, eluent with NaS 2 Can not detect Cu 2+ After that, wash with ethanol and ether once respectively.

[0034] The synthesis of embodiment 2 glutaraldehyde cross-linked chitosan

[0035] Synthetic process is the same as embodiment 1, replaces glyoxal and CuSO with glutaraldehyde 4 The complexed chitosan was reacted to obt...

Embodiment 3

[0036] The hydrogenation of embodiment 3 cross-linked chitosan

[0037]Take 10g of cross-linked chitosan and add 150ml of 1% acetic acid solution, adjust the pH to 4 with 0.1mol / l NaOH solution, weigh 5g of NaBH 4 Dissolve in 50ml of water, slowly add to the acetic acid solution of cross-linked chitosan, bubbling, react for 3 hours after adding, adjust the pH to 10 with 0.1mol / l NaOH solution, filter and dry in the air.

Embodiment 4

[0038] Synthesis of embodiment 4 water-soluble cross-linked chitosan

[0039] Get 12g crosslinked chitosan and pack in 1L three-neck flask, add 200ml w(H 2 o 2 ) = 6% aqueous hydrogen peroxide solution, stirred and reacted in a water bath at 60°C for 1 h, filtered under reduced pressure while heating, added 3 times the volume of 95% ethanol to the filtrate, stood for 12 h and suction filtered to obtain a light yellow solid, washed with 20 ml of absolute ethanol, and dried 4.6 g of the product was obtained, and the molecular weight measured by the viscosity method was 1500-2500.

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Abstract

The invention relates to preparation of water-soluble crosslinked chitosan and application thereof. The preparation comprises the following steps of: with different metal ions as templates, obtaining crosslinked chitosan through dialdehyde molecules by adopting a molecular imprinting technology; and hydriding Schiff base through sodium borohydride, and oxidizing and hydrolyzing by utilizing hydrogen peroxide to obtain the water-soluble crosslinked chitosan. The water-soluble crosslinked chitosan can be used for specifically adsorbing metal ions and applied to enrichment of metals, purification of metals bringing pollution to environment, emission acceleration of metals harmful to the human body as well as the injury treatment and emission acceleration of radionuclide.

Description

technical field [0001] The invention relates to the preparation and application of water-soluble cross-linked chitosan. The water-soluble cross-linked chitosan of the present invention adopts molecular imprinting technology, uses different metal ions as templates, reacts with dialdehyde molecules to obtain cross-linked chitosan, and oxidizes and hydrolyzes the water-soluble chitosan with sodium borohydride to obtain water-soluble Sexually cross-linked chitosan. It can specifically adsorb metal ions and be used in the enrichment of metals, the purification of environmental pollution metals, the promotion of harmful metals in the human body, the treatment and promotion of radionuclide damage. Background technique [0002] Chitosan (Chitosan referred to as CTS) is the product of chitin deacetylation, the chemical name is (1,4)-2-amino-2-deoxy-β-D-glucose, is a kind of good biodegradability, biological Compatibility, bioactivity and physico-mechanical properties of natural pol...

Claims

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Application Information

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IPC IPC(8): C08B37/08C08J3/24C08J9/26C08K5/07B01J20/24B01J20/30C02F1/56A61K31/722A61P39/02
Inventor 姜合作刘丽宏刘河张晓菲雷宁
Owner GENERAL HOSPITAL OF THE SECOND ARTILLERY OF CHINESE PLA
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