Nano-emulsion pharmaceutical composition containing spring onion extract for oral mucosa administration and preparation method thereof

Abstract

The invention provides a nano-emulsion pharmaceutical composition containing spring onion extract for oral mucosa administration, which is prepared from the following components: 10-20wt% of oil, 30-80wt% of water, 1-5wt% of surfactant, 1-10wt% of cosurfactant, 1-15wt% of spring onion extract, 0-4wt% of penetration enhancer and 0-15wt% of gel matrix. The gel matrix is added into the nano-emulsionto obtain a nano-emulsion gel pharmaceutical composition capable of being gelatinized in situ. The pharmaceutical composition is absorbed by oral mucosa administration to enter a body for circulating, thus the effect taking speed is high. Because the in-situ gel technology is adopted, the nano-emulsion is gelatinized in situ at 37 DEG C after being sprayed in the oral cavity to quickly adhere to the surface of the oral mucosa, thereby avoiding the loss of liquid medicines, prolonging the absorption time of the medicines on the surface of the mucosa, and prolonging the duration time of the medical effect.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and relates to a nanoemulsion pharmaceutical preparation for oral mucosal administration, in particular to a shallot extract nanoemulsion pharmaceutical composition for oral mucosal administration with rapid onset of action and a preparation method thereof. Background technique [0002] Nano-preparation technology is a new type of preparation technology resulting from the intersection and fusion of nanotechnology and modern preparation technology. It can change the physical, chemical and biological properties of drugs such as bioadhesion, transdermal / mucosal / Blood-brain barrier function, sustained and controlled release characteristics, targeting, long-term circulation characteristics, etc. Nanoemulsion (nanoemulsion) is composed of oil phase, water phase, surfactant, transparent or translucent liquid drug delivery system with emulsion droplet size of 100-1000nm. The advantages in aspects su...

AI Technical Summary

Problems solved by technology

[0003] In the application number 200510019202.1, the publication number CN1907420A titled "a drug for the treatment of myocardial ischemic diseases and its preparation method", the cooperative unit found that the extract of shallot from Liliaceae Allium plant has the functions of dilating coronary arteries, resisting oxidative damage, improving microcirculation , reducing heart load and improving myocardial ischemia, etc. Pharmacodynamic studies have shown that the shallot extract using traditional Chinese medicine preparation technology is effective in controlling the symptoms of myocardial ischemia and has no adverse reactions and glaucoma contraindications, but compared with chemical drugs The onset of action is relatively slow, and it still cannot satisfy the symptom relief during acute attack

Using nanoemulsion technology, the development of shallot extract nanoemulsion for sublingual mucosal administration solves the problems of slow onset of action and poor compliance, and provides an opportunity for the development of quick-acting preparations of traditional Chinese medicine

Images