Gastrointestinal transit disorder diagnosis composition and use thereof

Abstract

The invention discloses a gastrointestinal transit disorder diagnosis composition. The composition which can disintegrate at fixed time and fixed position in the gastrointestinal tract consists of an inner body, an outer layer covering the inner body and a gastrointestinal transit disorder diagnosis probe material which is mixed in the inner body or/and the outer layer. According to the evaluation of information on the probe marker material-containing preparation, such as position in the gastrointestinal tract, retention and image characteristics after disintegration, after a receiver takes the composition orally, the composition can be used for the diagnosis, positioning and degree and property judgment of clinic gastrointestinal transit disorder, such as gastrointestinal obstruction caused by benign and malignant occupation, and the identification and diagnosis of gastrointestinal transit disorder, such as redundant colon and irritable bowel syndrome.

Description

Gastrointestinal transit disorder diagnostic composition and use thereof technical field The invention belongs to the field of diagnostic reagents, and in particular relates to the preparation and application of a gastrointestinal pulse disintegration tracer preparation for in vitro image diagnosis of gastrointestinal transit disorders. Background technique Gastrointestinal transit dysfunction such as inflammatory small bowel or colonic obstruction (including complete obstruction and incomplete obstruction), intestinal obstruction caused by intestinal malignancy, Crohn's disease, intestinal tuberculosis, intestinal stromal tumor mass, intestinal Polyps, colon length syndrome, intestinal structural variation after complex surgery, irritable bowel syndrome, etc., are clinically manifested as abdominal distension, abdominal pain, constipation, diarrhea, intestinal obstruction, etc., and it is often difficult to clarify their location, nature, and degree in time. In recent ye...

AI Technical Summary

Problems solved by technology

However, these examinations have the following defects: (1) X-ray plain films, abdominal CT, MRI, and barium meal of the digestive tract are often difficult to establish the lesion location in the nearly ten-meter-long and complicated and tortuous gastrointestinal tract, and the results are susceptible to gas, overlap, and artifacts. (2) Gastrointestinal angiography needs to receive X-ray radiation for many times, which is harmful to the human body and takes up the time of patients and examiners, which is inefficient; (3) Gastrointestinal barium meal examination needs to take about 100- A suspension made of about 500g of barium sulfate and more than 250mL of water can basically meet the needs of part of the digestive tract development, but the results are easily affected by overlapping, artifacts, etc.; (4) water-soluble contrast examination containing iodine It also needs to consume a large amount of contrast medium, and it is usually mainly used for upper gastrointestinal contrast, and the whole digestive tract can not be achieved through oral admini...

Images