Method for preparing high-purity 3-chlorine-1,2-propylene glycol aliphatic ester

Abstract

The invention relates to a method for preparing high-purity 3-chlorine-1,2-propylene glycol aliphatic ester. The method comprises the following steps: thoroughly mixing 3-chlorine-1,2-propylene glycol with fatty acid chloride solution and a catalyst, standing for 6-36 hours at room temperature, and then filtering, washing and drying reaction liquid; processing dried organic residues by using any one or more of gel permeation chromatography (GPC), solid-phase extraction (SPE), liquid chromatography and the like so as to prepare the high-purity 3-chlorine-1,2-propylene glycol aliphatic ester; and finally, detecting the purity of the 3-chlorine-1,2-propylene glycol aliphatic ester by using a gas chromatograph-mass spectrometer. In the invention, the preparation method is simple, process parameters are stable, the purity of the extracted 3-chlorine-1,2-propylene glycol aliphatic ester is high, and the 3-chlorine-1,2-propylene glycol aliphatic ester can be used as a standard reference product for detection and analysis and as a raw material for a toxicology evaluation test.

Description

technical field [0001] The invention relates to a preparation method of 3-chloro-1,2-propanediol fatty acid ester, in particular to a preparation method of high-purity 3-chloro-1,2-propanediol fatty acid ester as a standard or reference substance. Background technique [0002] 3-Chloro-1,2-propanediol fatty acid ester (3-MCPDFAE) is a new class of pollutants found in food, especially in refined vegetable oil. Its formation mechanism is unknown, and it is now suspected that it is in the presence of chloride ions , formed during the deodorization of fats and oils, its toxicity is unknown, but since it can be hydrolyzed to 3-chloro-1,2-propanediol (3-MCPD), the toxicity of 3-chloro-1,2-propanediol is now It has been established that it is a confirmed human carcinogen, has reproductive toxicity, neurotoxicity, and can cause kidney tumors. Therefore, 3-chloro-1,2-propanediol fatty acid esters are also concerned at home and abroad. However, there is no standard reference product...

AI Technical Summary

Problems solved by technology

[0002] 3-Chloro-1,2-propanediol fatty acid ester (3-MCPDFAE) is a new class of pollutants found in food, especially in refined vegetable oil. Its formation mechanism is unknown, and it is now suspected that it is in the presence of chloride ions , formed during the deodorization of grease, its toxicity is unknown, but because it can be hydrolyzed to 3-chloro-1,2-propanediol (3-MCPD), and the toxicity of 3-chloro-1,2-propanediol is now It has been established that it is a confirmed human carcinogen, reproductive toxicity, neurotoxicity, and can cause kidney tumors

But there is no standard reference product of high-purity 3-chloro-1,2-propanediol fatty acid ester in China