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Preparation technology of new integrative formulation of siwu decoction and production method thereof

A production method and an integrated technology, applied in drug combination, pill delivery, pharmaceutical formulation, etc., can solve problems that need further research, increase immune cell activity, etc.

Inactive Publication Date: 2011-06-22
SUZHOU ZHIWEITANG BIOLOGICAL TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Active ingredients such as rehmannia polysaccharides, angelica polysaccharides, ferulic acid, paeoniflorin, and ligustrazine, the material basis of Siwu Decoction, all exhibit immune regulation effects to varying degrees. The immunomodulatory effect of Siwu Decoction comes from these active ingredients, and it is not a simple superposition of effects. Its mechanism of action and molecular mechanism need to be further studied

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Prepare the following raw materials by the aforementioned method:

[0043] Extracts, nanoparticles, microcapsules, nanoparticles.

[0044] The composition of the raw materials used to make the active ingredients is——

[0045] 15 parts of rehmannia glutinosa, 15 parts of angelica, 10 parts of white peony, and 8 parts of Chuanxiong.

[0046] Its manufacturing process is as follows:

[0047] In the GMP10000 clean room, the extract, nanoparticles, microcapsules, and nanoparticles are mixed according to the ratio of 4:2:2:2, and the latest version of the "Chinese Pharmacopoeia" preparation part of the hard capsule standard is adopted, without adding excipients, antiseptic The preparation is filled with hard capsules by a full-automatic capsule filling machine to make hard capsules. Then carry out internal and external packaging such as counting, bottling, sealing, pasting labels, coding, and packing. Finally, according to the production batch uniform instant sterilizatio...

Embodiment 2

[0049] Prepare the following raw materials by the aforementioned method:

[0050] Water decoction concentrate, nanoliposome, nanoemulsion, microemulsion, nanosuspension.

[0051] The composition of the raw materials used to make the active ingredients is——

[0052] 15 parts of rehmannia glutinosa, 15 parts of angelica, 10 parts of white peony, and 8 parts of Chuanxiong.

[0053] Its manufacturing process is as follows:

[0054] In the GMP10000 clean room, the decoction concentrate, nanoliposome, nanoemulsion, microemulsion, and nanosuspension are mixed according to the ratio of 5:1:1:2:1, and the latest version of "Chinese Pharmacopoeia" is used. Part of the soft capsule standard, without adding auxiliary materials and preservatives, adopts a fully automatic soft capsule filling machine to sub-pack soft capsules to make soft capsules. Then carry out internal and external packaging such as counting, bottling, sealing, pasting labels, coding, and packing. Finally, according ...

Embodiment 3

[0056] Prepare the following raw materials by the aforementioned method:

[0057] Extract, solid lipid nanoparticles, nanoemulsion.

[0058] The composition of the raw materials used to make the active ingredients is——

[0059] 15 parts of rehmannia glutinosa, 15 parts of angelica, 10 parts of white peony, and 8 parts of Chuanxiong.

[0060] Its manufacturing process is as follows:

[0061] In the GMP10000 clean room, the extract, solid lipid nanoparticles, and nanoemulsions are mixed in a ratio of 4:3:3, and the latest version of the "Chinese Pharmacopoeia" preparation part of the film standard is adopted, and the film-forming material is polyvinyl alcohol. Made into a film. Cartoning, sealing, sticking labels, printing codes, packing and other internal and external packaging. Finally, according to the production batch uniform instant sterilization, and issue a sterilization report. The area of ​​each film is 2-40 square centimeters, the drug content is 1.2-5 grams, and ...

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PUM

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Abstract

The invention relates to the preparation technology of a new integrative formulation of siwu decoction and a production method thereof. The siwu decoction comprises the following raw materials in part by weight: 15 parts of rehmanniae vaporata, 15 parts of Chinese angelica, 10 parts of white paeony root and 8 parts of szechuan lovage rhizome. The production process comprises the following steps of: alcohol / water extracting, ultrasonic crushing extracting, microwave extracting, decocting and concentrating, supersonic spray drying, high-pressure emulsification homogenizing, nanometer grinding, nanometer particle preparation and the like. The preparation technology and the production method have the advantages of multi-synergetic effect, multi-targeting effect and the like of nanometer traditional Chinese medicines. By the large-scale industrial production, the production cost can be reduced substantially, the quality of products can be improved, and the targeting and slow controlled release properties of medicaments are high; and a prepared membrane agent also can be applied to the skin of human bodies for treatment by transdermal absorption.

Description

technical field [0001] The invention relates to a preparation technology of a new integrated dosage form of Siwu Decoction, and also relates to a preparation technology of a new integrated dosage form of Siwu Decoction and a production method thereof. Background technique [0002] The relevant laws and regulations on drug management in my country stipulate that changing dosage forms is managed as a new drug research. The backwardness of the level of preparations not only affects the efficacy of drugs, but also leads to low added value of drugs, which directly affects market competition and industrial economic benefits. This is why the number of products in my country's pharmaceutical industry ranks among the top in the world and the output value is only equivalent to one or two multinational pharmaceutical companies. One of the main reasons. The development level of new drugs and new dosage forms can reflect the economic and technical strength of a country's pharmaceutical i...

Claims

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Application Information

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IPC IPC(8): A61K36/804A61K9/02A61K9/08A61K9/10A61K9/12A61K9/14A61K9/16A61K9/20A61K9/22A61K9/48A61K9/70A61K9/00A61P7/02A61P7/06A61P15/00A61P37/02
Inventor 杨洪舒
Owner SUZHOU ZHIWEITANG BIOLOGICAL TECH