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Chinese globeflower flower extractive dry powder inhalant for treating respiratory tract infections and inflammations and preparation method thereof

A technology of nasturtium extract and dry powder inhalation, which is applied in the field of pharmacy, and can solve problems such as dry powder inhalation preparations of traditional Chinese medicine extracts that have not yet been found.

Inactive Publication Date: 2014-03-19
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there is no research on Chinese medicine extract dry powder inhalation preparation, so the development of a Chinese medicine extract dry powder inhalation preparation for the treatment of respiratory diseases has great clinical significance and application value

Method used

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  • Chinese globeflower flower extractive dry powder inhalant for treating respiratory tract infections and inflammations and preparation method thereof
  • Chinese globeflower flower extractive dry powder inhalant for treating respiratory tract infections and inflammations and preparation method thereof
  • Chinese globeflower flower extractive dry powder inhalant for treating respiratory tract infections and inflammations and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1: Preparation of nasturtium extract powder spray by adding sugar carrier method

[0032] 3.25g nasturtium extract, 0.5g HPMC, 1.25g lactose were dissolved in 50% ethanol, stirred overnight to make it into a clear solution. Turn on the spray dryer and adjust the spray drying parameters as follows: the drying temperature is 78°C, the circulation pump power is 100%, the feed rate is 25%, and the atomizing air flow rate is 500L·H -1 , The atomizing air pressure is 0.6MPa. The above solution is placed at the spray drying inlet for spray drying. After the drying process, the obtained micropowder was collected and transferred to a vacuum drying oven, and dried at 40° C. for 24 hours. Take dry micropowder, load in 3 # Available in HPMC capsules.

Embodiment 2

[0033] Example 2: Preparation of Trollus chinensis extract powder spray by adding sugar carrier method

[0034] 3.25g nasturtium extract, 1.75g ​​HPMC, were dissolved in 50% ethanol, stirred overnight to make it into a clear solution. Turn on the spray dryer and adjust the spray drying parameters as follows: the drying temperature is 78°C, the circulation pump power is 100%, the feed rate is 25%, and the atomizing air flow rate is 500L·H -1 , The atomizing air pressure is 0.6MPa. The above solution is placed at the spray drying inlet for spray drying. After the drying process, the obtained micropowder was collected and transferred to a vacuum drying oven, and dried at 40° C. for 24 hours. Take the commercial lactose monohydrate, grind it through a 200-mesh sieve, collect the obtained lactose powder, put it in a three-dimensional mixer with the above-mentioned dry powder, and mix it at 100r·min -1 Mixed for 30min, loaded at 3# Available in HPMC capsules.

Embodiment 3

[0035] Embodiment 3: Preparation of nasturtium extract powder mist without adding sugar carrier method

[0036] 3.25g nasturtium extract, 1.25g HPMC, 0.5g ammonium carbonate were dissolved in 50% ethanol, stirred overnight to make it into a clear solution. Turn on the spray dryer and adjust the spray drying parameters as follows: the drying temperature is 78°C, the circulation pump power is 100%, the feed rate is 25%, and the atomizing air flow rate is 500L·H -1 , The atomizing air pressure is 0.6MPa. The above solution is placed at the spray drying inlet for spray drying. After the drying process, the obtained micropowder was collected and transferred to a vacuum drying oven, and dried at 40° C. for 24 hours. Take dry powder, load in 3 # Available in HPMC capsules.

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Abstract

The invention discloses a Chinese globeflower flower extractive dry powder inhalant for treating respiratory tract infections and inflammations and a preparation method thereof. The dry powder inhalant comprises a Chinese globeflower flower extractive, high-polymer material chitosan (CS), hydroxy propyl methyl cellulose (HPMC), povidone (PVP), polyethylene glycol (PEG) and / or gelatin, ammonium carbonate as an inorganic hole-forming agent and a saccharide carrier. The dry powder inhalant is prepared by adopting the following steps of: preparing a medicament or mixture micro powder of the medicament and an excipient with a spray drying method, and then mixing the medicament or the mixture micro powder with the corresponding saccharide carrier, wherein the particle size of the micro powder is less than 100 micrometers, the size of a majority of particles is 1-20 micrometers, the evacuation rate of a capsule is greater than 90%, and when the deposition rate of an active position is determined by a two-stage glass collider, the second-stage deposition rate is greater than 15%, and a releasing time is continued for 2 hours, 12 hours or 24 hours. The dry powder inhalant is used for treating the respiratory tract infections and inflammations, can improve local medicament concentration and relative bioavailability as well as a treatment effect and the compliances of patients.

Description

technical field [0001] The invention belongs to the field of pharmacy, and in particular relates to a powder spray of nasturtium flower extract and a preparation method thereof. Background technique [0002] Trollius is the dried flower of Trollius chinensis Bunge, a plant in the family Ranunculaceae, and it has various aliases such as Trollius chinensis Bunge, Trollius chinensis Bunge, Trollius chinensis Bunge, Trollius chinensis Bunge. "Compendium of Materia Medica Supplements" states that it is "bitter in taste, cold in nature, and non-toxic", and can "cure mouth sores, swollen throat, feverish teeth, ear pain, eye pain, improve eyesight, and relieve miasma." There are 25 species of Trollaceae plants, distributed in the northern temperate zone and cold temperate alpine regions. There are more than 10 species in my country, distributed in the northeast, north, northwest, and southwest. They are collected when they bloom in summer, and their flowers are used for medicinal p...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/14A61K9/48A61K36/71A61K47/36A61K47/42A61K47/48A61P11/00
Inventor 崔京浩朱云峰曹青日刘江云
Owner SUZHOU UNIV
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