Use of combination of potassium and magnesium for preparing medicine for preventing or treating gout

A use, gout technology, applied in the field of prevention and treatment of gout, especially the acute attack of gout, can solve the problem that potassium and/or magnesium are not found to treat or prevent gout

Inactive Publication Date: 2011-08-10
李超群
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Potassium and / or magnesium have not been found to be effective drugs for the treatment or prevention of gout, although magnesium or potassium has been reported as a nutritional supplement or as a drug for the adjunctive treatment of some diseases such as cardiovascular disease

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Patient, Wang Mou, male, 38 years old. History of gout for 4 years. Abnormal liver function for 2 months. Right first metatarsophalangeal joint discomfort for 1 day. The patient experienced abnormal liver function two months ago, ALT 112U / L, AST134U / L, and the rest of the liver function tests were normal. Hepatitis virus serological examination (HBVm, HAV-IgM, HCV-Ab, HEV-IgM, IgG and HDV-Ab) were all negative. No obvious fatigue and nausea, vomiting and so on. B ultrasound suggested fatty liver. The hospital used "fatty liver" for treatment, and treated with "Shuipencao" and "Glycyrrhizin Tablets", but the liver function failed to return to normal, ALT 67U / L, AST 78U / L. One day ago, the right metatarsophalangeal joint was uncomfortable, and there was no redness and severe pain in the right metatarsophalangeal joint. No fever, no cough, sore throat, runny nose, etc. Serum uric acid was 495 μmol / L (normal reference range 150-420 μmol / L). The patient is generally ...

Embodiment 2

[0031] Patient, Li, male, 45 years old. Gout history of 8 years. Recurrent attacks, about 3 times a year. During the gout attack, the right second metatarsophalangeal joint was red, swollen and severe pain occurred. affect walking. Before the attack, there are prodromal symptoms such as discomfort in the affected joints. Symptoms can be relieved after using "colchicine" and "allopurinol". He denied rheumatic fever and connective tissue diseases such as rheumatoid arthritis. He denied a history of hypertension. He denied history of trauma and surgery. He denied family history of remains and infectious diseases. One day ago, there was discomfort in the second metatarsophalangeal joint on the right without obvious incentives. No right metatarsophalangeal joint redness and pain. Serum uric acid was 479 μmol / L (normal reference range 150-420 μmol / L). Diagnosis: gout (prodromal period). Take "Potassium Magnesium Aspartate Tablets (Pan Nanjin)", 1 tablet each time (contain...

Embodiment 3

[0033] Patient, Zhang, male, 50 years old. There is a history of gout for 10 years. Gout recurs, about twice a year, with prodromal symptoms of gout before the onset. One day ago, discomfort occurred in the left first metatarsophalangeal joint, which was diagnosed as a prodrome of gout. Serum uric acid was 502 μmol / L (normal reference range 150-420 μmol / L). The patient is worried, worried about the acute attack of gout, and takes "Potassium Magnesium Aspartate Tablets (Pan Nanjin)". After 2 days, the discomfort of the left metatarsophalangeal joint disappeared, and the "potassium magnesium aspartate tablet" was stopped after 1 week. There were no subsequent gout attacks. Two weeks later, serum uric acid was 520 μmol / L. After 2 months, the left first metatarsophalangeal joint was uncomfortable again, and the symptoms disappeared after using "potassium magnesium aspartate" for 1 day, and continued to use "potassium magnesium aspartate" for 2 weeks. Thereafter, there was no...

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PUM

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Abstract

The invention relates to use of combination of potassium and magnesium for preparing a medicine for preventing or treating gout, wherein the potassium and the magnesium are in pharmaceutically acceptable salt form. The scheme of the invention can efficiently prevent or treat the acute gout with little toxic and side effects; therefore, the invention provides a new selection for preventing or treating the gout.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the prevention and treatment of gout, especially the acute attack of gout. Background technique [0002] Gout is a joint inflammatory disease caused by the deposition of monosodium urate crystals in peripheral joints, especially distal joints. The clinical feature of the disease is hyperuricemia and recurrent gouty acute arthritis caused by it, which can be manifested as severe joint pain, redness, and tophi deposition. The disease can also involve the kidneys. Excessive excretion of urate from the kidneys can cause urinary stones, and further development of urinary stones can lead to renal insufficiency. [0003] The etiology and pathogenesis of gout are not fully understood. It is generally believed that gout is caused by long-term purine metabolism disorder and increased blood uric acid. In humans and some primates, uric acid is the end product of purine metabolism. [0004] Gout i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/06A61K33/10A61K33/14A61K33/42A61K31/185A61K31/19A61K31/191A61K31/192A61K31/194A61K31/195A61K31/198A61K31/20A61P19/06A61K33/00
Inventor 李超群
Owner 李超群
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