Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Method for removing divalent metal ion from antibiotic etimicin liquid medicine

A divalent metal ion, etimicin technology, applied in chemical instruments and methods, sugar derivatives, sugar derivatives, etc., can solve problems such as the removal of divalent metal ions that have not been reported, and achieve significant energy-saving effects. Small loss, the effect of eliminating pollution and harm

Active Publication Date: 2013-06-05
CHANGZHOU FANGYUAN PHARMA +1
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far, there has been no report on the application of nanofiltration separation technology to remove divalent metal ions in antibiotic liquids, let alone the use of membrane technology to remove Zn in antibiotic drug etimicin P1. 2+ or Co 2+ removal of

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for removing divalent metal ion from antibiotic etimicin liquid medicine
  • Method for removing divalent metal ion from antibiotic etimicin liquid medicine
  • Method for removing divalent metal ion from antibiotic etimicin liquid medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] The medicinal liquid A that separation of the present invention is used is to contain antibiotic etimicin P1 medicine 3.083% (mass concentration), Zn2+ or Co 2+ 1.170% (mass concentration) aqueous solution.

[0036] The operating conditions for nanofiltration purification, concentration and separation of the antibiotic etimicin P1 medicinal liquid are as follows: feed liquid temperature 5-40°C, feed pressure 0.5-1.2 MPa. The purification and concentration separation effects of etimicin P1 drug liquid nanofiltration process were characterized by purification factor (α) and concentration factor (β) respectively.

[0037] Nanofiltration purification factor (α) expression:

[0038] α = Y P 1 / Y M 2 + ...

Embodiment 2

[0049] The same amount of etimicin P1 drug solution A as in Example 1 was used, and the microfiltration membrane permeate B obtained by pretreatment of the microfiltration membrane with a membrane pore size of 0.01 μm was placed in the feed liquid box 2 . At a feed liquid temperature of 40°C and an operating pressure of 0.5 MPa, the liquid medicine B was pumped into the nanofiltration membrane module 4 to carry out the same nanofiltration membrane diafiltration operation as in Example 1 to obtain purified etimicin P1 liquid medicine C, Its purification factor is 31.283. Then, the medicinal liquid C stored in the material liquid tank 1 is concentrated and operated in the same manner as in Example 1 to obtain purified and concentrated medicinal liquid D. The mass fraction of etimicin P1 in the medicinal liquid reaches 7.091%. The liquid concentration factor is 2.307.

Embodiment 3

[0051] The 25l microfiltration membrane permeate B obtained by the method of embodiment 1 is sent into the feed liquid tank 2, and then in the feed liquid tank 2, 25l purified water is added, that is, the feed liquid used as the nanofiltration membrane percolation and that of embodiment 1 for subsequent use In comparison, the drug solution B was diluted 1-fold. At a feed liquid temperature of 25° C. and an operating pressure of 0.8 MPa, the same operation method as in Example 1 was adopted to successively perform the diafiltration and concentration operations of the nanofiltration membrane. At this time, the purification factor of etimicin P1 liquid medicine was 31.072, and the concentration factor was 2.287.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
pore sizeaaaaaaaaaa
pore sizeaaaaaaaaaa
Login to View More

Abstract

The invention discloses a method for removing divalent metal ions from antibiotic etimicin P1 liquid medicine, which comprises the following steps of: separating etimicin P1 liquid medicine by a microfiltration membrane for removing impurities, such as macromolecular substances, particles, and the like; carrying out nanofiltration membrane constant volume percolation on collected microfiltration membrane penetrating liquid to obtain nanofiltration intercept liquid removing divalent metal ions; and carrying out nanofiltration membrane concentration on the intercept liquid to finally obtain thepurified and concentrated etimicin P1 liquid medicine. Nanofiltration membrane separation, purification and concentration are integrated into a whole in the method disclosed by the invention, no phase change happens in the process, the method is carried out at normal temperature, impurities, such as divalent metal ions, and the like are efficiently removed, etimicin P1 medicaments have no loss, the purification factor is 30.767-31.283 and the concentration factor is 2.198-2.307. The method is simple and convenient to operate, is easy for carrying out combined operation with a conventional separation unit, is suitable for industrial scale production, and has obvious effects of energy saving and emission reduction.

Description

technical field [0001] The invention relates to the field of membrane separation pharmacy, relates to a nanofiltration separation technology, in particular to a nanofiltration separation technology for removing divalent metal ions (Zn 2+ 、Co 2+ )Methods. Background technique [0002] Etimicin P1, a synthetic antibiotic raw material drug, is a collective name for two antibiotic drugs, namely: 3,2',6'-tris(N-acetyl)gentamycin C 1 a and 3,2',6'-tri(N-acetyl) sisomicin, etimicin P1 is prone to degradation under high temperature, and acetic anhydride, acetate (or other anhydrides) need to be added during its synthesis , salt) and other catalysts are obtained by catalysis. The existing etimicin P1 synthesis mostly adds zinc acetate or cobalt acetate, and its typical synthetic route is as follows: [0003] [0004] (1) The formula is 3,2',6'-three (N-acetyl) gentamicin C 1 The typical synthetic route of a [0005] [0006] (2) formula is 3,2', the typical synthetic rout...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C07H15/224C07H1/06B01D61/14
CPCY02P20/10
Inventor 蔡邦肖夏仙兵封成军胡东辉
Owner CHANGZHOU FANGYUAN PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com