Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of mon-carbonyl curcumin compound-based visual PH fluorescent probe

A single carbonyl turmeric and fluorescent probe technology, applied in the field of detection, can solve problems such as mechanical wear, and achieve the effects of good selectivity, little fluorescence background interference, and good stability

Inactive Publication Date: 2011-08-17
GUANGDONG UNIV OF TECH
View PDF2 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The electrode method is not used in the pH measurement of the living body due to the existence of electrochemical interference, possible mechanical wear and other defects

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of mon-carbonyl curcumin compound-based visual PH fluorescent probe
  • Application of mon-carbonyl curcumin compound-based visual PH fluorescent probe
  • Application of mon-carbonyl curcumin compound-based visual PH fluorescent probe

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Put 0.01 mol of 4-hydroxy-3-methoxy-benzaldehyde and 0.005 mol of acetone in a round bottom flask, add 20 mL of saturated HCl in glacial acetic acid solution, and stir at room temperature (25-30 ℃) for 30 min Leave it for 2 days. After the reaction was complete, 20 mL of water was added to the reaction flask, and the precipitate was filtered to obtain a crude product, which was recrystallized with ethanol and dried in vacuo to obtain an orange-yellow powder. 1,5-Bis(4-hydroxy-3-methoxy)-1,4-pentadien-3-one Yield 98%. mp 99–100 °C. 1 H NMR (DMSO-d6, 300 MHz) δ (ppm): 9.60 (brs, 2H, –OH), 7.63 (d, J = 15.9 Hz, 2H, –CH=C–), 7.35 (s, 2H, ArH ), 7.18 (d, J = 8.1 Hz, 2H, ArH), 7.12 (d, J = 15.9 Hz, 2H, –C=CH–), 6.81 (d, J = 8.1 Hz, 2H, ArH), 3.84 ( s, 6H, –OCH 3 ). ESI–MS (m / z): 325[M-1] - . Anal. Calc. for C 19 h 18 o 5 : C 69.93, H 5.56. Found: C 69.79, H 5.67.

Embodiment 2

[0030] Put 0.01 mol of 4-hydroxy-3-methoxy-benzaldehyde and 0.005 mol of cyclopentanone in a round-bottomed flask, add 20 mL of saturated HCl in glacial acetic acid, and stir at room temperature (25-30 °C) for 30 Leave it for 2 days after min. After the reaction was complete, 20 mL of water was added to the reaction flask, and the precipitate was filtered to obtain a crude product, which was recrystallized with ethanol. 2,5-Bis(4-hydroxy-3-methoxybenzylidene)cyclopentanone Yield 94%. mp 212–214 °C. 1H NMR (DMSO-d6, 300 MHz) δ (ppm): 9.64 (brs, 2H, –OH), 7.34 (s, 2H, –CH=), 7.23 (s, 2H, aroma), 7.15 (d, J = 8.1 Hz, 2H, ArH), 6.87 (d, J = 8.1 Hz, 2H, ArH), 3.83 (s, 6H, –OCH 3 ), 3.06 (s, 4H, –H 2 C–CH 2 –). ESI–MS (m / z): 351[M-1] - . Anal. Calc. for C 21 h 2 0O 5 : C 71.58, H 5.72. Found: C 71.50, H 5.88.

Embodiment 3

[0032] Put 0.01 mol of 4-hydroxy-3-methoxy-benzaldehyde and 0.005 mol of cyclopentanone in a round-bottomed flask, add 20 mL of saturated HCl in glacial acetic acid, and stir at room temperature (25-30 °C) for 30 Leave it for 2 days after min. After the reaction was complete, 20 mL of water was added to the reaction flask, and the precipitate was filtered to obtain a crude product, which was recrystallized with ethanol. Yield 98%. mp 178–179 °C. 1 H NMR (DMSO-d6, 300 MHz) δ (ppm): 9.48 (brs, 2H, –OH), 7.53 (s, 2H, –CH=), 7.08 (s, 2H, ArH), 7.01 (d, J = 8.1 Hz, 2H, ArH), 6.82 (d, J = 8.1 Hz, 2H, ArH), 3.79 (s, 6H, –OCH 3 ), 2.87 (t, J = 6.7 Hz, 4H, –H 2 C–C–CH 2 –), 1.71 (q, J = 6.7 Hz, 2H, –C–CH 2 –C–). ESI–MS (m / z): 365[M-1] - . Anal. Calc. for C 22 h 22 o 5 : C72.12, H 6.05. Found: C 72.03.48, H 6.02.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses an application of a mon-carbonyl curcumin compound-based visual PH fluorescent probe. The visual PH fluorescent probe has a structure as shown in the formula I. The fluorescent characteristic of a series of mon-carbonyl curcumins is very high in the sensitivity to the PH detection, is very high in the selectivity to hydrogen ions, and is very small in the interference to the other metal ions. The probes have wide prospect as being used as an reagent for the PH detection; the groups represented by R1, R2, R3 and R4 in the formula I are respectively to be one of substituent groups such as OH, H, OCHO3, Br; X is one of CH2, CH2-O-CH2, CH2-S-CH2; and n=0-2.

Description

technical field [0001] The invention belongs to the technical field of detection, and in particular relates to the application of a monocarbonyl curcumin-based compound as a visualized pH fluorescent probe. Background technique [0002] The pH value is an important parameter in systems such as physiology, pharmacology, and environment. The progress or completion of chemical reactions, and many important physiological processes of cells and organelles are closely related to its changes. Therefore, the determination of pH value is of great significance. The existing pH testing methods mainly include spectroscopic method, electrode method and indicator method. The electrode method is not used in the pH measurement of the living body due to the existence of electrochemical interference, possible mechanical wear and other defects. Fluorescence spectroscopy is a detection method based on optical signals, which has the advantages of high sensitivity, high selectivity, fast reflex...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/06G01N21/64
Inventor 张焜徐学涛杜志云卢宇靖张瑞瑞方岩雄赵肃清黄宝华黄华容谭伟郑杰
Owner GUANGDONG UNIV OF TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com