Nutritional support of the immune system during anti-cancer treatment
An immune cell and immune-enhancing technology, applied in the directions of bacteria, antidote, and antitumor drugs used in food preparation, can solve the problems of adding immune nutrients and no description.
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Embodiment 1
[0168] Immunosuppressive mechanisms in tumor-bearing animals—impaired innate and adaptive immune responses
[0169] mouse . Inbred 8-week-old C57BL / 6 (H-2b) mice were used in the experiments. Inoculate 1×10 subcutaneously (s.c.) on the left abdomen of the mouse 6 Tumor cells were monitored every 2 days for tumor growth by caliper measurements. Six days after tumor inoculation, animals were treated with oxaliplatin or doxorubicin. Tumor growth was monitored every 2 days after chemotherapy treatment, and animals were sacrificed 2 weeks after tumor implantation. Some trials continued until 28 days after chemotherapy to better assess tumor growth.
[0170] Body weights were assessed every 2 days until sacrifice.
[0171] Blood samples were collected on days 2 and 4 after chemotherapy, on day 10 and at sacrifice (day 14 or 28). Necropsy was performed and tumor mass was assessed.
[0172] cancer cell line . Methylcholanthrene (MCA)-induced sarcoma cell lines expressing o...
Embodiment 2
[0191] Immunosuppressive mechanisms exist in tumor-bearing animals undergoing chemotherapy. The state of the innate and adaptive immune responses.
[0192] mouse . Inbred 8-week-old C57BL / 6 (H-2b) mice were used in the experiments. Animals were divided into 7 different diet groups. The control group received diet AIN93 (maintenance) for adult rodents. The diets tested were administered at doses appropriate for the animal model: (a) control diet supplemented with 1% (w / w) L-arginine, (b) 25% protein replaced with glutamine, (c) 1% (w / w) / w) L-citrulline, (d) 1 g / Kg body weight active hexose related compound, (e) 20 mg / day RNA nucleotides and (f) 25 mg / day lactoferrin. One week later, MCA-OVA 1×10 was inoculated subcutaneously (s.c.) on the left abdomen of the mice. 6 Tumor cells, tumor growth was monitored every 2 days by caliper measurement. Six days after tumor inoculation, animals were treated with oxaliplatin or doxorubicin. Tumor growth was monitored every 2 days ...
Embodiment 3
[0217] Presence of immunosuppressive mechanisms in tumor-bearing animals undergoing chemotherapy can be partially compensated by specifically designed immunonutrition
[0218] mouse . Eight-week-old C57BL / 6(H-2b) mice were used in the experiments. Tumor cells were inoculated subcutaneously (s.c.) on the left flank of mice, and tumor growth was monitored by caliper measurement every 2 days. Necropsy was performed within 10-20 days after tumor transplantation to assess tumor quality. Cytomas were assessed for frequency of undergoing apoptosis, mitosis, and progression through the cell cycle (Ki 67 immunohistochemical staining). Animals were treated with chemotherapeutic agents 10 days after tumor implantation. The experimental animals were injected intraperitoneally (i.p.) 4 times a week with the following drugs, alone or in combination: cyclophosphamide (cyclophosphamide monohydrate), 100 mg / kg; methotrexate, RNX-0396, 25 or 50 mg / kg; Adriamycin (doxorubicin hydrochloride...
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