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Compound and application thereof in preparation of anti-tumor pharmaceutical, food or cosmetic

An anti-tumor effect and compound technology, applied in the preparation of organic compounds, anti-tumor drugs, applications, etc., can solve the problems that have not been solved, the route of administration is limited, and achieve excellent anti-tumor effects

Inactive Publication Date: 2014-03-12
ARSOA HONSHA CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Antitumor agents, cancer inhibitors, and anticancer agents are generally agents that selectively act on tumor cells and are less toxic to normal cells. However, there are still many problems in use that have not been resolved, such as bone marrow suppression. The emergence of fatal side effects such as leukopenia, thrombocytopenia, and neutropenia, the appearance of side effects of digestive system disorders such as nausea and vomiting, the appearance of side effects such as hair loss, the emergence of drug resistance, and drugs that are difficult to administer orally so many that the route of administration is restricted, etc.

Method used

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  • Compound and application thereof in preparation of anti-tumor pharmaceutical, food or cosmetic
  • Compound and application thereof in preparation of anti-tumor pharmaceutical, food or cosmetic
  • Compound and application thereof in preparation of anti-tumor pharmaceutical, food or cosmetic

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0193] Embodiment 1. The making of tablet

[0194] Tablets (500 mg per tablet) were prepared using the novel compound A that was classified and isolated according to the method described in the above "1-1. Novel compound A (1) Classification and isolation of the novel compound A" with the following prescription.

[0195]

[0196] New compound A (0.2g), dry cornstarch (2g), talc (1.8g), and calcium stearate (0.2g) were added and mixed to lactose (95.8g). Next, using a single-punch tablet press, tablets were prepared according to a conventional method.

Embodiment 2

[0197] Embodiment 2. the making of hard capsule

[0198] Using the novel compound B that was classified and separated according to the method described in the above "1-2. Novel compound B, C (1) Classification and separation of the new compound B and C", hard capsules were produced with the following prescription (average per 1 capsule 360mg).

[0199]

[0200] Lactose (220 g) and cornstarch (110 g) were added and mixed to novel compound B (5 g), and an aqueous solution of hydroxypropylcellulose (25 g) was added thereto, followed by kneading. Next, pellets were prepared by a conventional method using an extrusion pelletizer. Hard capsules are prepared by filling the granules into gelatin hard capsules.

Embodiment 3

[0201] Embodiment 3. the making of soft capsule

[0202] Using the novel compound C that was classified and separated according to the method described in the above "1-2. Novel compound B, C (1) Classification and separation of novel compound B and C", soft capsules were prepared with the following prescription (average per 1 capsules 170mg).

[0203] Novel compound C 0.5mg

[0204] Soybean Oil 169.5mg

[0205] (preparation method)

[0206] The novel compound C (0.5 g) was added and mixed to soybean oil (169.5 g). Soft capsules were then produced by filling into soft capsules according to the usual method using a rotary-mode automatic molding machine.

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PUM

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Abstract

The invention provides a novel compound which is safe without side effect and has a good anti-tumor function, an anti-tumor agent which is safe without side effect and has a good anti-tumor function, and pharmaceuticals, food or cosmetics which are safe without side effect and have a good anti-tumor function. The invention provides a novel compound (A) expressed in the following formula (1), an anti-tumor agent having the novel compound (A), and pharmaceuticals, food or cosmetics which have the novel compound (A) and an anti-tumor function.

Description

technical field [0001] The present invention relates to novel compounds, antitumor agents, and medicines, foods or cosmetics having antitumor effects. Background technique [0002] Antitumor agents, cancer inhibitors, and anticancer agents are generally agents that selectively act on tumor cells and are less toxic to normal cells, but there are still many problems in use that have not been resolved, such as bone marrow suppression. The emergence of fatal side effects such as leukopenia, thrombocytopenia, and neutropenia, the appearance of side effects of digestive system disorders such as nausea and vomiting, and the appearance of side effects such as hair loss, the emergence of drug resistance, and drugs that are difficult to administer orally More so that the route of administration is limited. Therefore, it is desired to develop antitumor agents, cancer inhibitors, and anticancer agents that selectively act on tumor cells, have very little toxicity to normal cells, and h...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D311/08C07C69/738C07C67/56A61K31/335A61K31/231A61P35/00A61K8/49A61K8/37A23L1/29A23L33/00
Inventor 太田富久高野文英辰野贵则高桥知也清水崇之
Owner ARSOA HONSHA CORP
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