Method for preparing medicine encapsulating liposome

Abstract

The invention relates to a method for preparing a medicine encapsulating liposome, which comprises: preparing medicine solid dispersion; and uniformly dispersing the medicine solid dispersion and a liposome film-forming material in an organic solvent to prepare the medicine encapsulating liposome. When the method is used, a medicine can be uniformly encapsulated in the liposome, the medicine encapsulating rate is improved, and sudden release of the medicine encapsulating liposome is reduced. The liposome is suitable for encapsulating various medicines and can be used in a wide formulation range.

Description

【Technical field】

[0001] The invention belongs to the field of pharmaceutical preparations, and more specifically, the invention relates to a preparation method of drug-encapsulated liposomes. 【Background technique】

[0002] Liposomes are monolayer or multilayer microcapsules composed of ordered lipid bilayers. Liposome belongs to the colloidal system, has a cell-like structure, has a strong affinity with the cell membrane, and can increase the ability of the encapsulated drug to penetrate the cell membrane. Liposomes have good biocompatibility, can realize targeted delivery of drugs in vivo, and have many advantages such as prolonging drug action time, increasing drug stability in vivo and in vitro, reducing drug toxicity, and enhancing pharmacological effects.

[0003] There are many methods for preparing liposomes, such as film dispersion method, reverse phase evaporation method, freeze-drying method, injection method, ultrasonic dispersion method, etc. At present, lipo...