Preparation method of encapsulated drug lipid microparticles

Abstract

The invention relates to a method for preparing medicine-encapsulating lipoid particles, which comprises the following steps of: preparing medicinal solid dispersoid, and dispersing the medicinal solid dispersoid and a film-forming material of the lipoid particles in organic solvent uniformly to prepare the medicine-encapsulating lipoid particles, so that medicines are encapsulated in the lipoid particles uniformly, the envelop rate of the medicines is improved, and the burst effect of the medicine-encapsulating lipoid particles is reduced. The medicine-encapsulating lipoid particles are suitable for encapsulating various medicines, and are wide in range of applicable formulations.

Description

【Technical field】

[0001] The invention belongs to the field of pharmaceutical preparations, and more specifically, the invention relates to a preparation method of drug-encapsulated lipid microparticles. 【Background technique】

[0002] Lipid particles are derived from liposomes. Liposomes, also known as niosomes, refer to single-layer or multi-layer new drug carrier single-layer vesicles made of lipid materials such as non-ionic surfactants. Higher than liposomes, it can overcome the toxicity of liposomes caused by phospholipid oxidation, and thus become a promising new drug delivery system.

[0003] Liposomes are used to encapsulate drugs, which can reduce or reduce the impact of environmental factors on drugs, prolong the effective time of drugs in vivo, improve the effective bioavailability of drugs in vivo, and reduce the toxic and side effects of drugs, especially for Targeted therapy of biologically active macromolecular drugs and heat-labile drugs.

[0004] With th...