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Compound sulfaclozine sodium suspension and preparation method thereof

A technology of sulfachlorpyrazine sodium and suspension, which is applied in the directions of liquid delivery, pharmaceutical formulation, emulsion delivery, etc., can solve the problem of difficulty in uniform dispersion, inability to ensure uniform ratio of main drug and synergist, and inability to administer uniformly And other issues

Active Publication Date: 2012-08-29
CHINANIMAL NANJING VETERINARY DRUGS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The difference in water solubility of the two drugs will inevitably lead to the difficulty of uniform dispersion during use. Not only can the drug be administered uniformly in the animal group, but also the absorption rate of the drug by the animal body after administration is also inconsistent, and at the same time the main drug and synergy cannot be guaranteed. The uniform ratio of the agent
The commonly used clinical dosage form is sulfachlorpyrazine sodium soluble powder, but the traditional sulfachlorpyrazine sodium soluble powder still cannot solve this problem well. In practical application, the treatment effect is poor, the cost is high, and it is easy to cause accumulation poisoning
It is obviously a drug composition with good therapeutic effect, but it cannot play a good role due to the limitation of administration

Method used

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  • Compound sulfaclozine sodium suspension and preparation method thereof
  • Compound sulfaclozine sodium suspension and preparation method thereof
  • Compound sulfaclozine sodium suspension and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0144] Formula: sulfachlorpyrazine sodium 10g

[0145] Trimethoprim 2g

[0146] Tween-80 0.1g

[0147] Sodium Carboxymethyl Cellulose 1.0g

[0148] Mix 0.05g of ethyl ester and propyl ester in volume ratio 1:1

[0149] Propylene glycol 20ml

[0150] EDTA (ethylenediaminetetraacetic acid) 0.2g

[0151] Quantify to 100ml with purified water; wherein, the particle size of trimethoprim is ≤16μm.

[0152] Preparation Process:

[0153] a) The mixed solution of ethyl ester and propyl ester in a volume ratio of 1:1 is mixed with 10 ml of propylene glycol.

[0154] b) Take sodium carboxymethyl cellulose, add it to the solution prepared in step a), and infiltrate evenly;

[0155] c) After dissolving EDTA with an appropriate amount of water, add the remaining propylene glycol, add water to dilute to 70ml, and finally add sulfachlorpyrazine sodium, stir to dissolve;

[0156] d) adding the solution obtained in step b) to the solution obtained in step c), and adding Tween-80 at the ...

Embodiment 2

[0159] Formula: sulfachlorpyrazine sodium 10g

[0160] Trimethoprim 2g

[0161] Tween-80 0.1g

[0162] Sodium Carboxymethyl Cellulose 1.0g

[0163] Mix 0.05g of ethyl ester and propyl ester in volume ratio 1:1

[0164] Propylene glycol 20ml

[0165] EDTA (ethylenediaminetetraacetic acid) 0.2g

[0166] Quantify to 100ml with purified water; wherein, the particle size of trimethoprim is ≤16μm.

[0167] Preparation Process:

[0168] a) The mixed solution of ethyl ester and propyl ester in a volume ratio of 1:1 is mixed with 10 ml of propylene glycol.

[0169] b) Take sodium carboxymethyl cellulose, add it to the solution prepared in step a), and infiltrate evenly;

[0170] c) After dissolving EDTA with an appropriate amount of water, add the remaining propylene glycol, add a certain amount of water to dilute to 70ml, and finally add sulfachlorpyrazine sodium, stir to dissolve;

[0171] d) adding the solution obtained in step b) to the solution obtained in step c), and add...

Embodiment 3

[0174] Formula: sulfachlorpyrazine sodium 15g

[0175] Trimethoprim 3g

[0176] Tween-80 0.01g

[0177] Sodium carboxymethylcellulose 0.1g

[0178] Benzoic acid 0.05g

[0179] Ethanol 30ml

[0180] EDTA (ethylenediaminetetraacetic acid) 0.02g

[0181] Quantify to 100ml with purified water; wherein, the particle size of trimethoprim is ≤16μm.

[0182] Preparation Process:

[0183] a) Benzoic acid is mixed with 10 ml ethanol.

[0184] b) Take sodium carboxymethyl cellulose, add it to the solution prepared in step a), and infiltrate evenly;

[0185] c) After dissolving EDTA with an appropriate amount of water, add the remaining ethanol, then add a certain amount of water to dilute to 50ml, and finally add sulfachlorpyrazine sodium, stir to dissolve;

[0186] d) adding the solution obtained in step b) to the solution obtained in step c), and adding Tween-80 at the same time, stirring evenly until it is clear;

[0187] e) Add trimethoprim to the solution obtained in step d...

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Abstract

The invention discloses compound sulfaclozine sodium suspension and a preparation method thereof. The suspension comprises sulfaclozine sodium, synergist, tween-80, sodium carboxymethylcellulose, ethylene diamine tetraacetic acid, preservative and solubilizing agent. The preparation method comprises the following steps of: mixing the preservative and the solubilizing agent in an amount which is 1 / 3-2 / 3 volume, and adding the sodium carboxymethylcellulose; adding the rest solubilizing agent into the ethylene diamine tetraacetic acid, adding water for diluting, finally adding the sulfaclozine sodium, stirring and dissolving; and mixing the solution, and adding the tween-80 and the synergist to obtain the suspension. According to the suspension, the ultra-micro pulverized synergist is stablydispersed in the suspension, and scientific suspending agent, surfactant and metal complexing agent are selected, so that the medicaments of the formulation do not produce accumulated sediment after being stood for a long term, uniform distribution of the medicaments in the aqueous phase is ensured, and the medicaments can be synchronous absorbed in use, meet the concentration proportion requirements of disease treatment and fully play a role in treatment.

Description

technical field [0001] The invention belongs to the field of veterinary medicine, in particular to a veterinary compound sulfachlorpyrazine sodium suspension and a preparation method thereof. Background technique [0002] Sulfachloropyrazine sodium is a sulfonamide anticoccidial drug with the same mechanism of action as sulfaquinoxaline. It has been widely used in the production of coccidiosis treatment. Due to the long-term application of the drug, the coccidia have developed a certain resistance to sulfachlorpyrazine sodium. In the treatment application, the single-use effect is poor, so it is generally combined with the sulfa synergist ditrimethoprim or trimethoprim pyridine to use. The two kinds of drugs have been tested and verified through long-term clinical cooperation. When the ratio of sulfachlorpyrazine sodium and trimethoprim or trimethoprim is about 5:1, the effect is the best, which not only improves the effect of sulfachlorpyrazine sodium The anti-coccidial e...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/635A61K31/505A61K9/10A61P33/02
Inventor 马小平徐瑞华李新梅王柄璋
Owner CHINANIMAL NANJING VETERINARY DRUGS