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High-ventilated degradable medicine-carrying skin wound dressing as well as preparation method and device thereof

A technology for skin wounds and air permeability, which is applied in the field of highly air-permeable and degradable drug-loaded skin wound dressings and its preparation, to achieve the effects of avoiding pain, inhibiting bacterial growth, and fast antibacterial performance

Active Publication Date: 2011-10-12
PKU HKUST SHENZHEN HONGKONG INSTITUTION +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

"Hemcon" is a medical hemostatic material processed with chitosan, but this material is made into a bandage type, which can only be used for superficial wounds, and cannot be used for larger and deeper wounds

Method used

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  • High-ventilated degradable medicine-carrying skin wound dressing as well as preparation method and device thereof
  • High-ventilated degradable medicine-carrying skin wound dressing as well as preparation method and device thereof
  • High-ventilated degradable medicine-carrying skin wound dressing as well as preparation method and device thereof

Examples

Experimental program
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Effect test

Embodiment

[0023] The preparation of embodiment drug-loaded skin wound dressing

[0024] Specific process such as figure 1 Shown: First mix a certain amount of chitosan (0.5-1.2 grams), water (15-30 grams) and lactic acid (0.2-1 milliliters) at 40-60 O Stir at high speed with a magnetic stirrer in a constant temperature water bath for 4 hours, and the system is translucent golden yellow viscous; then put the colloidal solution into a watch glass, and put it in a low-temperature freezer (-78 O C) Freeze for 24 hours, and then use a freeze dryer to freeze-dry until fluffy and spongy, which is solid chitosan lactate.

[0025] Dissolve chitosan lactate with deionized water to make a 5-15% aqueous solution, add 1-5 grams of sodium hyaluronate solution, mix and stir; when the system appears uniform and transparent, add tert-butanol Appropriate amount (the concentration of tert-butanol is 3-15% of the whole system), and continue to stir; when the system appears uniform and transparent, add a...

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Abstract

The invention discloses a high-ventilated degradable medicine-carrying skin wound dressing as well as a preparation method and device thereof, and belongs to the technical field of medical new materials. The high-ventilated degradable medicine-carrying skin wound dressing comprises the following components in percentage by weight: 45-50% of chitosan lactate; 45-50% of sodium hyaluronate and 5-10%of antibiotic. In the porous bioactivity dressing provided by the invention, a composite material of the chitosan lactate and the sodium hyaluronate is utilized as a substrate, and the antibiotic is loaded on the substrate. The dressing based on a special refrigerating process has the advantages of vertical pore ducts, high ventilation property, high hydroscopicity and moisture retention, therebyincreasing the permeability of the wound surface; the redundant exudate can be immediately absorbed while the moisture on the surface of the wound cannot be excessively evaporated. The dressing has long-term and effective effect on treating the surface of the wound so as to avoid the pain of the patient caused by frequent dressing change.

Description

technical field [0001] The invention belongs to the technical field of new medical materials, and in particular relates to a highly air-permeable and degradable drug-loaded skin wound dressing and a preparation method and equipment thereof. Background technique [0002] Generally, there are the following requirements for wound dressings: (1) have a softness similar to that of human skin, and can maintain a certain shape and strength when wet; (2) can maintain a moist environment on the wound surface, and have better absorption of wound secretions. (3) The dressing is non-toxic, does not cause harmful reactions and irritations to the human body, and must be able to prevent bacteria from entering the wound surface to prevent secondary infection, and avoid wound contact with particles and toxic pollutants , no heat source; (4) It is best to have hemostatic and pain-relieving effects, which can promote granulation growth and skin regeneration, accelerate healing, and reduce scar...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/42A61L15/44F25D3/10
Inventor 赖琛奚廷斐张志雄盛立远
Owner PKU HKUST SHENZHEN HONGKONG INSTITUTION
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