Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Supersaturated self-microemulsion as well as preparation method and application thereof

An emulsion preparation and a selected technology are applied in the field of supersaturated self-microemulsion preparations and their preparation, which can solve the problems of affecting clinical effect, low bioavailability, difficulty in indirubin and the like, and achieve simple preparation process, convenient administration and cost. low effect

Inactive Publication Date: 2011-11-02
SHANGHAI UNIV OF T C M
View PDF2 Cites 14 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] However, indirubin is insoluble in water, has low bioavailability for oral administration, poor absorption, and slow marked effect, which affects its clinical effect.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Supersaturated self-microemulsion as well as preparation method and application thereof
  • Supersaturated self-microemulsion as well as preparation method and application thereof
  • Supersaturated self-microemulsion as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] prescription composition

[0035] Indirubin: 15mg

[0036] Glyceryl monolinoleate (Maisine 35-1): 7.46g

[0037] Polyoxyethylene castor oil (Cremophor EL): 19.9g

[0038] Monoethyl ether oxalate (Transcutol P): 22.38g

[0039] Polyvinylpyrrolidone K17 (PVP K17): 0.245g

[0040] Make 100 indirubin supersaturated self-microemulsion soft capsules.

[0041] Preparation process: Weigh the oil phase glycerol monolinoleate of the prescription amount, the surfactant polyoxyethylene castor oil and the co-surfactant monoethyl ether oxalate and mix evenly, add the prescription amount of indirubin and the prescription amount of PVPK17 , Stir at 10°C to 25°C for 30 minutes to 3 hours, until the drug is completely dissolved, and then made into soft capsules.

Embodiment 2

[0043] prescription composition

[0044] Indirubin: 25mg

[0045] Glyceryl monolinoleate (Maisine 35-1): 10g

[0046] Polyoxyethylene castor oil (Cremophor EL): 18.48g

[0047] Monoethyl ether oxalate (Transcutol P): 20g

[0048] Hydroxypropylmethylcellulose (HPMC): 1.5g

[0049] Make 100 indirubin supersaturated self-microemulsion capsules.

[0050] Preparation process: Weigh the oil phase glycerol monolinoleate of the prescription amount, the surfactant polyoxyethylene castor oil and the co-surfactant monoethyl ether oxalate and mix evenly, add the prescription amount of indirubin and the prescription amount of HPMC , Stir at 10°C to 25°C for 30 minutes to 3 hours, until the drug is completely dissolved, and then made into capsules.

Embodiment 3

[0052] prescription composition

[0053] Indirubin: 5mg

[0054] Glyceryl monolinoleate (Maisine 35-1): 5g

[0055] Polyoxyethylene castor oil (Cremophor EL): 22.5g

[0056] Monoethyl ether oxalate (Transcutol P): 21.995g

[0057] Polyethylene glycol 4000 (PEG4000): 0.5g

[0058] Made indirubin supersaturated self-microemulsion oral liquid.

[0059] Preparation process: Weigh the oil phase glycerol monolinoleate in the prescription amount, the surfactant polyoxyethylene castor oil and the co-surfactant monoethyl ether oxalate and mix evenly, add the prescription amount of indirubin and the prescription amount of PEG4000 , Stir at 10°C to 25°C for 30 minutes to 3 hours, until the drug is completely dissolved, and then made into an oral liquid.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a supersaturated self-microemulsion, comprising Indirubin, an oil phase, a surfactant, a cosurfactant and a supersaturation accelerant. The invention further discloses a preparation method for the supersaturated self-microemulsion and an application of the supersaturated self-microemulsion in the preparation for a medicine treating tumour. The supersaturated self-microemulsion of the invention remarkably increases the bioavailability of Indirubin and has an important significance to enhance the anti-tumour effect of Indirubin.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a supersaturated self-microemulsion preparation and its preparation method and application. Background technique [0002] Self-microemulsion drug delivery system (SMEDDS) is a solid or liquid dosage form comprising an oil phase, a surfactant, and a co-surfactant, which is self-microemulsified into an oil-in-water (O / W) / W) type microemulsion with a particle size of less than 100nm, the microemulsion droplet has a large surface area, which increases the permeability of the drug in the epithelial cells of the gastrointestinal tract, thereby increasing the oral absorption and bioavailability of the drug, and enhancing the curative effect . [0003] However, when the conventional self-microemulsion drug delivery system is in contact with the gastrointestinal fluid, insoluble drugs tend to precipitate out after being released from the preparation, thereby reducing the dissolution an...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K31/404A61K47/34A61K47/38A61P35/00A61K47/10A61K47/14A61K47/44
Inventor 冯年平陈志强赵继会刘颖
Owner SHANGHAI UNIV OF T C M
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com