Preparation method for fritillaria cirrhosa fluid extract and fritillary and loquat particle

A technology of Chuan Fritillaria and liquid extract, which is applied in the field of preparation of traditional Chinese medicine preparations, and can solve the problems of concentration change, low recovery rate of active ingredients, easy loss of heat-sensitive ingredients, etc.

Active Publication Date: 2013-04-17
TAIJI GRP CHONGQING FULING PHARM FACTORY CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In the preparation method of the above-mentioned Chuanbei liquid extract and Chuanbei loquat granules, the active ingredients of Chuanbeimu are extracted by the percolation method, which has cumbersome process, long extraction time, easy volatilization loss of ethanol during the percolation process, resulting in concentration changes, active ingredients Problems such as low recovery rate
In the preparation method of Chuanbei loquat granules, the decoction method is also used to extract the active ingredients of other medicinal materials, which has the disadvantages of long extraction time, high extraction temperature, high energy consumption, easy loss of heat-sensitive ingredients, low recovery rate of active ingredients, troublesome post-processing, etc. shortcoming

Method used

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  • Preparation method for fritillaria cirrhosa fluid extract and fritillary and loquat particle

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Example 1. Preparation of Chuan Fritillaria Liquid Extract

[0045] a. Crush 4.5 kg of Fritillaria cirrhosa into coarse powder for use;

[0046] b. Add 60% ethanol equivalent to 7 times the weight of Fritillaria cirrhosa to the batching tank; switch the three-way valve to the batching tank position, turn on the agitator, diaphragm pump and diaphragm filter press of the batching tank, and reduce the 60% in the batching tank Ethanol is pumped into the diaphragm filter press (using 5-8 L / m 2 .s polypropylene multifilament filter cloth), until the press filtrate flows back into the batching tank, add the powder obtained in step a to the batching tank at a constant speed, after the addition, the membrane filter press cycle is extracted for 40 minutes, and then the three-way valve is switched to the filtrate storage Diaphragm pressure filtration is performed at the tank position to collect the pressure filtrate; after the pressure filtration is completed, the three-way valve i...

Embodiment 2

[0049] Example 2. Preparation of Chuan Fritillaria Liquid Extract

[0050] a. Crush 4.5 kg of Fritillaria cirrhosa into coarse powder for use;

[0051] b. Add 60% ethanol equivalent to 6 times the weight of Fritillaria cirrhosa to the batching tank; switch the three-way valve to the batching tank position, turn on the agitator, diaphragm pump and diaphragm filter press of the batching tank, and reduce 60% of the batching tank Ethanol is pumped into the diaphragm filter press (using 5-8 L / m 2 .s polypropylene multifilament filter cloth), when the press filtrate flows back into the batching tank, add the powder obtained in step a to the batching tank at a constant speed. After the addition, the membrane filter press cycle is extracted for 35 minutes, and then the three-way valve is switched to the filtrate storage Diaphragm pressure filtration is performed at the tank position to collect the pressure filtrate; after the pressure filtration is completed, the three-way valve is swi...

Embodiment 3

[0054] Example 3. Preparation of Chuan Fritillaria Liquid Extract

[0055] a. Crush 4.5 kg of Fritillaria cirrhosa into coarse powder for use;

[0056] b. Add 60% ethanol equivalent to 8 times the weight of Fritillaria cirrhosa to the batching tank; switch the three-way valve to the batching tank position, turn on the agitator, diaphragm pump and diaphragm filter press of the batching tank, and reduce the 60% in the batching tank Ethanol is pumped into the diaphragm filter press (using 5-8 L / m 2 .s polypropylene multifilament filter cloth), until the press filtrate flows back into the batching tank, add the powder obtained in step a to the batching tank at a constant speed, after the addition, the membrane filter press cycle is extracted for 30 minutes, and then the three-way valve is switched to the filtrate storage Diaphragm pressure filtration is performed at the tank position to collect the pressure filtrate; after the pressure filtration is completed, the three-way valve i...

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Abstract

The invention discloses a method for preparing Chuanbei fluid extract and Chuanbei loquat granules. The effective components of prescription medicinal materials are extracted by adopting the integrated technology of diaphragm press filtration, cycle extraction and separation, which can not only simplify the process flow, greatly shorten the production cycle, and save energy. Consumption is beneficial to environmental protection and waste residue utilization, and can reduce the amount of extraction solvent ethanol, and greatly improve the recovery rate of active ingredients.

Description

technical field [0001] The invention belongs to the field of pharmacy and relates to a preparation method of a traditional Chinese medicine preparation. Background technique [0002] Chinese Pharmacopoeia 2010 edition one Chuanbei loquat syrup preparation method records the preparation method of Chuanbeimu liquid extract as follows: take Chuanbeimu 45g, pulverize into coarse powder, use 70% ethanol as solvent, soak for 5 days, slowly Slow percolation, collect 38ml of the primary percolation liquid, store in another device, continue percolation, and when the soluble components are completely filtered out, the subsequent percolation liquid is concentrated to an appropriate amount, mixed with the primary percolation liquid, continued to concentrate to 45ml, and filtered to obtain . [0003] The State Food and Drug Administration Standard (Trial) WS-10357 (ZD-0357)-2002 records: Chuanbei Piquat Granules have the effects of clearing away heat and promoting lungs, reducing phlegm...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8966A61K9/06A61K9/16A61P11/00A61P11/14A61P11/10
Inventor 冯天炯胡黎明黄珠成顾维菊邓大用程地英蔡林凯魏素蓉涂卫红龚飞
Owner TAIJI GRP CHONGQING FULING PHARM FACTORY CO LTD
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