Dextromethorphan hydrobromide chewable tablet and preparation method thereof
A technology of dextromethorphan hydrobromide and film, applied in pill delivery, pharmaceutical formula, medical preparations containing active ingredients, etc.
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Embodiment 1
[0030] The weight composition ratio of each component contained in the prescription is:
[0031] Dextromethorphan hydrobromide 0.5 parts
[0032] 4.5 parts of beta cyclodextrin
[0033] Powdered gum base 90 parts
[0034] Mannitol 0.3 parts
[0035] 3 parts menthol
[0036] Aspartame 0.5 parts
[0037] Sweet orange essence 0.2 parts
[0038] Micronized silica gel 1 part
[0039] The preparation method comprises the following steps: Grinding dextromethorphan hydrobromide and cyclodextrin with an equal amount of water for 1 hour to form a paste, making an inclusion compound, drying in an oven at 55°C, grinding through a 100-mesh sieve, and then The clathrate powder was sieved and mixed with mannitol, aspartame, powdered sweet orange essence and menthol, added appropriate amount of water and passed through a 20-mesh granulation, dried in an oven at 55°C, passed through a 24-mesh sieve for granulation, and then mixed with powder glue Put the same amount into the mixer and m...
Embodiment 2
[0041] The weight composition ratio of each component contained in the prescription is:
[0042] 1.5 parts of dextromethorphan hydrobromide
[0043] Beta cyclodextrin 10 parts
[0044] Powdered gum base 93 parts
[0045] Mannitol 1 part
[0046] 3 parts menthol
[0047] 1 serving of aspartame
[0048] 1 part sweet orange essence
[0049] Micronized silica gel 1 part
[0050] The preparation method includes the following steps: Grinding dextromethorphan hydrobromide and cyclodextrin with double the amount of water for 1 hour by the research method to make a paste, making an inclusion compound, drying in an oven at 55°C, and grinding through 100 mesh Sieve, then put the clathrate powder with mannitol, aspartame, micronized silica gel, powdered sweet orange essence and menthol into the mixer and mix for at least 30 minutes, and then mix with the powdered gum base in equal amounts for at least 10 minutes , the powder is directly compressed into tablets using an ordinary tab...
Embodiment 3
[0052] 1 part dextromethorphan hydrobromide
[0053] 6 parts of hydroxypropyl beta cyclodextrin
[0054] Powdered gum base 80 parts
[0055] Lactose 0.5 parts
[0056] Mannitol 0.3 parts
[0057] 2 parts menthol
[0058] Stevioside 1 part
[0059] Essence 1 part
[0060] 2 parts magnesium stearate
[0061] The preparation method is basically the same as in Example 1.
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