Dextromethorphan hydrobromide chewable tablet and preparation method thereof

A technology of dextromethorphan hydrobromide and film, applied in pill delivery, pharmaceutical formula, medical preparations containing active ingredients, etc.

Active Publication Date: 2011-11-30
CHONGQING MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are very few domestic studies on chewing gum preparations, and only a few literatures mention

Method used

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  • Dextromethorphan hydrobromide chewable tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The weight composition ratio of each component contained in the prescription is:

[0031] Dextromethorphan hydrobromide 0.5 parts

[0032] 4.5 parts of beta cyclodextrin

[0033] Powdered gum base 90 parts

[0034] Mannitol 0.3 parts

[0035] 3 parts menthol

[0036] Aspartame 0.5 parts

[0037] Sweet orange essence 0.2 parts

[0038] Micronized silica gel 1 part

[0039] The preparation method comprises the following steps: Grinding dextromethorphan hydrobromide and cyclodextrin with an equal amount of water for 1 hour to form a paste, making an inclusion compound, drying in an oven at 55°C, grinding through a 100-mesh sieve, and then The clathrate powder was sieved and mixed with mannitol, aspartame, powdered sweet orange essence and menthol, added appropriate amount of water and passed through a 20-mesh granulation, dried in an oven at 55°C, passed through a 24-mesh sieve for granulation, and then mixed with powder glue Put the same amount into the mixer and m...

Embodiment 2

[0041] The weight composition ratio of each component contained in the prescription is:

[0042] 1.5 parts of dextromethorphan hydrobromide

[0043] Beta cyclodextrin 10 parts

[0044] Powdered gum base 93 parts

[0045] Mannitol 1 part

[0046] 3 parts menthol

[0047] 1 serving of aspartame

[0048] 1 part sweet orange essence

[0049] Micronized silica gel 1 part

[0050] The preparation method includes the following steps: Grinding dextromethorphan hydrobromide and cyclodextrin with double the amount of water for 1 hour by the research method to make a paste, making an inclusion compound, drying in an oven at 55°C, and grinding through 100 mesh Sieve, then put the clathrate powder with mannitol, aspartame, micronized silica gel, powdered sweet orange essence and menthol into the mixer and mix for at least 30 minutes, and then mix with the powdered gum base in equal amounts for at least 10 minutes , the powder is directly compressed into tablets using an ordinary tab...

Embodiment 3

[0052] 1 part dextromethorphan hydrobromide

[0053] 6 parts of hydroxypropyl beta cyclodextrin

[0054] Powdered gum base 80 parts

[0055] Lactose 0.5 parts

[0056] Mannitol 0.3 parts

[0057] 2 parts menthol

[0058] Stevioside 1 part

[0059] Essence 1 part

[0060] 2 parts magnesium stearate

[0061] The preparation method is basically the same as in Example 1.

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Abstract

The invention belongs to the technical field of medicinal preparations, and discloses dextromethorphan chewing gum tablets and an industrially applicable preparation method thereof. The preparation is delivered through a chewing process, so that the defects of the marketed products at present can be overcome, and the tablets have the advantages of no need of water for taking, convenience in taking, good mouthfeel, less adverse effects, quick response, capability of eliminating thirst and the like. The dextromethorphan chewing gum tablets prepared by the invention are mainly used for dry coughand are suitable for cold, acute or chronic bronchitis, bronchial asthma, faucitis, phthisis and cough during other upper respiratory tract infections. The dextromethorphan chewing gum tablets provided by the invention have the advantages of simple preparation process, low cost, easiness in control and easiness for industrial production.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and relates to an antitussive drug dextromethorphan hydrobromide chewable film tablet and a preparation method for industrial application thereof. Background technique [0002] Dextromethorphan (DH) is a synthetic central antitussive that acts by inhibiting the medullary cough center. Its antitussive strength is equal to or slightly stronger than codeine. It has no analgesic effect, no tolerance and addiction in long-term application, does not affect the healthy growth of children, and is especially suitable for children. Mainly used for dry cough, suitable for cold, acute or chronic bronchitis, bronchial asthma, pharyngitis, tuberculosis and other upper respiratory tract infections. Therapeutic dosage does not inhibit respiration, is well absorbed orally, takes effect within 15-30 minutes, and can last for 3-6 hours. DH on the domestic market is mainly tablets, capsules, granules an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/485A61K47/40A61P11/14
Inventor 张景勍刘娟赵春景
Owner CHONGQING MEDICAL UNIVERSITY
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