Papaverine rare earth chelate and its synthesis method and application

A technology of rare earth chelate and sea papaverine, applied in chemical instruments and methods, compounds containing elements of group 3/13 of the periodic table, medical preparations containing active ingredients, etc., to achieve strong anti-tumor activity and good medicine effect with value

Inactive Publication Date: 2011-11-30
GUANGXI NORMAL UNIV
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  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Rare earth elements have important strategic value and wide application prospects for our country. Among them, the application of rare earth elements in biological activity is unique. It has been proved by research that it has antibacterial, anti-inflammatory, and immune-enhancing effects. The rare earth-based medicinal chemistry based on papaverine oxide Research is currently blank

Method used

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  • Papaverine rare earth chelate and its synthesis method and application
  • Papaverine rare earth chelate and its synthesis method and application
  • Papaverine rare earth chelate and its synthesis method and application

Examples

Experimental program
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Effect test

Embodiment 1

[0028] Embodiment 1: Synthesize OGC-La with normal pressure solution method III Chelate

[0029] 1mmol La(NO 3 ) 3 .6H 2 O was dissolved in 5mL of methanol; 2mmol of OGC was heated and dissolved in 15mL of methanol. The two solutions were mixed and reacted at 70°C (reflux for condensation) for 1 hour. After the reaction, a red suspension was obtained with a large number of complexes. A solid was formed; the solution was filtered, and the filtered solid was washed with water, methanol, and ether in turn, and dried to finally obtain a red solid product. The product was determined to be the target chelate [La(OGC) 2 (NO 3 ) 3 ].

Embodiment 2

[0030] Embodiment 2: OGC-Ce is synthesized with normal pressure solution method III Chelate

[0031] 1mmol Ce(Ac) 3 .xH 2 O(Ac represents the acetate anion CH 3 COO - , the same below) was dissolved in 10mL of water; 2mmol of OGC was dissolved in 50mL of ethanol, and the two solutions were mixed and reacted at 80°C (reflux for condensation) for 6 hours. After the reaction, a red suspension was obtained, with a large amount of compound A solid was generated; the solution was filtered, and the filtered solid was washed with water, ethanol, and ether in turn, and dried to finally obtain a red solid product. The product was determined to be the target chelate [Ce(OGC) 2 (Ac) 3 ].

Embodiment 3

[0032] Embodiment 3: OGC-Nd is synthesized with normal pressure solution method III Chelate

[0033] 1 mmol Nd(Ac) 3 .xH 2 O was dissolved in 50mL of water; 2mmol of OGC was dissolved in 150mL of ethanol, and the two solutions were mixed and reacted at 80°C (reflux for condensation) for 24 hours. After the reaction, a red clear solution was obtained; most of them were removed by distillation under reduced pressure Solvent, a large amount of complex solids were precipitated, after cooling, the solution was filtered, and the filtered solids were washed with water, ethanol, and ether in turn, and dried to finally obtain a red solid product. The product was determined to be the target chelate [Nd(OGC) 2 (Ac) 3 ].

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Abstract

The invention discloses a rare earth chelate compound with oxidized glaucine as a ligand. The structural formula of the rare earth chelate compound is shown as a formula (I), wherein M represents one tervalent rare earth cation ion in a period table of elements, and L represents an anion of rare earth metal salt when the rare earth cation participates in reaction in a form of the metal salt, namely, L represents nitrate radical or acetate radical. The rare earth chelate compound with oxidized glaucine as a ligand is synthesized by using a normal pressure solution method or high pressure solvent thermal method. The invention also discloses an inhibition effect of the rare earth chelate compound on various tumor cell strains. Results indicate that multiple rare earth chelate compounds show stronger antitumor activities as compared with the oxidized glaucine ligand, thus the rare earth chelate compound disclosed by the invention has a good potential medicinal value and is hopefully used for preparation of various antitumor medicaments.

Description

technical field [0001] The invention relates to a metal chelate, in particular to a rare-earth chelate with sea papaverine oxide as an organic ligand, a synthesis method and application thereof. Background technique [0002] Oxidized aporphine alkaloids are a series of alkaloids with strong pharmacological activity. For example, michelin has strong antibacterial activity, oxycobanine has acetylcholinesterase inhibitory activity, and oxidized sea papaverine, Tulipine is an alkaloid with significant antitumor activity. It is generally believed that the conjugated polyaromatic ring structure and the methylenedioxy group (-O-CH 2 The presence of -O-) has a significant relationship with its antitumor activity. [0003] Oxoglaucine (OGC) is a typical oxidized aporphine, which is widely found in traditional Chinese medicine plants such as Magnoliaceae, Anemonaceae, Papaveraceae, and Fangjiceae. The current research on papaverine mainly includes three aspects: one is to find and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F5/00A61K31/555A61P35/00
Inventor 陈振锋梁宏刘延成史艳芳
Owner GUANGXI NORMAL UNIV
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