A kind of steam explosion pretreatment method of Ginkgo biloba

A technology of Ginkgo biloba leaves and pretreatment, which is applied in directions such as medical raw materials derived from Ginkgo biloba, can solve the problems of increased energy consumption, increased cost, and affected extraction efficiency processing process, etc., and achieves the effects of enhancing the degree of damage and improving the dissolution efficiency.

Inactive Publication Date: 2011-12-14
INST OF PROCESS ENG CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Therefore, no matter what extraction method is used, the degree of damage to plant cells will directly affect the extraction efficiency and subsequent processing.
[0004] Traditional methods generally use mechanical pulverization to crush materials, but because plant ce...

Method used

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  • A kind of steam explosion pretreatment method of Ginkgo biloba
  • A kind of steam explosion pretreatment method of Ginkgo biloba
  • A kind of steam explosion pretreatment method of Ginkgo biloba

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Add the solution according to the ratio of 1:1 of the quality of the dry ginkgo leaves and the acetic acid solution of pH4.0, and then soak for 30 minutes at room temperature; Put liquid nitrogen into the tank to make the temperature in the tank reach 180°C, maintain it for 5 minutes, and then carry out steam explosion treatment; then quickly release the pressure, release the material processed in the steam explosion tank into the normal pressure container, and obtain the material after gas explosion pretreatment. Grind the steam-exploded ginkgo leaves and the original untreated ginkgo leaves to 60 mesh with a plant pulverizer, add 70% ethanol solution at a liquid-solid ratio of 20:1 (mL / :g), heat and reflux in a water bath at 85°C for 2 hours, filter, The filtrate is reclaimed, the filter residue is repeatedly extracted 3 times as described above, the filtrate is combined, and the extraction rate of the total flavonoids of Ginkgo biloba is measured in the filtrate: 2....

Embodiment 2

[0026] Add distilled water according to the ratio of 1:2 of the quality of dry ginkgo leaves and distilled water, and then soak at normal temperature for 60 minutes; put the soaked material in the steam explosion tank, and feed ozone to make the temperature in the tank reach 150 ° C. After 30 minutes, the steam explosion treatment is carried out; then the pressure is quickly released, and the material processed in the steam explosion tank is released into the normal pressure container, and the material after the gas explosion pretreatment is obtained. Grind the steam-exploded ginkgo leaves and the original untreated ginkgo leaves to 60 mesh with a plant pulverizer, add 70% ethanol solution at a liquid-solid ratio of 20:1 (mL / :g), heat and reflux in a water bath at 85°C for 2 hours, filter, Reclaim filtrate, filter residue is repeatedly extracted 3 times by above-mentioned method, merges filtrate, measures the extraction rate of ginkgo total flavonoids in the filtrate: 2.18g t...

Embodiment 3

[0028] Add the solution according to the ratio of 1:3 of the quality of the dry ginkgo leaves and the sodium hydroxide solution of pH 10.0, and then soak at room temperature for 60 minutes; put the soaked material in the steam explosion tank, and feed nitrogen to make the tank The internal temperature reaches 200°C and is maintained for 1 minute before steam explosion treatment; then the pressure is quickly released, and the material treated in the steam explosion tank is released into the normal pressure container, and the material after gas explosion pretreatment is obtained. Grind the steam-exploded ginkgo leaves and the original untreated ginkgo leaves to 60 mesh with a plant pulverizer, add 70% ethanol solution at a liquid-solid ratio of 20:1 (mL / :g), heat and reflux in a water bath at 85°C for 2 hours, filter, Reclaim filtrate, filter residue is repeatedly extracted 3 times by above-mentioned method, merges filtrate, measures the extraction rate of ginkgo total flavonoi...

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Abstract

In order to eliminate the influence of compact structures of cell walls of ginkgo leaves on the dissolution of active ingredients and improve the dissolution efficiency of ginkgo leaf extract, the invention provides a steam explosion pretreatment method for the ginkgo leaves. The method comprises the following steps of: adding absolute dry ginkgo leaves into solution in a mass ratio of 1:0-1:4, and soaking at normal temperature for 5 to 180 minutes; putting the soaked materials into a steam explosion tank, introducing a steam explosion medium, raising the temperature in the tank to 30 to 250 DEG C, keeping the temperature for 1 to 30 minutes, and performing steam explosion; and releasing pressure quickly, and releasing the treated materials in the steam explosion tank to a constant-pressure container to obtain the materials which is subjected to steam explosion pretreatment. By the steam explosion pretreatment, structures of the ginkgo leaves are loosened to form obvious porous structures, and the dissolution efficiency of active ingredients is improved, but the active ingredients in the raw materials are not damaged; and the active ingredients of the ginkgo leaves which are subjected to the steam explosion can be extracted or crushed or subjected to superfine crushing directly to prepare various ginkgo products.

Description

technical field [0001] The invention belongs to the field of processing and application of traditional Chinese medicinal materials, in particular to a method for enhancing the dissolution of ginkgo active ingredients by steam explosion. Background technique [0002] Ginkgo biloba (Gingko biloba L) is a plant of the genus Ginkgoaceae (Ginkgoaceae), also known as ginkgo tree and Gongsun tree. It is a relict plant of the Permian in the Paleozoic Era. It is called the "living fossil" of gymnosperms and is widely distributed in my country. Since the 1960s, domestic and foreign scholars have done a lot of research on its chemical composition, pharmacological effects and clinical application. Pharmacological studies have shown that Ginkgo biloba extract can expand coronary blood vessels, increase cerebral blood flow, improve brain nutrition, and has obvious anti-platelet activating factor and antibacterial effects, especially the unique effect of Ginkgo biloba extract on the nervou...

Claims

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Application Information

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IPC IPC(8): A61K36/16A61K127/00
Inventor 陈洪章付小果
Owner INST OF PROCESS ENG CHINESE ACAD OF SCI
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