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A detection method for Ruhe Sanjie capsules

A detection method and capsule technology, which can be used in capsule delivery, measuring devices, pharmaceutical formulations, etc., and can solve problems such as unfavorable product quality control

Active Publication Date: 2011-12-14
刘坤
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing detection methods for Ruhe Sanjie Tablets only include the identification of Angelica, Astragalus and Epimedium, while other active ingredients have a large proportion in the composition ratio of Ruhe Sanjie Capsules, and in Ruhe Sanjie Capsules It plays an important role in the treatment of related diseases. Failure to detect these active ingredients in the production process is not conducive to the quality control of the product. Therefore, it is necessary to further improve the detection method of Ruhe Sanjie Capsules

Method used

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  • A detection method for Ruhe Sanjie capsules
  • A detection method for Ruhe Sanjie capsules
  • A detection method for Ruhe Sanjie capsules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0109] Instruments and reagents:

[0110] Ruhe Sanjie Capsule: produced by Shaanxi Jiali Pharmaceutical Co., Ltd., batch number: 100701;

[0111] Reagent:

[0112]

[0113]

[0114] instrument:

[0115] serial number

equipment name

Specification

place of origin

purpose

1

UV light

365nm

beijing optical instrument factory

Detection of Fluorescent Spots of Angelica Essential Oil

2

centrifuge

3500 rpm

Shanghai Precision Instrument Factory

separation solution

3

Water bath constant temperature pot

four holes

beijing optical instrument factory

for evaporation

4

Heating mantle

500

Shanxi Juancheng Instrument Factory

heat reflux

5

ultrasound

Shanghai Precision Instrument Factory

ultrasonic extraction

6

Electric thermostat

Beijing Kewei Instrument Factory

drying

7

High performance liquid chromato...

Embodiment 2

[0125]

[0126]

[0127] For the above ten flavors, extract the volatile oil from angelica for later use. After the oil is extracted, the dregs of angelica and the remaining nine flavors such as astragalus are decocted once for 3 hours each time, filtered, and the filtrates are combined and concentrated to a thick paste with a relative density of 1.30-1.35. , add 20 parts by weight of calcium hydrogen phosphate, mix evenly, dry under reduced pressure, pulverize, spray into angelica oil diluted with ethanol, mix evenly, make tablet according to conventional method.

[0128] Identification:

[0129] 1 Take 10g of the contents of the capsule, grind it finely, put it in an Erlenmeyer flask, add 50ml of petroleum ether at 60-90°C, ultrasonically treat it for 20 minutes, filter, and use the filter residue for later use; the filtrate is evaporated to about 0.5ml, and used as the test solution; Take another 1 g of Angelica as reference drug, add 15 ml of petroleum ether at 60-90...

Embodiment 3

[0136]

[0137] For the above ten flavors, extract the volatile oil from angelica for later use. After the oil is extracted, the dregs of angelica and the remaining nine flavors such as astragalus are decocted with water for 3 times, each time for 1 hour, filtered, combined with the filtrate, and concentrated to a thick paste with a relative density of 1.30-1.35. , add 40 parts by weight of calcium hydrogen phosphate, mix well, dry under reduced pressure, pulverize, spray into angelica oil diluted with ethanol, mix well, make tablet by conventional method.

[0138] Identification:

[0139] 1 Take 10g of the contents of the capsule, grind it finely, put it in an Erlenmeyer flask, add 50ml of petroleum ether at 60-90°C, ultrasonically treat it for 20 minutes, filter, and use the filter residue for later use; the filtrate is evaporated to about 0.5ml, and used as the test solution; Take another 1 g of Angelica as reference drug, add 15 ml of petroleum ether at 60-90 ° C, ultra...

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Abstract

The invention provides a method for detecting Chinese medicinal capsules for treating breast disease, such as capsules for treating nodule in breast by dissolving stasis. The detection method comprises: 1, detecting active ingredients from Chinese angelica by thin-layer chromatography; 2, detecting astragaloside IV and icariin by thin-layer chromatography; 3, detecting saikoside alpha by thin-layer chromatography; and / or 4 detecting active ingredients from Chinese pyrola herb by thin-layer chromatography. The detection method can accurately and completely reflect the content of medicinal components of the capsules for treating nodule in breast by dissolving stasis and therefore can provide a guarantee for the industrial production and clinic use of the capsules for treating nodule in breast by dissolving stasis.

Description

technical field [0001] The invention relates to a detection method of traditional Chinese medicine preparations for treating breast diseases, in particular to a detection method of Ruhe Sanjie capsules. Background technique [0002] Mammary gland hyperplasia belongs to the category of "breast addiction", "breast swelling" and "breast tuberculosis" in traditional Chinese medicine. It is a common disease and frequently-occurring disease in young and middle-aged women. The relative increase of estrogen, or the relative decrease of progesterone caused by the deficiency of estrogen, thus leads to long-term stimulation of target organs such as breast by estrogen, resulting in repeated attacks of interstitial edema in breast glandular tissue, forming glandular hyperplasia-like changes. According to the report of the National Population Association in 2010, the incidence rate is about 52.40%. If not treated early, about 2% to 4% of patients may have cystic hyperplasia and cause canc...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61K9/48G01N30/90A61P15/14
Inventor 刘坤
Owner 刘坤
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