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The method for extracting chrysin from the passion fruit residue after squeezing the juice

A technology of passionflower and chrysin, applied in the direction of organic chemistry, etc., to achieve the effects of short production cycle, reduced production cost, and simple and easy-to-control process

Inactive Publication Date: 2011-12-21
GUILIN SANBAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, passion fruit fruit is mainly used to make fruit juice drinks, and its main use part is pulp and juice in the fruit, and seeds and peels are also used to extract pectin and oil as raw materials for the food industry. The residue (including the peel and seeds, and part of the pulp juice) is mostly discarded as waste

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] 1) crush the Passiflora fruit residue after squeezing the juice, and cross No. 1 Pharmacopoeia sieve for subsequent use; Take 50kg and place it in an extraction tank, add 65% (v / v) ethanol of 8 times the weight of raw materials, and use 10% (w / w) Sodium hydroxide solution adjusts pH=9.0, heats and carries out the first reflux extraction, extraction time is 2h, filters, and filter residue adds 65% (v / v) ethanol of 8 times raw material weight again, with 10% (w / w) adjust pH=9.0 with sodium hydroxide solution, perform reflux extraction for the second time, the extraction time is 2h, and combine the extracts;

[0020] 2) The extract is cooled in an alcohol sink, then suction filtered after cooling, the filtrate is adjusted to pH = 2.8 with dilute hydrochloric acid, stirred thoroughly and left to stand for 4 hours, so that chrysin will be precipitated from the solution system, suction filtered, and the filter cake is used first Wash with pure water at pH=5.5, then wash wit...

Embodiment 2

[0024] 1) Pulverize the passion fruit residue after squeezing the juice, and cross No. 1 Pharmacopoeia sieve for subsequent use; Take 80kg and place it in an extraction tank, add 65% (v / v) methanol of 10 times the weight of raw materials, and use 10% (w / w) adjust pH=10.2 with sodium carbonate solution, heat to carry out reflux extraction, the extraction time is 2h, filter, and collect the extract;

[0025] 2) Cool the extract in an alcohol sink, then suction filter after cooling, adjust the pH of the filtrate to 1.2 with dilute hydrochloric acid, let it stand for 8 hours after fully stirring, so that chrysin will precipitate from the solution system, suction filter, and wash the filter cake with water To pH=7, suction filtration, the resulting filter cake is crude chrysin;

[0026] 3) Dissolving the crude chrysin in ethyl acetate equivalent to 10 times its weight (heating to 40°C for dissolution), filtering, and concentrating the filtrate to an extract;

[0027] 4) Add 50% (...

Embodiment 3

[0029] 1) the passion fruit residue after squeezing the juice is pulverized, and crosses the No. 1 Pharmacopoeia sieve for subsequent use; Take 60kg by weighing and place in the extraction tank, add 90% (v / v) ethanol of 6 times of raw material weight, use 10% (w / w) Potassium hydroxide solution to adjust pH=9.6, heating for the first reflux extraction, extraction time is 1h, filtering, adding 90% (v / v) ethanol of 5 times the weight of raw materials to the filter residue, and using 10% (w / w) Potassium hydroxide solution is adjusted to pH=9.6, and the second reflux extraction is carried out, and the extraction time is 2h, and 70% (v / v) ethanol of 4 times the weight of raw materials is added to the filter residue after filtration, and 10% (w / w) ) Potassium hydroxide solution to adjust the pH=9.6, perform the third reflux extraction, the extraction time is 1h, and combine the extracts;

[0030] 2) The extract is cooled in an alcohol sink, then filtered with suction after cooling,...

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PUM

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Abstract

The invention discloses a method for extracting chrysin from passiflora edulis fruit residue obtained after juicing, which comprises: adding chrysin from passiflora edulis fruit residue obtained after juicing into low-carbon alcohol, regulating the pH value of the obtained mixed solution to 9 to 12 by using alkaline solution, and performing refluxing extraction for 1 to 3 times, 1 to 2 hours eachtime; combining extracting solution, cooling and pumping under vacuum; regulating the pH value of the filtrate to 1 to 3 by using an acid; standing, precipitating, and filtering under vacuum; dissolving a filter cake in ethyl acetate, filtering, and concentrating filtrate to obtain extract; adding low-carbon alcohol into the extract and regulating the pH value to 9 to 12 by using alkaline solution, heating, dissolving and cooling; regulating the pH value to 5 to 7 by using an acid, standing, precipitating, and filtering under vacuum; and washing an obtained filter cake, dying and thus obtaining chrysin. In the method disclosed by the invention, the juiced passiflora edulis fruit residue treated as a waste is used as a raw material for extraction, so the waste is recycled and resources aresaved effectively; and the production method disclosed by the invention is low in production cost, makes a process simple and easy to control, requires short production period and is suitable for industrial production.

Description

technical field [0001] The invention relates to a method for extracting active components in plants, in particular to a method for extracting chrysin from juice-pressed passion fruit residue. Background technique [0002] Chrysin (CR) is 5,7-dihydroxyflavone, also known as chrysin, molecular formula C 15 h 10 o 4 , the relative molecular weight is 254, pale yellow prismatic crystal (methanol), easily soluble in sodium hydroxide solution, slightly soluble in ether, ethanol and chloroform, insoluble in water. Chrysin is a flavonoid commonly found in nature. It has anti-oxidation, anti-hypertension, anti-diabetes, anti-virus and anti-tumor effects. It mainly exists in Oroxylum indicum (L.) Vent. ), the heartwood of Pinus mon-ticola Dougl., the heartwood of Pinus mon-ticola Dougl., etc.; in addition, it also exists in many other plants such as passionflower. [0003] Passionflower (Passionfora edulis f.flavicarpa Deg) is a perennial vine climbing plant of the Passiflora fami...

Claims

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Application Information

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IPC IPC(8): C07D311/30C07D311/40
Inventor 卢昶年卢照凯谢冬养钟德品周晓青谢丹陆美珍
Owner GUILIN SANBAO PHARMA
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