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Philippine flemingia kidney meprobamate pharmaceutical composition, production method thereof, and preparation thereof

A composition and drug technology, applied in the directions of drug combination, pharmaceutical formula, plant raw materials, etc., can solve the problems of easy interference of active ingredients by other medicinal materials, low utilization rate of medicinal materials, insufficient extraction, etc. Accurate clinical effect and high extraction rate

Active Publication Date: 2012-01-04
GUIZHOU YIBAI PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In the above preparation methods, the monarch drug Qianjinba adopts the method of water extraction and alcohol precipitation together with other medicinal materials, and the extraction of active ingredients is easily interfered by other medicinal materials, resulting in a low extraction rate; The extraction is also insufficient, and the utilization rate of medicinal materials is low
In addition, other medicinal materials except Qianjinba, Epimedium, Cordyceps, Psoraleae, Red Ginseng, and Panax notoginseng, only use water extraction and alcohol precipitation in the existing production method, which is very easy to introduce impurities

Method used

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  • Philippine flemingia kidney meprobamate pharmaceutical composition, production method thereof, and preparation thereof
  • Philippine flemingia kidney meprobamate pharmaceutical composition, production method thereof, and preparation thereof
  • Philippine flemingia kidney meprobamate pharmaceutical composition, production method thereof, and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0081] Embodiment 1: the preparation of capsule

[0082] 556 grams of Qianjinba, 167 grams of Epimedium, 167 grams of psoralen, 84 grams of Cordyceps sinensis, 167 grams of red ginseng, 167 grams of sealwort, 167 grams of Polygonum multiflorum, 167 grams of Rehmannia glutinosa, 222 grams of coix seed, 222 grams of Guangyam, Gorgon fruit 222 grams, 278 grams of Yingbupu, 84 grams of Panax notoginseng, 84 grams of rhubarb

[0083] The preparation process is:

[0084] (1) Cordyceps sinensis, red ginseng, Radix Notoginseng are crushed, passed through 80 mesh sieves, and weighed;

[0085] (2) Sliced, add 8 times the amount of water and boil 3 times, each extraction time is 3 hours, combine the decoction, concentrate, add 75% ethanol to make the alcohol content 50%, let it stand for 48 hours, precipitate, combine , reclaiming ethanol, reclaiming ethanol under reduced pressure, and obtaining the extract of jackfruit;

[0086](3) Epimedium and psoraleae are heated and refluxed with...

Embodiment 2

[0090] Embodiment 2: the preparation of tablet

[0091] Qianjinba 278g, Epimedium 83.5g, Psoralen 83.5g, Cordyceps sinensis 42g, Red Ginseng 83.5g, Polygonatum 83.5g, Radix Polygoni Multiflori 83.5g, Rehmannia glutinosa 83.5g, Coix seed 111g, Guangyam 111g, Gorgon fruit 111 grams, 139 grams of Yingbupu, 42 grams of Panax notoginseng, 42 grams of rhubarb

[0092] (1) Cordyceps sinensis, red ginseng, Radix Notoginseng are crushed, passed through a 60-mesh sieve, and weighed;

[0093] (2) Sliced ​​into pieces, add 5 times the amount of water to boil twice, each extraction time is 2 hours, combine the decoction, concentrate, add 60% ethanol to make the alcohol content 50%, let it stand for 24 hours, precipitate, and combine , reclaiming ethanol, reclaiming ethanol under reduced pressure, and obtaining the extract of jackfruit;

[0094] (3) Epimedium and psoraleae are heated and refluxed with 50% ethanol for 4 times, and the amount of ethanol used for the second and subsequent ti...

Embodiment 3

[0098] Embodiment 3: the preparation of granule

[0099] Qianjinba 1112g, Epimedium 334g, Psoralen 334g, Cordyceps sinensis 168g, Red Ginseng 334g, Polygonatum 334g, Radix Polygoni Multiflori 334g, Rehmannia glutinosa 334g, Coix seed 444g, Guangyam 444g, Gorgon fruit 444 grams, 556 grams of Yingbupu, 168 grams of Panax notoginseng, 168 grams of rhubarb

[0100] The preparation method is:

[0101] (1) Cordyceps sinensis, red ginseng, Radix Notoginseng are crushed, passed through a 100-mesh sieve, and weighed;

[0102] (2) Sliced, add 10 times the amount of water to boil 4 times, each extraction time is 4 hours, combine the decoction, concentrate, add 75% ethanol to make the alcohol content 60%, let stand for 60 hours, make precipitation, combine , reclaiming ethanol, reclaiming ethanol under reduced pressure, and obtaining the extract of jackfruit;

[0103] (3) Epimedium and psoralen are heated and refluxed with 75% ethanol for 4 times, and the amount of ethanol used for the...

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Abstract

The invention discloses a philippine flemingia kidney meprobamate pharmaceutical composition, a production method thereof, and a preparation thereof. The pharmaceutical composition is composed of traditional Chinese medicines of philippine flemingia root, red ginseng, panax notoginseng, epimedium, psoralea corylifolia, Chinese caterpillar fungus, siberian solomonseal rhizome, prepared fleeceflower root, rehmannia, ma-yuen jobstears seed, Guangdong common yam rhizome, gordon euryale seed, spine aralia root, rhubarb, and the like. According to the invention, the principal medicine philippine flemingia root is separately extracted, such that a medicine material extraction rate is high, the cost is saved, and the potency is improved; epimedium, psoralea corylifolia and ethanol are heated and refluxed, an extract is processed through a macroporous resin column, such that effective components in the medicines are further separated, impurities such as tannin and protein in the medicines are removed, the loss rate of an effective component alkaloid in the medicines is reduced, such that the medicines are more sufficiently purified and refined; water extraction and alcohol precipitation is carried out upon 8 medicine materials such as siberian solomonseal rhizome, the materials are discolored by using active carbon, and the medicines are condensed and filtered, such that impurities in the medicines are effectively removed. With the preparation method provided by the invention, the philippine flemingia kidney meprobamate pharmaceutical composition preparation is refined, the bioavailability is improved, and the potency is more substantial. The method and the preparation are suitable for industrialized productions.

Description

technical field [0001] The invention relates to a Qianjin Shenanning pharmaceutical composition, a preparation method and a preparation thereof, and belongs to the field of traditional Chinese medicines. Background technique [0002] Chronic nephritis is a group of immune inflammatory diseases that originate in the glomerulus caused by various reasons. Its main clinical features are: edema, proteinuria, hematuria or hypertension. Most patients have different degrees of renal dysfunction, and many patients eventually induce renal insufficiency. According to its clinical manifestations, it belongs to the categories of "edema", "low back pain", "asthenia", "hematuria" and other syndromes in traditional Chinese medicine. Therefore, in principle, the corresponding pathogenesis and treatment can be sought from the above syndrome categories. The pathogenesis of this disease, currently most scholars believe that the location of the disease is in the kidney, which is related to the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8994A61P13/12
Inventor 窦啟玲熊仕芳陈珊韦健容菊艳
Owner GUIZHOU YIBAI PHARMA CO LTD