Method for preparing diclazuril microemulsion
A technology of diclazuril and microemulsion, which is applied in the fields of emulsion delivery, anti-infective drugs, and active ingredients of heterocyclic compounds, etc. It can solve the problems of strong toxic and side effects, short duration of drug effect, poor stability of diclazuril solution, etc. problems, to achieve the effect of high drug loading, obvious targeting, and reduced drug dosage
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Embodiment 1
[0044] (1) Formulation:
[0045] Diclazuril 0.1g, tea oil 4ml, Tween-605ml, propylene glycol 2ml, vitamin E0.3ml, methyl p-hydroxybenzoate 0.1g, sodium carboxymethyl cellulose 0.2g, dimethyl sulfoxide 3ml, ethanolamine 0.5 ml, ethanol 2ml, and purified water to 100ml.
[0046] (2) Preparation process:
[0047] ①Take dimethyl sulfoxide, heat to 50°C, add diclazuril, stir evenly, add ethanolamine, stir to dissolve completely, set aside;
[0048] ②Take vitamin E and Tween-60, add them to camellia oil respectively, stir evenly, make oil phase, set aside;
[0049] ③Add sodium carboxymethylcellulose into purified water, control the water temperature at 80-90°C, stir to make it dissolve evenly, then add propylene glycol, stir evenly, and make a water phase for later use;
[0050] ④ First add the liquid described in ② into the colloid mill, grind for 5 minutes at a speed of 5000 rpm, then put the liquid described in ③ into it, mix and grind for 5 minutes, then add the liquid descri...
Embodiment 2
[0054] (1) Formulation:
[0055] Diclazuril 0.5g, soybean oil 6ml, Tween-808ml, glycerol 5ml, vitamin E0.4ml, ethyl p-hydroxybenzoate 0.1g, sodium carboxymethylcellulose 0.4g, dimethyl sulfoxide 4ml, Add 0.6ml of triethanolamine, 2ml of ethanol, and purified water to 100ml.
[0056] (2) Preparation process:
[0057] ①Take dimethyl sulfoxide, heat to 50°C, add diclazuril, stir evenly, add triethanolamine, stir to dissolve completely, set aside;
[0058] ②Take vitamin E and Tween-80, add them to soybean oil respectively, stir evenly, make oil phase, set aside;
[0059] ③Add sodium carboxymethyl cellulose to purified water, control the water temperature at 80-90°C, stir to dissolve evenly, then add glycerin, stir evenly, and make a water phase for later use;
[0060] ④ First add the liquid described in ② into the colloid mill, grind for 5 minutes at a speed of 5000 rpm, then put the liquid described in ③ into it, mix and grind for 5 minutes, then add the liquid described in ① ...
Embodiment 3
[0064] (1) Formulation:
[0065] Diclazuril 0.6g, cottonseed oil 6ml, Tween-608ml, glycerol 5ml, vitamin E0.4ml, methyl p-hydroxybenzoate 0.2g, sodium carboxymethylcellulose 0.4g, dimethyl sulfoxide 4ml, Add 0.6ml of ethanolamine, 2ml of ethanol, and purified water to 100ml.
[0066] (2) Preparation process:
[0067] ①Take dimethyl sulfoxide, heat to 50°C, add diclazuril, stir evenly, add ethanolamine, stir to dissolve completely, set aside;
[0068] ②Take vitamin E and Tween-60, add them to cottonseed oil respectively, stir evenly, make oil phase, and set aside;
[0069] ③Add sodium carboxymethyl cellulose to purified water, control the water temperature at 80-90°C, stir to dissolve evenly, then add glycerin, stir evenly, and make a water phase for later use;
[0070] ④ First add the liquid described in ② into the colloid mill, grind for 5 minutes at a speed of 5000 rpm, then put the liquid described in ③ into it, mix and grind for 5 minutes, then add the liquid described ...
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