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MS/MS mass spectrometer

A technology of mass spectrometry and mass separation, applied in the field of MS/MS mass spectrometry devices, to achieve the effects of reducing time delay, improving detection sensitivity, and improving accuracy

Active Publication Date: 2012-01-04
SHIMADZU SEISAKUSHO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, even if such a collision cell is used, it takes several msec for the ions to pass through the collision cell, so sensitivity degradation and mass shift cannot be avoided at a mass scanning speed of about 1000 [u / sec].

Method used

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Examples

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no. 1 Embodiment

[0068] Hereinafter, a triple quadrupole mass spectrometer as an embodiment (first embodiment) of the present invention will be described with reference to the drawings. figure 1 is a schematic configuration diagram of the triple quadrupole mass spectrometer of the first embodiment, figure 2 It is a schematic diagram for explaining the characteristic operation of the triple quadrupole mass spectrometer of this embodiment.

[0069] In the triple quadrupole mass spectrometry device of this embodiment, as in the past, the quadrupole of the first stage (corresponding to the first mass separation part of the present invention) 13 and the quadrupole of the third stage (corresponding to the first mass separation part of the present invention) Between the inventive second mass separation unit) 17, a collision cell 14 for splitting precursor ions and generating various product ions is disposed.

[0070] A voltage ±(U1+V1·cosωt) that synthesizes a DC voltage U1 and a high-frequency vo...

no. 2 Embodiment

[0082] Next, pass image 3 as well as Figure 4 A triple quadrupole mass spectrometer as another embodiment (second embodiment) of the present invention will be described. image 3 is a schematic configuration diagram of a triple quadrupole mass spectrometer in the second embodiment, Figure 4 It is a schematic diagram for explaining the characteristic operation of the triple quadrupole mass spectrometer of this embodiment. exist image 3 In , the same symbols are assigned to the same components as those of the triple quadrupole mass spectrometer of the first embodiment already described. In the triple quadrupole mass spectrometer of the second embodiment, a mass scan correction data storage unit 28 storing predetermined correction data in advance is connected to the control unit 24 .

[0083] As described above, when the CID gas is introduced into the collision cell 14 for ion fragmentation, the time delay of the ions passing there is long. Here, in the mass spectrometry...

no. 3 Embodiment

[0086] Next, pass Figure 5 A triple quadrupole mass spectrometer as still another embodiment (third embodiment) of the present invention will be described. Figure 5 It is a schematic diagram for explaining the characteristic operation of the triple quadrupole mass spectrometer of the third embodiment. Since the basic configuration of this triple quadrupole mass spectrometer is the same as that of the second embodiment, description thereof will be omitted.

[0087] In the triple quadrupole mass spectrometer of the second embodiment, the delay time t at the start of the mass scan of the third-stage quadrupole 17 under various splitting conditions is stored as correction data in the mass scan In the correction data storage unit 28 , however, in the triple quadrupole mass spectrometer of the third embodiment, data for correcting the mass-to-charge ratio difference of the mass scan is stored in the mass scan correction data storage unit 28 . That is, when there is a time delay ...

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Abstract

A CID gas is introduced into a collision cell (14). An application voltage is set so that mass separation is not substantially effected by a third-stage quadrupole (17). While mass scanning in a predetermined range is effected by a first-stage quadrupole (13), mass spectrometry of a reference sample whose mass / charge ratio is known is effected. Various species of product ions originated from precursor ions selected by the first-stage quadrupole (13) are not separated, reach a detector (18), and are detected. Therefore, a data processing unit (25) acquires the relation between the voltage applied to the first-stage quadrupole (13) and the determined mass / charge ratio of the ions on the basis of the detected data. The relation reflects the time delay at the collision cell and is stored in a calibration data storage unit (26). By using the relation for neutral loss scanning measurement, the mass variation due to the time delay at the collision cell (14) is solved, and product ions over the whole mass range can be detected with high sensitivity. A mass spectrum having a high-accuracy mass axis can be created.

Description

technical field [0001] The present invention relates to an MS / MS type mass spectrometry device that splits ions having a specific mass-to-charge ratio (m / z) by collision-induced dissociation (CID=Collision-Induced Dissociation) , mass analysis of the product ions (fragment ions) thus generated is performed. Background technique [0002] A method called MS / MS analysis (also called tandem analysis) is known as one method of mass spectrometry in order to identify a substance with a large molecular weight and analyze its structure. As a typical MS / MS type mass spectrometer, there is a triple quadrupole (TQ) type mass spectrometer. Figure 6 It is a schematic configuration diagram of a general triple quadrupole mass spectrometer disclosed in Patent Documents 1, 2, and the like. [0003] In this mass spectrometer, the analysis chamber 11 is evacuated by a vacuum pump (not shown), and inside the analysis chamber 11, an ion source 12 for ionizing a sample to be analyzed is provided...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): H01J49/42G01N27/62
CPCH01J49/0045H01J49/0009H01J49/0027
Inventor 奥村大辅
Owner SHIMADZU SEISAKUSHO LTD
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